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171
datasets available to search
ShareScore release 0.9.0
Dataset results
171 results for “fatty acid oxidation”
Alveolar epithelial cells mitigate neutrophilic inflammation in acute lung injury through regulating mitochondrial fatty acid oxidation
GEO Series GSE224354. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
Fatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids [PS-ac-peptide]
GEO Series GSE201052. Homo sapiens. 6 samples. Type: Expression profiling by RT-PCR.
Genome-wide maps of H3K4me3 deposition comparing Ctrl and Fatty acid oxidation restricted (Cpt1b-deficiency) adult cardiomyocyte
GEO Series GSE172412. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Reduced fatty acid synthesis and enhanced oxidation promote human definitive endoderm differentiation by mediating SMAD3 nuclear localization via acetylation
GEO Series GSE217992. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Simultaneous inhibition of SIRT3 and cholesterol homeostasis targets AML stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity
GEO Series GSE224745. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
A mitochondrial long-chain fatty acid oxidation defect in a mouse leads to dysregulation of plasma long-chain acylcarnitines, dysregulation of plasma amino acids, and an increased reliance on glucocor
GEO Series GSE186649. Mus musculus. 50 samples. Type: Expression profiling by high throughput sequencing.
Early weaning induces programmed obesity in rats at adulthood through impairing fatty acid β-oxidation and cholesterol metabolism, which can be mitigated by leucine supplementation
GEO Series GSE203486. Rattus norvegicus. 21 samples. Type: Expression profiling by high throughput sequencing.
C/EBPα confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia [CEBPAOE_QUIZ]
GEO Series GSE226414. Homo sapiens. 12 samples. Type: Expression profiling by array.
Loss of Mitochondrial Fatty Acid Beta-Oxidation Protein Short Chain Enoyl-CoA Hydratase Disrupts Oxidative Phosphorylation Protein Complex Stability and Function
GEO Series GSE200252. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Skeletal muscle mRNA expression in 25 mice with or without genetic defects of mitochondrial fatty acid oxidation (Acadl and Acadvl knockout) using RNA sequencing.
GEO Series GSE186648. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
Mitophagy Mitigates Mitochondrial Fatty Acid β-oxidation Deficient Cardiomyopathy
GEO Series GSE266487. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
FoxO1 Deacetylation Decreases Fatty Acid Oxidation in beta-cells and Sustains Insulin Secretion in Diabetes
GEO Series GSE77652. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization [RNA-seq]
GEO Series GSE250210. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
DNA damage-activated mitochondrial fatty acid oxidation drives senescence
GEO Series GSE272659. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial b-oxidation of adipose-derived fatty acids by osteoblast fuels parathyroid hormone-induced bone formation
GEO Series GSE222173. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Data from: Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders by inducing a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp ⁄NDmcr rats
Increased energy intake and reduced physical activity can lead to obesity, diabetes and metabolic syndrome. Transcriptional modulation of metabolic networks has become a focus of current drug discovery research into the prevention and treatment of metabolic disorders associated with energy surplus and obesity. Tang-Nai-Kang (TNK), a mixture of five herbal plant extracts, has been shown to improve abnormal glucose metabolism in patients with pre-diabetes. Here, we report the metabolic phenotype of SHR.Cg-Leprcp/NDmcr (SHR/cp) rats treated with TNK. Pre-diabetic SHR/cp rats were randomly divided into control, TNK low-dose (1.67 g/kg) and TNK high-dose (3.24 g/kg) groups. After high-dose treatment for 2 weeks, the serum triglycerides and free fatty acids in SHR/cp rats were markedly reduced compared to controls. After 3 weeks of administration, the high dose of TNK significantly reduced the body weight and fat mass of SHR/cp rats without affecting food consumption. Serum fasting glucose and insulin levels in the TNK-treated groups decreased after 6 weeks of treatment. Furthermore, TNK-treated rats exhibited obvious improvements in glucose intolerance and insulin resistance. The improved glucose metabolism may be caused by the substantial reduction in serum lipids and body weight observed in SHR/cp rats starting at 3 weeks of TNK treatment. The mRNA expression of NAD+-dependent deacetylase sirtuin 1 (SIRT1) and genes related to fatty acid oxidation was markedly up-regulated in the muscle, liver and adipose tissue after TNK treatment. Furthermore, TNK promoted the deacetylation of two well-established SIRT1 targets, PPARγ coactivator 1α (PGC1α) and forkhead transcription factor 1 (FOXO1), and induced the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in different tissues. These observations suggested that TNK may be an alternative treatment for pre-diabetes and metabolic syndrome by inducing a gene expression switch toward fat oxidation through the activation of SIRT1 and AMPK signaling.
Palmitate Breath Test to Assess Fatty Acid Oxidation in Non Alcoholic Fatty Liver Disease (NAFLD)
ClinicalTrials.gov study NCT02363309. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids
ClinicalTrials.gov study NCT00328159. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Long-Chain Fatty Acid Oxidation Disorders In-Clinic Disease Monitoring Program
ClinicalTrials.gov study NCT04632953. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Phase 1b Study of the Safety of REN001 in Patients With Fatty Acid Oxidation Disorders
ClinicalTrials.gov study NCT03833128. IPD Sharing: Not stated. Countries: 3. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.