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69 results for “head model”
Head-Down Tilt As a Model for Intracranial and Intraocular Pressures, and Retinal Changes during Spaceflight (Optic Nerve, MRI)
This ground-based program was intended to address the etiology of visual system structural and functional changes observed in astronauts during both inflight and postflight periods. Using the well-documented rat hindlimb suspension (HLS) model, functionally equivalent to human head-down bedrest, we examined the relationship between cephalic fluid shifts resulting from long-duration G-unloading and the regulation of intracranial and intraocular pressures, as well as the effects these same cephalic fluid shifts have on visual system structure and function. Animals were chronically instrumented with biotelemetry to continuously measure intracranial pressure. Additionally, regular intraocular pressure measurements were made by tonometry during long-term exposure to cephalic fluid shifts induced by suspension. MRI images visualizing the visual system morphology were collected from HLS and control animals at regular intervals. Retinal morphology and ultrastructure were examined at specified intervals both during HLS and post-HLS recovery by ophthalmic examinations. This program utilized both male and female subjects in order to examine possible sex differences in these responses. We also examined the possible contributory factors of aging and elevated atmospheric carbon dioxide (hypercapnia) on these responses of the visual system. Further, in addition to mimicking the effects of long duration exposure to microgravity through the use of the HLS model, we examined the responses of our measured outcomes during long-term recovery in the post-HLS period. Collectively, these data will help us to develop a model to both understand and predict the etiology of changes in visual structure and function in astronauts exposed to the microgravity of spaceflight and during postflight recovery. This study investigated the development of a translational mammalian model within the context of hindlimb unloading, sex, and aging by which the data generated using this model can facilitate the development of countermeasures to alleviate any visual system decrements arising from exposure to the microgravity spaceflight environment. This study derives results from Magnetic Resonance Imaging assay using Optic Nerve tissue. This study is related to results found in OSD-679 (eye) and OSD-681(subcutaneous tissue and subdural space).
Head-Down Tilt As a Model for Intracranial and Intraocular Pressures, and Retinal Changes during Spaceflight (Subcutaneous Tissue and Subdural Space, Body Temperature and Intracranial Pressure Biotelemetry)
This ground-based program was intended to address the etiology of visual system structural and functional changes observed in astronauts during both inflight and postflight periods. Using the well-documented rat hindlimb suspension (HLS) model, functionally equivalent to human head-down bedrest, we examined the relationship between cephalic fluid shifts resulting from long-duration G-unloading and the regulation of intracranial and intraocular pressures, as well as the effects these same cephalic fluid shifts have on visual system structure and function. Animals were chronically instrumented with biotelemetry to continuously measure intracranial pressure. Additionally, regular intraocular pressure measurements were made by tonometry during long-term exposure to cephalic fluid shifts induced by suspension. MRI images visualizing the visual system morphology were collected from HLS and control animals at regular intervals. Retinal morphology and ultrastructure were examined at specified intervals both during HLS and post-HLS recovery by ophthalmic examinations. This program utilized both male and female subjects in order to examine possible sex differences in these responses. We also examined the possible contributory factors of aging and elevated atmospheric carbon dioxide (hypercapnia) on these responses of the visual system. Further, in addition to mimicking the effects of long duration exposure to microgravity through the use of the HLS model, we examined the responses of our measured outcomes during long-term recovery in the post-HLS period. Collectively, these data will help us to develop a model to both understand and predict the etiology of changes in visual structure and function in astronauts exposed to the microgravity of spaceflight and during postflight recovery. This study investigated the development of a translational mammalian model within the context of hindlimb unloading, sex, and aging by which the data generated using this model can facilitate the development of countermeasures to alleviate any visual system decrements arising from exposure to the microgravity spaceflight environment. This study derives results from Biotelemetry (body temperature and intraocular pressure) assay using implants in the subcutaneous tissue and subdural space. This study is related to results found in OSD-679 (eye) and OSD-680 (optic nerve).
Prenatal fetal head and placental gene expression in a mouse model of advanced maternal age
GEO Series GSE276507. Mus musculus. 31 samples. Type: Expression profiling by array.
A Novel Orthotopic Mouse Model of Head and Neck Cancer and Lymph Node Metastasis
GEO Series GSE41893. Homo sapiens. 12 samples. Type: Expression profiling by array.
Effect of regorafenib, anti-PD1, and anti-CD40 agonist in Head and Neck Squamous Cell Carcinoma [HNSCC_model]
GEO Series GSE248153. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Development of the embryonic head: Modelling the impact of WNT signalling activity on the differentiation of epiblast cells to neural progenitors [Dkk]
GEO Series GSE103365. Mus musculus. 12 samples. Type: Expression profiling by array.
Gene expression profile at single cell level of genetically defined organoid models in neoplastic evolution of head and heck squamous cell carcinoma
GEO Series GSE286449. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Effect of regorafenib, anti-PD1, and anti-CD40 agonist in Head and Neck Squamous Cell Carcinoma [4NQO_model]
GEO Series GSE248154. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Automated Head Tissue Modelling Based on Structural Magnetic Resonance Images for Electroencephalographic Source Reconstruction"
<p><strong>SCORING SEGMENTATIONS</strong></p> <ul> <li>Qualitative segmentation scores by two raters (rater1; rater2).</li> <li>Scale: excellent (4); good (3); doubtful (2) and failed (1).</li> </ul> <p> </p> <p><strong>DATABASES</strong></p> <ul> <li>IXI database, Imperial College of London (<a href="https://brain-development.org/ixi-dataset/">https://brain-development.org/ixi-dataset/</a>)</li> <li>Autism Brain Imaging Data Exchange (ABIDE) database (<a href="http://fcon_1000.projects.nitrc.org">http://fcon_1000.projects.nitrc.org</a>)</li> <li>SchizConnect database (<a href="http://schizconnect.org">http://schizconnect.org</a>)</li> </ul> <p> </p> <p><strong>SEGMENTATION METHODS</strong></p> <ul> <li>MR-TIM (Taberna et al., 2021), green rows</li> <li>WTS (Liu et al., 2017), red rows</li> </ul> <p> </p> <p><strong>TABLES</strong></p> <p><strong>IXI_young </strong></p> <ul> <li>20 MRI from the IXI database, participants 20–35 years old;</li> <li>MR scanners: Philips Intera 3.0T (HH); Philips Gyroscan Intera 1.5T (G)</li> </ul> <p><strong>IXI_older</strong></p> <ul> <li>20 MRI from the IXI database, participants 60–75 years old;</li> <li>MR scanners: Philips Intera 3.0T (HH); Philips Gyroscan Intera 1.5T (G)</li> </ul> <p><strong>ABIDE</strong></p> <ul> <li>10 MRI from the ABIDE database, participants 18-25 years old;</li> <li>MR scanner: Philips Achieva 3.0T</li> </ul> <p><strong>SchizConnect</strong></p> <ul> <li>10 MRI from the SchizConnect database, participants 19-66 years old;</li> <li>MR scanner: Siemens Trio Tim 3.0T</li> </ul> <p> </p> <p><strong>REFERENCES</strong></p> <p>Liu, Q., Farahibozorg, S., Porcaro, C., Wenderoth, N., & Mantini, D. (2017). Detecting large-scale networks in the human brain using high-density electroencephalography. Hum Brain Mapp, 38(9), 4631-4643. doi:10.1002/hbm.23688</p> <p>Taberna, G. A., Samogin, J., & Mantini, D. (2021). Automated Head Tissue Modelling Based on Structural Magnetic Resonance Images for Electroencephalographic Source Reconstruction. Neuroinformatics. doi:10.1007/s12021-020-09504-5</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.