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136
datasets available to search
ShareScore release 0.9.0
Dataset results
136 results for “diet modelling”
Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension
GEO Series GSE269053. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production
GEO Series GSE223582. Rattus norvegicus. 10 samples. Type: Expression profiling by high throughput sequencing.
Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH
GEO Series GSE196908. Mus musculus. 97 samples. Type: Expression profiling by high throughput sequencing.
Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model
GEO Series GSE119141. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Effect of obesity on liver immune response to inflammatory stimuli in a diet-obesity model of zebrafish (Danio rerio)
GEO Series GSE56478. Danio rerio. 16 samples. Type: Expression profiling by array.
Introducing a new pre-clinical rat model of advanced NASH by combining carbon tetrachloride with high fat & cholesterol diet
GEO Series GSE129525. Rattus norvegicus. 18 samples. Type: Expression profiling by high throughput sequencing.
Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity
GEO Series GSE155197. Sus scrofa. 29 samples. Type: Methylation profiling by high throughput sequencing.
A high-fat plus high-sucrose diet induces age-related macular degeneration in an experimental rabbit model
GEO Series GSE276438. Oryctolagus cuniculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Hyperandrogenemia and western-style diet act synergistically on transcription and DNA methylation in visceral adipose tissue of a non-human primate model [RNA-Seq]
GEO Series GSE124707. Macaca mulatta. 24 samples. Type: Expression profiling by high throughput sequencing.
Data from: Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome
The human gut microbiota is an important metabolic organ. However, little is known about how its individual species interact, establish dominant positions, and respond to changes in environmental factors such as diet. In the current study, gnotobiotic mice colonized with a simplified model microbiota composed of 12 sequenced human gut bacterial species were fed oscillating diets of disparate composition. Rapid, reproducible and reversible changes in community structure were observed. Time series microbial RNA-Seq analyses revealed staggered functional responses to diet shifts throughout the community that were heavily focused on carbohydrate and amino acid metabolism. High-resolution shotgun metaproteomics confirmed many of these responses at a protein level. One member, Bacteroides cellulosilyticus WH2, proved exceptionally fit regardless of diet. Its genome encoded more carbohydrate active enzymes than any known Bacteroidetes. Transcriptional profiling indicated that B. cellulosilyticus WH2 is an adaptive forager that tailors its versatile carbohydrate utilization strategy to available dietary polysaccharides, with a strong emphasis on plant-derived xylans abundant in dietary staples like cereal grains. Two highly expressed, diet-specific polysaccharide utilization loci (PULs) in B. cellulosilyticus WH2 were identified, one with characteristics of xylan utilization systems. Introduction of a B. cellulosilyticus WH2 library comprising 26,750 isogenic transposon mutants into gnotobiotic mice along with other model community members confirmed that these loci represent critical diet-specific fitness determinants. The specific carbohydrates that trigger overexpression of these two loci and many of the organism's 111 other predicted PULs were identified by RNA-Seq during in vitro growth on 31 distinct carbohydrate substrates, allowing us to better interpret in vivo RNA-Seq and proteomics data. These results offer insight into how gut microbes adapt to dietary perturbations, both at a community level and from the perspective of a well-adapted symbiont with exceptional saccharolytic capabilities, and illustrate the value of studying defined models of the human gut microbiota.
Exploring the Effects of Varying Fat:Carbohydrate Diet Permutations on Gastric Emptying and Metabolic Status Using Human Postprandial Model
ClinicalTrials.gov study NCT05977244. IPD Sharing: NO. Countries: 1. Publications: 0.
Energy and Nutrient Profiles When Asians Transit From a Meat-based to a Plant-based Diet: A Modelling Exercise
ClinicalTrials.gov study NCT05635825. IPD Sharing: NO. Countries: 1. Publications: 0.
Capability Assessment for Diet and Activity (CADA) Model for Diabetes
ClinicalTrials.gov study NCT06631105. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A NEW PRECLINICAL MODEL OF WESTERN DIET-INDUCED PROGRESSION OF NON-ALCOHOLIC STEATOHEPATITIS TO HEPATOCELLULAR CARCINOMA
GEO Series GSE197884. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dietary amino acid source elicits sex-specific metabolic response to diet-induced NAFLD in murine model.
GEO Series GSE234591. Mus musculus. 64 samples. Type: Expression profiling by array.
Data from: Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome
Open the record for dataset details and reuse information.
Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson's disease
GEO Series GSE210005. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of linoleic acid metabolite on liver gene expression in a diet-induced NAFLD/NASH model.
GEO Series GSE242881. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of Diet on Resource Utilization by a Model Human Gut Microbiota Containing Bacteroides cellulosilyticus WH2, a Symbiont with an Extensive Glycobiome (COPRO-Seq)
GEO Series GSE48193. Bacteria. 611 samples. Type: Expression profiling by high throughput sequencing; Other.
High-fat diet promotion of endometriosis in an immunocompetent mouse model is associated with altered peripheral and ectopic lesion redox and inflammatory status
GEO Series GSE80603. Mus musculus. 4 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.