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730 results for “high fat diet”
Figure 2 from: Issa R, Abu Samak M, Abbas MM, Al-Qaisi T, Obeidat R, Ghanim B, Qinna N (2024) Effect of Equisetum ramosissimum Desf. on body weight and Leptin/Ghrelin in standard and high-fat diet. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117823
Figure 2 Percent Body Weight change in healthy and obese animals treated with E. ramosissimum extract. Comparison of weight change was made between: Standard Diet (SD); SD receiving Plant extract (SDP); High-fat Diet (HD); and HD receiving Plant extract (HDP). ***: p<0.001 in comparison to SD, as calculated through t-test.
Figure 3 from: Issa R, Abu Samak M, Abbas MM, Al-Qaisi T, Obeidat R, Ghanim B, Qinna N (2024) Effect of Equisetum ramosissimum Desf. on body weight and Leptin/Ghrelin in standard and high-fat diet. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117823
Figure 3 Serum concentrations of leptin and ghrelin and their corresponding ratios. Serum concentrations of leptin and ghrelin and their corresponding ratios were quantified for animals receiving Standard Diet (SD); SD receiving Plant extract (SDP); High-fat Diet (HD); and HD receiving Plant extract (HDP). Ratios of leptin/ghrelin were calculated and presented in normalized values to the standard body levels (right y-axis), specifically per animals receiving SD. **: p<0.01; *p<0.05 in comparison to SD.
Figure 1 from: Issa R, Abu Samak M, Abbas MM, Al-Qaisi T, Obeidat R, Ghanim B, Qinna N (2024) Effect of Equisetum ramosissimum Desf. on body weight and Leptin/Ghrelin in standard and high-fat diet. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117823
Figure 1 Total Phenol and Flavonoid content in E. ramosissimum extract. Extracts are quantified against equivalent quantities of reference standards, specifically Gallic acid and quercetin, respectively.
Impacts of a high fat diet on the metabolic profile and the phenotype of atrial myocardium in mice
<p>Aims: Obesity, diabetes and metabolic syndromes are risk factors of atrial fibrillation (AF). We tested the hypothesis that metabolic disorders have a direct impact on the atria favoring the formation of the substrate of AF.</p> <p>Methods & Results: Untargeted metabolomic and lipidomic analysis was used to investigate the consequences of a prolonged high fat diet (HFD) on mouse atria. Atrial properties were characterized by measuring mitochondria respiration in saponin-permeabilized trabeculae, by recording action potential with glass microelectrodes in trabeculae and ionic currents in myocytes using the perforated configuration of patch clamp technique and by several immuno-histological and biochemical approaches. After 16 weeks of HFD, obesogenic mice showed a vulnerability to AF. The atrial myocardium acquired an adipogenic and inflammatory phenotypes. Metabolomic and lipidomic analysis revealed a profound transformation of atrial energy metabolism with a predominance of long-chain lipid accumulation and beta-oxidation activation in the obese mice. Mitochondria respiration showed an increased use of palmitoyl-CoA as energy substrate. Action potentials were short duration and sensitive to the K-ATPdependent channel inhibitor, whereas K-ATP current was enhanced in isolated atrial myocytes of obese mouse.</p> <p>Conclusion:<em><strong> </strong></em>HFD transforms energy metabolism, causes fat accumulation, and induces electrical remodeling of the atrial myocardium of mice that become vulnerable to AF.</p> <p>Translational perspective: Understanding the link between metabolic diseases and atrial fibrillation is of major importance. One hypothesis claims that, in addition to shared co-morbidities, metabolic disorders favor the substrate of atrial fibrillation. Here we show that after prolonged high fat diet, the atrial myocardium becomes adipogenic, inflamed and vulnerable to atrial fibrillation. This tissue remodeling appears to result from an unbalance between uptake and oxidation of fatty acid resulting in long-chain lipid storage, activation metabolic-sensitive potassium channel and action potential shortening. Therefore, diet appears to be an important link between metabolic disorders and atrial fibrillation.</p>
Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
<p>Abstract. The healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to mitochondrial dysfunction and cardiomyopathy. A principal regulator of cardiac metabolism is 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2), which is a central driver of glycolysis. We hypothesized that increasing PFK-2 activity could mitigate cardiac dysfunction induced by high fat diet (HFD). Wild type (WT) and cardiac-specific transgenic mice expressing PFK-2 (Glyco<sup>Hi</sup>) were fed a low fat or HFD for 16-weeks to induce metabolic dysfunction. Metabolic phenotypes were determined by measuring mitochondrial bioenergetics and performing targeted quantitative proteomic and metabolomic analysis. Increasing cardiac PFK-2 had beneficial effects on cardiac and mitochondrial function. Unexpectedly, Glyco<sup>Hi</sup> mice also exhibited sex-dependent systemic protection from HFD, including increased glucose homeostasis. These findings support improving glycolysis via PFK-2 activity can mitigate mitochondrial and functional changes that occur with metabolic syndrome.</p> <p>There are two types of data in this upload, proteomics and metabolomics.</p> <p>The proteomics data are raw files acquired on a tsq quantiva triple quadrupole mass spectrometer in the SRM mode at OMRF. Each file is panel of protein assays. Please contact Mike Kinter with questions.</p> <p>The metabolomics data are more processed data files as described in the paper. Please contact Haiwei Gu with questions.</p>
The Effect of 6 Weeks Saturated and Polyunsaturated High-Fat Diets on Insulin Sensitivity and Health Parameters
ClinicalTrials.gov study NCT03561363. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Clinical Trial to Compare The Pharmacokinetics of A Pregabalin GLARS-NF1 Tablet 150mg With Immediate Release Formulation and to Assess The Effect of High Fat Diet in Healthy Male Subjects
ClinicalTrials.gov study NCT02326987. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Data from: High fat diet induces microbiota-dependent silencing of enteroendocrine cells
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Data from: Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes
Open the record for dataset details and reuse information.
Impacts of a high fat diet on the metabolic profile and the phenotype of atrial myocardium in mice
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High-Fat Diet Driven Post-Operative Colon Cancer Recurrence is Dependent upon Genetic Susceptibility to Deoxycholic Acid [tRNA-seq]
GEO Series GSE288276. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of hepatocyte-restricted Fra-1 overexpression on hepatic gene expression in High-fat diet (HFD) fed mice
GEO Series GSE52273. Mus musculus. 5 samples. Type: Expression profiling by array.
MicroRNA expression differences in adipose tissue between high and low fat diet mice
GEO Series GSE32419. human gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Human alphaherpesvirus 1; Homo sapiens; Human betaherpesvirus 5; Murid gammaherpesvirus 4; Betapolyomavirus hominis. 3 samples. Type: Non-coding RNA profiling by array.
Gene expression profile at single cell level of bone marrow and brain cells from young adult and aged mouse after chewing diet (CD) and long-term high-fat diet (HFD) feeding
GEO Series GSE217560. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profilling of liver from C57BL/6 wildtype and PPARα-knockout mice treated with PFOA and GenX after 20 weeks of high-fat diet
GEO Series GSE212294. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Acquired paternal inheritance fatty liver transcriptomes induced by high-fat diet
GEO Series GSE111909. Gallus gallus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analyses of skeletal muscle in αB-crystallin/HspB2 knockout and wild-type mice on a normal or high fat diet
GEO Series GSE66557. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, heart, and skeletal muscle tissue from mice fed high-fat, high-sugar diet. [Liver]
GEO Series GSE266569. Mus musculus. 481 samples. Type: Expression profiling by high throughput sequencing.
Maternal high-fat diet alters the characteristics of astrocytes and worsens the outcome of stroke in rat offspring, which improves after FGF21 administration
GEO Series GSE189679. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A maternal high-fat diet induces fetal origins of NASH-HCC in mice
GEO Series GSE183360. Mus musculus. 4 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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