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157 results for “haemodynamics”
Intracranial haemodynamic relationships in patients with cerebral small vessel disease
<p>Objective</p> <p>To investigate cerebrovascular reactivity (CVR), blood flow, vascular and cerebrospinal fluid (CSF) pulsatility, and their independent relationship to cerebral small vessel disease (SVD) features, in patients with minor ischaemic stroke and MRI evidence of SVD.</p> <p>Methods</p> <p>We recruited patients with minor ischaemic stroke and assessed CVR using Blood Oxygen Level Dependent (BOLD) MRI during a hypercapnic challenge, cerebral blood flow, vascular and CSF pulsatility using phase contrast MRI, and structural MR brain imaging to quantify white matter hyperintensities (WMH) and perivascular spaces (PVS). We used multiple regression to identify parameters associated with SVD features, controlling for patient characteristics.</p> <p>Results</p> <p>53 of 60 patients completed the study with a full dataset (age 68.0±8.8, 74% male, 75% hypertensive). After controlling for age, gender and systolic BP, lower white matter CVR was associated with higher WMH volume (-0.01%/mmHg per log10 increase in WMH volume, p=0.02), basal ganglia PVS (-0.01%/mmHg per point increase in PVS score, p=0.02) and higher venous pulsatility (superior sagittal sinus -0.03%/mmHg, p=0.02, per unit increase in pulsatility index) but not with cerebral blood flow (p=0.58). Lower foramen magnum CSF stroke volume was associated with worse white matter CVR (0.04%/mmHg per ml increase in stroke volume, p=0.04) and more severe basal ganglia PVS (p=0.09).</p> <p>Conclusions</p> <p>Lower CVR, higher venous pulsatility and lower foramen magnum CSF stroke volume indicate that dynamic vascular dysfunctions underpin PVS dysfunction and WMH development. Further exploration of microvascular dysfunction and CSF dynamics may uncover new mechanisms and intervention targets to reduce SVD lesion development, cognitive decline and stroke. </p>
Data for figures and stats in the paper: The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice
<p>Investigating neurovascular coupling in awake rodents is becoming ever more popular due, in part, to our increasing knowledge of the profound impacts that anaesthesia can have upon brain physiology. Although awake imaging brings with it many advantages, we still do not fully understand how voluntary locomotion during imaging affects sensory-evoked haemodynamic responses. In this study we investigated how evoked haemodynamic responses can be affected by the amount and timing of locomotion. Using an awake imaging set up, we used 2D-Optical Imaging Spectroscopy (2D-OIS) to measure changes in cerebral haemodynamics within the sensory cortex of the brain during either 2s whisker stimulation or spontaneous (no whisker stimulation) experiments, whilst animals could walk on a spherical treadmill. We show that locomotion alters haemodynamic responses. The amount and timing of locomotion relative to whisker stimulation is important, and can significantly impact sensory-evoked haemodynamic responses. If locomotion occurred before or during whisker stimulation, the amplitude of the stimulus-evoked haemodynamic response was significantly altered. Therefore, monitoring of locomotion during awake imaging is necessary to ensure that conclusions based on comparisons of evoked haemodynamic responses (e.g., between control and disease groups) are not confounded by the effects of locomotion.</p>
Haemodynamic assessment and the outcomes of aortic valvuloplasty for aortic regurgitation in patients with bicuspid aortic valve
Open the record for dataset details and reuse information.
Mortality Post-TAVI and Correlation With Haemodynamic Parameters.
ClinicalTrials.gov study NCT03769545. IPD Sharing: NO. Countries: 0. Publications: 3.
Continuation of Goal Directed Haemodynamic Optimization in the PACU
ClinicalTrials.gov study NCT04822116. IPD Sharing: NO. Countries: 1. Publications: 0.
Cerebral Haemodynamics in Transient Ischaemic Attack
ClinicalTrials.gov study NCT03886129. IPD Sharing: NO. Countries: 1. Publications: 0.
Invasive and Non-invasive Haemodynamic Assessment of Pulmonary Hypertension in Chronic Kidney Disease Patient
ClinicalTrials.gov study NCT07052968. IPD Sharing: NO. Countries: 0. Publications: 2.
The Effect of Lactate Clearance Oriented Haemodynamic Therapy on the Outcome of Patients With Septic Shock
ClinicalTrials.gov study NCT02566460. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Early Haemodynamic Optimization Using Preload Dependence During Septic Shock = EHOSS-1
ClinicalTrials.gov study NCT01972828. IPD Sharing: Not stated. Countries: 0. Publications: 1.
The Effects of Scalp Block on Haemodynamic Response and Postoperative Pain in Posterior Fossa Surgery
ClinicalTrials.gov study NCT02852382. IPD Sharing: UNDECIDED. Countries: 0. Publications: 6.
Scar Location and Acute Haemodynamic Response to MultiPoint Pacing Study in Patients With Ischemic Cardiomyopathy
ClinicalTrials.gov study NCT04066738. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cerebral Haemodynamic Changes During Cognitive Testing: A fTCD Study
ClinicalTrials.gov study NCT03134963. IPD Sharing: NO. Countries: 1. Publications: 0.
Data for figures and stats in the paper: The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice
Open the record for dataset details and reuse information.
Intracranial haemodynamic relationships in patients with cerebral small vessel disease
Open the record for dataset details and reuse information.
Low and Moderete Flow Anaesthesia on Haemodynamics
ClinicalTrials.gov study NCT06871371. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Association of Intraoperative Haemodynamic and Postoperative Complications in Type A Aortic Dissection Surgery
ClinicalTrials.gov study NCT06440161. IPD Sharing: NO. Countries: 1. Publications: 0.
An Algorithm for Intra-operative Goal-directed Haemodynamic Management in Non-cardiac Surgery
ClinicalTrials.gov study NCT01384097. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Incidence , Risk Factors and Outcomes of Haemodynamic Instability and Cardiac Arrest During Spine Surgery
ClinicalTrials.gov study NCT05131854. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluating the Safety, Pharmacokinetics and Haemodynamic Effect of a Slow Release Oral Formulation of Milrinone
ClinicalTrials.gov study NCT01849094. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Sevoflurane on Haemodynamics
ClinicalTrials.gov study NCT06707077. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.