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1,812 results for “dissection”
Functional dissection of human cardiac enhancers and non-coding de novo variants in congenital heart disease
<p>This is the CHD MPRA motif analysis input file. Please see the detail in : https://github.com/pulab/CHD_DNVs/tree/main/MPRA-Enhancer/CHD_MPRA_project/CHD_MPRA_library</p>
Data from: Dissecting molecular evolution of class 1 integron gene cassettes and their bacterial hosts in suburban creeks via epicPCR
<p>Horizontal gene transfer (HGT) of class 1 integrons plays a key role in the dissemination of antimicrobial resistance (AMR) with clinical consequences worldwide. Class 1 integrons in clinical pathogens are commonly associated with AMR genes and embedded in mobile genetic elements. Over time, these mobile class 1 integrons have spread to diverse environmental bacterial hosts via HGT. We applied a single-cell fusion PCR-based technique to link class 1 integron gene cassette arrays to the phylogenetic markers in their bacterial hosts. Class 1 integrons and associated gene cassettes were detected in <em>Alpha</em>- and <em>Gammaproteobacteria </em>hosts from freshwater samples from two creeks in suburban Sydney. Molecular and bioinformatic characterisations of altered gene cassettes generated new insights into mechanisms that contribute to the evolution of class 1 integron gene cassettes. Here, we present experimental and bioinformatic evidence for key signatures of molecular evolution of gene cassettes, including the gain of a regulatory 5'-untranslated region (5'-UTR), the loss of <em>attC </em>recombination sites between adjacent gene cassettes, and the invasion of a 5'-UTR by an insertion sequence (IS) element. Notably, our experimental testing of a new variant of the aminoglycoside adenylyltransferase encoding <em>aadA11 </em>gene cassette demonstrated that the gain of 5'-UTR contributed to a 3-fold increase in the minimum inhibitory concentration of streptomycin relative to the ancestral reference gene cassette. Understanding these signatures of molecular evolution allows us to explain their effects on AMR phenotypes and offers the potential to better predict evolutionary trajectories of class 1 integrons.</p>
Data from: Dissection of the role of a SH3 domain in the evolution of binding preference of paralogous proteins
<p><span>Protein-protein interactions drive many cellular processes. Some protein interactions are directed by Src homology 3 (SH3) domains that bind proline-rich motifs on other proteins. The evolution of the binding specificity of SH3 domains is not completely understood, particularly following gene duplication. Paralogous genes accumulate mutations that can modify protein functions and, for SH3 domains, their binding preferences. Here, we examined how the binding of the SH3 domains of two paralogous yeast type I myosins, Myo3 and Myo5, evolved following duplication. We found that the paralogs have subtly different SH3-dependent interaction profiles. However, by swapping SH3 domains between the paralogs and characterizing the SH3 domains freed from their protein context, we find that few of the differences in interactions, if any, depend on the SH3 domains themselves. We used ancestral sequence reconstruction to resurrect the pre-duplication SH3 domains and examined, moving back in time, how the binding preference changed. Although the closest ancestor of the two domains had a very similar binding preference as the extant ones, older ancestral domains displayed a gradual loss of interaction with the modern interaction partners when inserted in the extant paralogs. Molecular docking and experimental characterization of the free ancestral domains showed that their affinity with the proline motifs is likely not the cause for this loss of binding. Taken together, our results suggest that the SH3 and its host protein could create intramolecular or allosteric interactions essential for the SH3-dependent PPIs, making domains not functionally equivalent even when they have the same binding specificity. </span></p>
Evaluation of the GORE Conformable TAG® Thoracic Endoprosthesis for Treatment of Acute Complicated Type B Aortic Dissection
ClinicalTrials.gov study NCT00908388. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Multi-omics Dissection of Gut Microbiome Engraftment During FMT
ClinicalTrials.gov study NCT06992453. IPD Sharing: YES. Countries: 1. Publications: 45.
Robotic-Assisted Laparoscopic Extended Pelvic Lymph Node Dissection for Transitional Cell Carcinoma of the Bladder
ClinicalTrials.gov study NCT00963859. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparative Study of Antegrade Versus Retrograde Cerebral Perfusion in Acute Type A Aortic Dissection: A Prospective Study
ClinicalTrials.gov study NCT06870513. IPD Sharing: NO. Countries: 1. Publications: 5.
Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection
ClinicalTrials.gov study NCT00376597. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection
ClinicalTrials.gov study NCT02476357. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness of Bilateral Modified Catheter Antegrade Cerebral Perfusion in Acute Type A Aortic Dissection Surgery
ClinicalTrials.gov study NCT07043777. IPD Sharing: NO. Countries: 1. Publications: 1.
Central Neck Dissection in Patients With Clinical Node Negative Thyroid Cancer
ClinicalTrials.gov study NCT02138214. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Total Thyroidectomy With and Without Prophylactic Central Neck Lymph Node Dissection in People With Low-risk Papillary Thyroid Cancer
ClinicalTrials.gov study NCT02408887. IPD Sharing: YES. Countries: 1. Publications: 3.
Zenith® Dissection Clinical Trial
ClinicalTrials.gov study NCT01568320. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Radical Versus Simple Hysterectomy and Pelvic Node Dissection With Low-risk Early Stage Cervical Cancer
ClinicalTrials.gov study NCT01658930. IPD Sharing: NO. Countries: 11. Publications: 4.
Neurological Complications and ICU Workload After Emergency Repair of Acute Type A Aortic Dissection
ClinicalTrials.gov study NCT07167628. IPD Sharing: NO. Countries: 1. Publications: 10.
LigaSure Small Jaw® Versus Conventional Neck Dissection in Head and Neck Cancer Patients
ClinicalTrials.gov study NCT02597582. IPD Sharing: NO. Countries: 1. Publications: 1.
A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selective Neck Dissection (SND) Followed by Adjuvant Radiation Therapy (+/- Chemotherapy) to th
ClinicalTrials.gov study NCT02159703. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Zenith® Dissection Endovascular System
ClinicalTrials.gov study NCT02094300. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Surgical Resection With or Without Axillary Lymph Node Dissection in Treating Women With Node-Negative Breast Cancer and Sentinel Lymph Node Micrometastases
ClinicalTrials.gov study NCT00072293. IPD Sharing: Not stated. Countries: 10. Publications: 2.
Study to Evaluate the Clinical Performance of the Valiant Thoracic Stent Graft With the Captivia Delivery System (Valiant Captivia) for the Treatment of Acute, Complicated Type B Aortic Dissections
ClinicalTrials.gov study NCT01114724. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.