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5,047 results for “histones”
Fig. 4 The probability density P in Range of a Palearctic uraniid moth Eversmannia exornata (Lepidoptera: Uraniidae: Epipleminae) was split in the Holocene, as evaluated using histone H1 and COI genes with reference to the Beringian disjunction in the genus Oreta (Lepidoptera: Drepanidae)
Fig. 4 The probability density P of the Bayesian coalescent estimation of the time of existence of the most recent common ancestors, T, of the recent representatives of O. rosea (A) and of the three northernmost species of the genus Oreta occurring at opposite sides of the Pacific: O. rosea (North America), O. pulchripes and O. paki (East Asia) (B)
Fig.2 in Contributions to Trachelyopterus (Siluriformes: Auchenipteridae) species diagnosis by cytotaxonomic autapomorphies: from U2 snRNA chromosome polymorphism to rDNA and histone gene synteny
Fig.2 Karyotypes of T. striatulus (a), T. galeatus (b), and Trachelyopterus aff. galeatus (c). m: metacentric; sm: submetacentric; st: subtelocentric; a: acrocentric. Probes: 18S rDNA, 5S rDNA and U2 snRNA (green signal); and H3/H4 histone genes (red signal) µm. Bar=5 µm
Fig. 1 in Contributions to Trachelyopterus (Siluriformes: Auchenipteridae) species diagnosis by cytotaxonomic autapomorphies: from U2 snRNA chromosome polymorphism to rDNA and histone gene synteny
Fig. 1 Karyotypes of Trachelyopterus porosus (a), T. galeatus coriaceus (b), and Trachelyopterus aff. coriaceus (c). m: metacentric; sm: submetacentric; st: subtelocentric; a: acrocentric. Probes: 18S rDNA, 5S rDNA and U2 snRNA (green signal); and H3/H4 histone genes (red signal). Bar= 5 µm
Fig. 2 in Estimating range disjunction time of the Palearctic Admirals (Limenitis L.) with COI and histone H1 genes
Fig. 2 The consensus Bayesian tree for Limenitis spp. based on 699 bp of the histone H1 gene sequence. Posterior probabilities are indicated at nodes; mean substitution rates (sites/mya) are indicated above branches. Designations of specimens are as in Table 1
Fig. 3 Haplotypic networks for the studied histone H1 in Estimating range disjunction time of the Palearctic Admirals (Limenitis L.) with COI and histone H1 genes
Fig. 3 Haplotypic networks for the studied histone H1 gene (a–c) and COI fragment (d) of L. camilla (a–b) and L. helmanni (c–d) from the eastern and western parts of their ranges; b shows representation of combinations of histone H1 gene haplotypic variants in individuals of L. camilla
Fig. 1 in Estimating range disjunction time of the Palearctic Admirals (Limenitis L.) with COI and histone H1 genes
Fig. 1 Disjunction of the Limenitis spp. ranges in the Palearctic. The borders of the ranges of L. camilla, L. helmanni and L. sydyi are marked with purple, green and red lines, respectively; the dots indicate sampling localities
Supplementary tables for: CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of brain disorders
<p>Supplementary tables for: CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of brain disorders. </p> <p>Supplementary Table 1: S1_AD_H3K27ac_Marzi2018_CHAS_analysis.xls, includes the sample metadata, differentially acetylated regions when controlling for CHAS scores and CHAS-MF cell type proportions, GO enrichment analysis results using the two sets of differentially acetylated regions. </p> <p>Supplementary Table 2: S2_PD_H3K27ac_Toker2022_CHAS_analysis.xls, includes the sample metadata, differentially acetylated regions when controlling for CHAS scores and CHAS-MF cell type proportions.</p> <p>Supplementary Table 3: S3_ASD_H3K27ac_Sun2016_CHAS_analysis.xls, includes the sample metadata, differentially acetylated regions when controlling for CHAS scores and CHAS-MF cell type proportions for the prefrontal cortex and the cerebellum, GO enrichment analysis results using the two sets of differentially acetylated regions in the prefrontal cortex. </p> <p>Supplementary Table 4: S4_SCZ_BPD_H3K27ac_Girdhar2022_CHAS_analysis.xls, includes the sample metadata, differentially acetylated regions when controlling for CHAS scores and CHAS-MF cell type proportions, GO enrichment analysis results using the two sets of differentially acetylated regions. </p> <p> </p> <p> </p> <p> </p> <p> </p>
Dataset: lhp1 FLC-Venus time course imaging – Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory
<p>The histone modification H3K27me3 plays a central role in Polycomb-mediated epigenetic silencing. H3K27me3 recruits and allosterically activates Polycomb Repressive Complex 2 (PRC2), which adds this modification to nearby histones, providing a read/write mechanism for inheritance through DNA replication. However, for some PRC2 targets, a purely histone-based system for epigenetic inheritance may be insufficient. We address this issue at the Polycomb target Flowering Locus C (FLC) in Arabidopsis thaliana, as a narrow nucleation region of only ~three nucleosomes within FLC mediates epigenetic state switching and subsequent memory over many cell cycles. To explain the memory's unexpected persistence, we introduce a mathematical model incorporating extra protein memory storage elements with positive feedback that persist at the locus through DNA replication, in addition to histone modifications. Our hybrid model explains many features of epigenetic switching/memory at FLC and encapsulates generic mechanisms that may be widely applicable.</p>
Fig. 6 in Sesquiterpenes with diverse skeletons from histone deacetylase inhibitor modified cultures of the basidiomycete Cyathus stercoreus (Schwein.) De Toni HFG134
Fig. 6. (A) The four possible stereoisomers of 9. (B), (C) The comparisons of the experimental CD and calculated ECD of 9.
Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia
ClinicalTrials.gov study NCT06726941. IPD Sharing: Not stated. Countries: 1. Publications: 3.
GROSS-HIST : Quantification of the Main Circulating Histones During Normal Pregnancy and Pregnancies With Placenta-mediated Complications
ClinicalTrials.gov study NCT04205383. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Vorinostat (MK0683), an Histone Deacetylase (HDAC) Inhibitor in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma (MK-0683-095)
ClinicalTrials.gov study NCT00773838. IPD Sharing: YES. Countries: 0. Publications: 1.
A Dose Escalation Study of the Histone Deacetylase Inhibitor (HDACi) JNJ 26481585 in Combination With VELCADE (Bortezomib) and Dexamethasone for Patients With Relapsed Multiple Myeloma
ClinicalTrials.gov study NCT01464112. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate the Safety and Effect of HIVconsv Vaccines in Combination With Histone Deacetylase Inhibitor Romidepsin on the Viral Rebound Kinetic After Treatment Interruption in Early Treated HIV
ClinicalTrials.gov study NCT02616874. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Investigational Study of a Histone Deacetylase (HDAC) Inhibitor Plus Targretin in Cutaneous T-Cell Lymphoma Patients (0683-016)(TERMINATED)
ClinicalTrials.gov study NCT00127101. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Dataset: lhp1 FLC-Venus time course imaging – Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory
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Data from: The evolutionary dynamics of ribosomal genes, histone H3, and transposable Rex elements in the genome of Atlantic snappers
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Data from: Cryo-electron tomography reveals the multiplex anatomy of condensed native chromatin and its unfolding by histone citrullination
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Data from: Control of proline accumulation under drought via a novel pathway comprising the histone methylase CAU1 and the transcription factor ANAC055
Proline plays a crucial role in the drought stress response in plants. However, there are still gaps in our knowledge about the molecular mechanisms that regulate proline metabolism under drought stress. Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Δ1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance. We determined that the transcript level of CAU1 decreased while that of ANAC055 (encoding a transcription factor) increased in wild-type Arabidopsis under drought stress. Further analyses showed that CAU1 bound to the promoter of ANAC055 and suppressed its expression via H4R3sme2-type histone methylation in the promoter region. Thus, under drought stress, a decreased level of CAU1 led to an increased transcript level of ANAC055, which induced the expression of P5CS1 and increased proline level independently of CAS. Drought tolerance and the level of proline were found to be decreased in the cau1 anac055 double-mutant, while proline supplementation restored drought sensitivity in the anac055 mutant. Our results reveal the details of a novel pathway leading to drought tolerance mediated by CAU1.
Genome-wide profiling of histone H3K4me3 and H3K27me3 modifications in individual bovine blastocysts by NTU-CAT
<p>BAM and corresponding BW files generated by NON-TiE-UP CUT&Tag (NTU-CAT).</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.