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88 results for “fungicide”
Data from: Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicides
Resistance to medical triazoles in Aspergillus fumigatus is an emerging problem for patients at risk of aspergillus diseases. There are currently two presumed routes for medical triazole-resistance selection: (i) through selection pressure of medical triazoles when treating patients and (ii) through selection pressure from non-medical sterol-biosynthesis-inhibiting (SI) triazole fungicides which are used in the environment. Previous studies have suggested that SI fungicides can induce cross-resistance to medical triazoles. Therefore, to assess the potential of selection of resistance to medical triazoles in the environment, we assessed cross-resistance to three medical triazoles in lineages of A. fumigatus from previous work where we applied an experimental evolution approach with one of five different SI fungicides to select for resistance. In our evolved lines we found widespread cross-resistance indicating that resistance to medical triazoles rapidly arises through selection pressure of SI fungicides. All evolved lineages showed similar evolutionary dynamics to SI fungicides and medical triazoles, which suggests that the mutations inducing resistance to both SI fungicides and medical triazoles are likely to be the same. Whole-genome sequencing revealed that a variety of mutations were putatively involved in the resistance mechanism, some of which are in known target genes.
In-vitro Fungicidal potential of Vitis mustangensis stems and seeds extracts against pathogenic fungi
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Data from: Inorganic fungicides as routinely applied in organic and conventional agriculture can increase palatability but reduce microbial decomposition of leaf litter
1. The application of fungicides is considered an indispensable measure to secure crop production. These substances, however, may unintentionally enter surface waters via runoff, potentially affecting the microbial community. To assess such risks adequately, authorities recently called for suitable test designs involving relevant aquatic microorganisms. 2. We assessed the structural and functional responses of leaf-associated microbial communities, which play a key role in the breakdown of allochthonous leaf material in streams, towards the inorganic fungicides copper (Cu) and elemental sulphur (S). These substances are of particular interest as they are authorized for both conventional and organic farming in many countries of the world. We used the food-choice of the amphipod shredder Gammarus fossarum (indicative for microorganism-mediated leaf palatability) as well as microbial leaf decomposition as functional endpoints. Moreover, the leaf-associated microbial communities were characterized by means of bacterial density, fungal biomass and community composition facilitating mechanistic understanding of the observed functional effects. 3. While Gammarus preferred Cu-exposed leaves over unexposed ones, microbial leaf decomposition was reduced by both Cu and S (up to 30%). Furthermore, Cu-exposure decreased bacterial densities (up to 60%), stimulated the growth of leaf-associated fungi (up to 100%) and altered fungal community composition, while S did not affect any of the assessed structural endpoints. 4. Synthesis and applications. We observed both structural and functional changes in leaf-associated microbial communities at inorganic fungicide concentrations realistic for surface water bodies influenced by conventional and organic farming. Our data hence justify a careful re-evaluation of the environmental safety of the agricultural use of these compounds. Moreover, inclusion of an experimental design similar to the one used in the present study in lower-tier environmental risk assessments of antimicrobial compounds may aid to safeguard the integrity of aquatic microbial communities and the functions they provide.
Fungicide Exposure Assessment Among Apple and Peach Farmers in the Argicultural Health Study
ClinicalTrials.gov study NCT00342394. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Interplay between fungicides and parasites: tebuconazole, but not copper, suppresses infection in a Daphnia-Metschnikowia experimental model
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Data from: Inorganic fungicides as routinely applied in organic and conventional agriculture can increase palatability but reduce microbial decomposition of leaf litter
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Which enemies mediate distance- and density-dependent mortality of tree seeds and seedlings? A meta-analysis of fungicide, insecticide, and exclosure studies
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Data from: Combined exposure to sublethal concentrations of an insecticide and a fungicide affect feeding, ovary development and longevity in a solitary bee
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Data from: Slow and temperature-mediated pathogen adaptation to a non-specific fungicide in agricultural ecosystem
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Data from: Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicides
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Differential hepatic gene expression in zebrafish (Danio rerio) exposed to the fungicide chlorothalonil reveals estrogenicity
GEO Series GSE67600. Danio rerio. 15 samples. Type: Expression profiling by array.
Fungicide resistance RNA-seq on two isolates of Penicillium
GEO Series GSE145355. Penicillium expansum; Penicillium crustosum. 16 samples. Type: Expression profiling by high throughput sequencing.
Non-canonical activation of IRE1α during Candida albicans infection enhances macrophage fungicidal activity
GEO Series GSE244303. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Developmental toxicity of the fungicide Boscalid and primary metabolite M510F01 in zebrafish embryos
GEO Series GSE232317. Danio rerio. 14 samples. Type: Expression profiling by high throughput sequencing.
Effects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows (Pimephales promelas)
GEO Series GSE26958. Pimephales promelas. 23 samples. Type: Expression profiling by array.
The anti-androgenic fungicide triticonazole induces region-specific transcriptional changes in the developing rat perineum and phallus
GEO Series GSE199234. Rattus norvegicus. 93 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional response of the cacao pathogen Moniliophthora perniciosa to a strobilurin fungicide
GEO Series GSE281565. Moniliophthora perniciosa. 90 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide expression profiling of Fusarium graminearum in response to azole fungicide treatment
GEO Series GSE25114. Fusarium graminearum. 6 samples. Type: Expression profiling by array.
Data from: Variable competitive effects of fungicide resistance in field experiments with a plant pathogenic fungus
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Agricultural fungicides to gene expression in Saccharomyces cerevisiae upon exposure to toxic doses
GEO Series GSE9337. Saccharomyces cerevisiae. 15 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.