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335 results for “disease resistance”
Contrasting disease progression, microglia reactivity, tolerance, and resistance to Toxoplasma gondii infection in two mouse strains
<p><strong><span>Figure S1</span></strong><span>. Stereological Sampling: Low-power photomicrographs (A and B) displaying the molecular layer of the dentate gyrus, the area of interest, alongside the sampling grid (C). Additionally, a high-power photomicrograph (D) showcases IBA-1 immunolabeled microglia (the object of interest). Scale bar: A - 250µm, and D: 25µm.</span></p> <p> </p> <p><strong><span>Figure S2</span></strong><span>. The recovery of BALB/c microglia in the molecular layer of dentate gyrus was observed 43 days after infection. At this point, only minor morphological changes were observed, and all the morphological changes induced by <em>T. gondii</em> infection at 22 dpi have disappeared. The analysis methods used included hierarchical cluster analysis (A), discriminant function analysis (C and E), morphological complexity (B), and convex hull volume (D).</span></p>
Dataset of Indication of Quantitative Multiple Disease Resistance to Foliar Pathogens in Pinus radiata D.Don in New Zealand
<p>The file contains the phenotypic data and pedigree information used to produce the manuscript <strong>Indication of quantitative cross-resistance to foliar pathogens in </strong><strong><em>Pinus radiata </em></strong><strong>D.Don</strong></p>
A fungal endophyte induces local cell-wall mediated resistance in wheat roots against take-all disease
<p>Datasets to accompany 'A fungal endophyte induces local cell-wall mediated resistance in wheat roots against take-all disease', <span>DOI: 10.3389/fpls.2024.1444271.</span></p> <p><span>These are datasheet 1 and table S2.</span></p> <p> </p>
Global Transcriptomic Analysis of Topical Sodium Alginate Protection Against Peptic Damage in An In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease
<p>PA= pepsin + Acid; "Sham + PA" means "Pretreatment + Treatment"</p> <p><span>Breakthrough symptoms </span>are thought to occur in roughly half of <span>all </span>gastroesophageal reflux disease (GERD) patients despite maximal acid suppression (proton pump inhibitor, PPI) therapy. Topical alginates have recently been shown to enhance mucosal defense against acid-pepsin insult during GERD. We aimed to examine potential alginate protection of transcriptomic changes in a cell culture model of PPI recalcitrant GERD. Immortalized normal-derived human esophageal epithelial cells underwent pretreatment with commercial alginate-based anti-reflux medications (Gaviscon Advance or Gaviscon Double Action), a matched-viscosity placebo control, or pH 7.4 buffer (sham) alone for 1 minute, followed by exposure to pH 6.0+pepsin or buffer alone for 3 minutes. RNA sequencing was conducted, and Ingenuity Pathway Analysis was performed with a false discovery rate of ≤0.01, and absolute fold-change of ≥<span>1.3. Pepsin-acid exposure disrupted gene expressions associated with epithelial barrier function, chromatin structure</span>, carcinogenesis, and inflammation<span>. Alginate formulations demonstrated protection by mitigating these changes and promoting extracellular matrix repair, downregulating proto-oncogenes, and enhancing tumor suppressor expression. </span>These data suggest molecular mechanisms by which alginates provide topical protection against injury during weakly acidic reflux and support a potential role for alginates in prevention of GERD-related carcinogenesis.</p>
Advances in grape and pathogen genomics toward durable grapevine disease resistance
<p>Repository for supplementary Tables to the Expert Views paper: Advances in grape and pathogen genomics toward durable grapevine disease resistance.</p> <p>Table S1. Disease resistance loci identified in grapes.<br>Table S2. Grape pathogen genome assemblies.</p> <p>Funding: <br>This work was funded by the US Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) Award #2022-51181-38240 and partially supported by the Ray Rossi Endowment in Viticulture and Enology and the E.J. Gallo Winery.</p>
Fig. 3. A in Bio-genetic analysis of resistance in tomato to early blight disease, Alternaria alternata
Fig. 3. A two-dimensional plot of the Principal Component Analysis (PCA) of ISSR data showing the clustering of 35 tomato genotypes. On PCA plot, three groups are formed and two other genotypes, namely 111 Falat American and Roma, scattered on the plot and do not fall under any of the groups. The distribution of genetic variation within, and among, groups, was detected using the molecular variance analysis (AMOVA) in GenAlEx software. Genetic variation indices, including observed number of alleles (Na) and effective numbers of alleles (Ne), Shannon's information index (I), Nei's gene diversity (H), percent of polymorphic loci (PPL), were estimated using POP-GENE software.
Fig. 1 in Bio-genetic analysis of resistance in tomato to early blight disease, Alternaria alternata
Fig. 1. Ward's clustering dendrogram of 35 tomato genotypes based on resistance to Alternaria alternata. Note: Cluster Ӏ consisted of moderately susceptible and moderately resistant genotypes, Cluster ӀӀ consisted of resistant genotypes and Cluster ӀӀӀ consisted of highly susceptible genotypes. Disease severity was assessed based on infection percent (0–100) against the scoring scales of: 0, 5, 10, 25, 50, 75, or 100%.
Fig. 2 in Bio-genetic analysis of resistance in tomato to early blight disease, Alternaria alternata
Fig. 2. Grouping of 35 tomato genotypes and lines using the UPGMA method based on complete algorithm and Jaccard's similarity coefficient of 11 ISSR molecular markers. G1 consisted of highly susceptible genotype, G2 consisted of susceptible genotype, G3 consisted of moderately susceptible genotype, G4 consisted of moderately resistant genotype and G5 consisted of resistant genotype. Pearson correlation analysis was carried out to analyze the relationship among the tomato genotypes and response variability and cluster analysis of data was performed using SPSS software.
Improving Insulin Resistance To Treat Non-Alcoholic Fatty Liver Disease: A Pilot Study
ClinicalTrials.gov study NCT02457286. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Insulin Resistance in Nonalcoholic Fatty Liver Disease: A Case Control Study
ClinicalTrials.gov study NCT00637520. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease
ClinicalTrials.gov study NCT03587701. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Tocilizumab in Corticosteroid-Resistant Graves' Orbitopathy (Thyroid Eye Disease)
ClinicalTrials.gov study NCT06367517. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Renal and Systemic Vascular Resistance in Chronic Kidney Disease (CKD)
ClinicalTrials.gov study NCT01380717. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Renal Denervation in End Staged Renal Disease With Resistant Hypertension
ClinicalTrials.gov study NCT02346045. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Low Intensity Resistance Training With Vascular Occlusion in Coronary Heart Disease Patients
ClinicalTrials.gov study NCT03087292. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Pulmonary Microbiota in Patients With Chronic Obstructive Pulmonary Disease Colonized With P. Aeruginosa Resistant to Imipenem
ClinicalTrials.gov study NCT03008746. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Decidua Stroma Cells for Steroid Resistent Acute Graft-versus-host Disease After Allo-HSCT
ClinicalTrials.gov study NCT04118556. IPD Sharing: NO. Countries: 3. Publications: 2.
Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
ClinicalTrials.gov study NCT04067752. IPD Sharing: NO. Countries: 1. Publications: 1.
Carbapenem-resistant Organisms (CRO) Screening From Rectal Swabs in Patients With Hematological Diseases in China
ClinicalTrials.gov study NCT05002582. IPD Sharing: NO. Countries: 1. Publications: 2.
Unilateral Laparoscopic Adrenalectomy for Resistant Hypertension in Patients With Adrenal Diseases
ClinicalTrials.gov study NCT03535532. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.