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615 results for “central nervous system”
Spatial Atlas of the Mouse Central Nervous System at Molecular Resolution
<p>Spatially charting molecular cell types at single-cell resolution across the three-dimensional (3D) volume of the brain is critical for illustrating the molecular basis of the brain anatomy and functions. Single-cell RNA sequencing (scRNA-seq) has profiled molecular cell types in the mouse brain, but cannot capture their spatial organization. Here, we employed an in situ sequencing technique, STARmap PLUS, to map 1.09 million high-quality cells across the whole adult mouse brain and the spinal cord, profiling 1,022 genes at subcellular resolution with a voxel size of 194 X 194 X 345 nm3 in 3D. We developed computational pipelines to segment, cluster, and annotate 230 molecular cell types by single-cell gene expression and 106 molecular tissue regions by spatial niche gene expression. Joint analyses of molecular cell types and molecular tissue regions enabled a systematic molecular spatial cell type nomenclature and allowed the identification of tissue architectures previously undefined in established brain anatomy. To create a transcriptome-wide spatial atlas, we further integrated the STARmap PLUS measurements with a published scRNA-seq atlas, imputing 11,844 genes at the single-cell level. Finally, we delineated the tropisms of a brain-wide transgene delivery tool, AAV-PHP.eB5,6, across the molecular cell types and tissue regions of the whole mouse brain. Together, this annotated dataset provides a comprehensive, high-resolution, single-cell resource that integrates a spatial molecular atlas, cell taxonomy, brain anatomy, and genetic manipulation accessibility of the mammalian central nervous system (CNS).</p>
Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma
ClinicalTrials.gov study NCT00000801. IPD Sharing: Not stated. Countries: 1. Publications: 1.
High-dose Chemotherapy and Stem Cell Transplantation for Central Nervous System (CNS) Relapse of Aggressive Lymphomas
ClinicalTrials.gov study NCT01148173. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Characterization of Human Autoantibody Titers After Central Nervous System Insult
ClinicalTrials.gov study NCT03089749. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Adjunctive Doxycycline for Central Nervous System Tuberculosis
ClinicalTrials.gov study NCT06446245. IPD Sharing: UNDECIDED. Countries: 3. Publications: 3.
A Study of Soticlestat in Healthy Adult Nondependent Recreational Drug Users With Central Nervous System (CNS) Depressant Experience
ClinicalTrials.gov study NCT05602818. IPD Sharing: YES. Countries: 1. Publications: 0.
Nivolumab and Ibrutinib in Treating Patients With Relapsed or Refractory Central Nervous System Lymphoma
ClinicalTrials.gov study NCT03770416. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ibrutinib With Rituximab and Lenalidomide for Patients With Recurrent/Refractory Primary or Secondary Central Nervous System Lymphoma (PCNSL/SCNSL)
ClinicalTrials.gov study NCT03703167. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Methotrexate-based Chemo-immunotherapy Followed by Maintenance Therapy for Patients > 65 Years With Central Nervous System (CNS)-Lymphoma
ClinicalTrials.gov study NCT00989352. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Exercise Therapy in Combination With Central Nervous System-targeted Treatment for Osteoarthritis
ClinicalTrials.gov study NCT03681613. IPD Sharing: Not stated. Countries: 1. Publications: 36.
First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases
ClinicalTrials.gov study NCT03653546. IPD Sharing: NO. Countries: 4. Publications: 1.
Orelabrutinib,Rituximab and Methotrexate in Newly Diagnosed Primary Central Nervous System Lymphoma
ClinicalTrials.gov study NCT05600660. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous System
ClinicalTrials.gov study NCT06467773. IPD Sharing: NO. Countries: 1. Publications: 5.
Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)
ClinicalTrials.gov study NCT07104032. IPD Sharing: NO. Countries: 1. Publications: 0.
Intraoperative Brachytherapy for Central Nervous System Lesions: A Validation Study of a Radioactive Seed Loading Device
ClinicalTrials.gov study NCT03088579. IPD Sharing: NO. Countries: 1. Publications: 1.
Chemotherapy and Whole-Brain Radiation Therapy in Treating Patients With Primary Central Nervous System Non- Hodgkin's Lymphoma
ClinicalTrials.gov study NCT00002676. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intermittent High-Dose Lapatinib in Tandem With Capecitabine for HER2 Overexpressed/Amplified Metastatic Breast Cancer With Central Nervous System (CNS) Metastases
ClinicalTrials.gov study NCT02650752. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Apatinib in Recurrent or Refractory Intracranial Central Nervous System Malignant Tumors
ClinicalTrials.gov study NCT03660761. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy of Lenalidomide With Rituximab in Refractory or Relapse of Primary Central Nervous System Lymphoma
ClinicalTrials.gov study NCT01956695. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Inflammatory Process and the Medical Imaging in Patients With an Inflammatory Disease of the Central Nervous System.
ClinicalTrials.gov study NCT01567553. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.