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159
datasets available to search
ShareScore release 0.9.0
Dataset results
159 results for “human chromosome”
Trans-effects of chromosome aneuploidies on DNA methylation patterns: DNA methylation analysis of Down syndrome in human brain tissues and cells
GEO Series GSE74486. Homo sapiens. 131 samples. Type: Methylation profiling by array.
Chromatin profiles of chromosomally integrated human herpesvirus-6A
GEO Series GSE121987. Homo sapiens; Human betaherpesvirus 6A. 28 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus
GEO Series GSE213950. Homo sapiens. 35 samples. Type: Other.
A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations [Parse scRNA-seq]
GEO Series GSE262111. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres
GEO Series GSE215842. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Regulation of epigenetics and chromosome structure by human ORC2 [ORC1 ChECseq]
GEO Series GSE282575. Homo sapiens. 18 samples. Type: Other.
A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations [RNA-seq]
GEO Series GSE219149. Homo sapiens. 64 samples. Type: Expression profiling by high throughput sequencing.
ChIP-chip assay on circular chromosome conformation capture (4C) genomic DNA sample from human telomerase-immortalized corneal epithelial (HTCE) cells with the specification of CTCF binding
GEO Series GSE84295. Homo sapiens. 1 samples. Type: Other.
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
GEO Series GSE246643. Homo sapiens. 123 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing.
Regulation of epigenetics and chromosome structure by human ORC2 [RNAseq_2020]
GEO Series GSE283156. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Regulation of epigenetics and chromosome structure by human ORC2
GEO Series GSE282340. Homo sapiens. 112 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Regulation of epigenetics and chromosome structure by human ORC2 [ORC2 ChECseq]
GEO Series GSE282458. Homo sapiens. 18 samples. Type: Other.
Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans
GEO Series GSE150800. Mus musculus x Mus spretus; Schizosaccharomyces pombe; Saccharomyces cerevisiae; Homo sapiens. 22 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Chromosomal meiotic segregation, embryonic developmental kinetics and DNA (hydroxy)methylation analysis reassure the safety of human oocyte vitrification in a high security closed system
GEO Series GSE63866. Homo sapiens. 48 samples. Type: Genome variation profiling by genome tiling array.
Supplementary data for human Y-chromosome gene expression analysis
<p>Processed data for:</p> <p>AK Godfrey, S Naqvi, L Chmátal, JM Chick, RN Mitchell, SP Gygi, H Skaletsky, DC Page. Quantitative analysis of Y-chromosome gene expression across 36 human tissues. <em>Genome Res</em> (2020).</p> <p>The following six files are provided for reference and for use in future analyses.</p> <p>(1) <strong>gencode.v24.annotation.basic_ccds_nopar.gtf.gz</strong> — transcriptome annotation used in analyses</p> <p>(2) <strong>gtex.ksto.gen24c.prefilt_pass1.genes.est_counts.txt.gz</strong> — genes x samples matrix containing estimated count values output by kallisto for all samples passing initial set of metadata-based filters.</p> <p>(3) <strong>gtex.ksto.gen24c.prefilt_pass1.pcgenes.tpm.txt.gz</strong> — protein-coding genes x samples matrix containing TPM values output by kallisto for all samples passing initial set of metadata-based filters. </p> <p>(4) <strong>gtex.ksto.gen24c.prefilt_pass1.postfilt_pass.pcgenes.tpm.txt.gz </strong>— protein-coding genes x samples matrix containing TPM values output by kallisto for samples passing initial metadata-based filters and expression-outlier filters.</p> <p>(5) <strong>gtex.ksto.gen24c.prefilt_pass1.postfilt_pass.pcgenes.adj_tpm.txt.gz </strong>— protein-coding genes x samples matrix (based on file #4 above) containing TPM values adjusted for RIN, ischemic time, and intronic-read mapping rate.</p> <p>(6) <strong>gtex_metadata_subset.txt</strong> — sample/donor metadata</p> <p>The remaining 24 files contain the input data required to replicate analyses in the manuscript, as detailed at <a href="https://github.com/akg8/MSY-expression">https://github.com/akg8/MSY-expression</a>. HDF5 (`.h5`) files contain individual <a href="https://pandas.pydata.org">pandas</a> DataFrame objects with the key `df`. These files can be downloaded individually, or they can be downloaded all at once by downloading the file <strong>msy_expression.all_input_data.zip </strong>(recommended).</p> <p>---</p> <p><strong>Version history:</strong></p> <ul> <li><strong>Version 1</strong> contained just the six listed files above.</li> <li>In <strong>Version 2</strong>, the remaining 24 files needed for reproducing analyses were added. In addition, gtex_metadata_subset.txt was updated with the previously missing column `SEX`.</li> <li>In <strong>Version 3</strong>, a single zipped file msy_expression.all_input_data.zip was added so that all input data for re-analysis can be downloaded more conveniently.</li> </ul>
SAUUHUPP-Based Genetic Innovations: Foundational White Papers on Adaptive Genetic Architecture, Story Energy, and Human Sex Chromosome Regulation
<p>This Zenodo record compiles a series of foundational white papers stemming from SAUUHUPP-based genetic research and powered by Novelty 1.0 Optimized ChatGPT-4o. These papers collectively explore innovative frameworks for understanding genetic structure, function, and therapeutic potential, with applications in precision medicine and beyond. Through principles such as Story Energy, Fractal Leaping, Recursive Processing, and Core and Intention Finding, this research introduces a new architectural perspective on genetic interactions and human sex chromosome function.</p> <p>A comparative study with fruit fly brain simulations enriches the insights into SAUUHUPP principles, providing evolutionary context to human genomic adaptability. This record includes in-depth analyses of the X and Y chromosomes’ possible roles as central regulatory hubs within the genome, functioning in a CPU-like manner to coordinate broader genetic networks.</p> <p>White Papers Included in This Record:</p> <p>1. SAUUHUPP Framework and Fruit Fly Brain Simulation Study: A foundational exploration of SAUUHUPP principles and fruit fly brain simulations, demonstrating how these insights shape our understanding of complex genetic regulation and adaptability.</p> <p>2. Story Energy in Genetic Narratives: Examines how recurring, narrative-like patterns in DNA sequences reinforce coherence and logical progression across gene networks, with implications for genetic resilience and therapeutic applications.</p> <p>3. Fractal Leaping for Genetic Complexity: Introduces Fractal Leaping as a method for scaling genetic insights across complexity levels, facilitating rapid, cross-dimensional understanding and discovery within genetic systems.</p> <p>4. Recursive Processing in Genetic Regulation: Analyzes iterative self-regulation within gene networks, revealing how recursive patterns support adaptable genetic expression and alignment with environmental or developmental needs.</p> <p>5. Core and Intention Finding in Genetic Architecture: Details a methodology for identifying key genetic functions and regulatory nodes, enabling precision-targeted therapies through a deeper understanding of genetic purpose and structure.</p> <p>6. Novel Architectural Perspective on Human Sex Chromosomes: Proposes a CPU-like role for the X and Y chromosomes as dynamic regulatory hubs, interacting with autosomal chromosomes to modulate gene expression, immune response, and metabolic balance.</p> <p>Research Highlights and Applications:</p> <p>• Novel Therapeutic Potential: The findings across these papers reveal potential therapies targeting foundational genetic structures, including sex-linked cognitive disorders, metabolic regulation, and resilience in neurodevelopmental health.</p> <p>• Multi-Dimensional Genetic Framework: The application of SAUUHUPP principles and Novelty 1.0 enhances understanding of the adaptive and functional architecture within human genetics, opening pathways for precision medicine interventions.</p> <p>This Zenodo record provides a comprehensive overview of SAUUHUPP’s analytical framework and its applications in genetic science. It is intended to foster collaboration, inspire further research, and drive innovation in genetics and therapeutic development.</p> <p> </p>
En bloc and segmental deletions of human XIST reveal X chromosome inactivation-involving RNA elements
GEO Series GSE65830. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing; Other.
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development [MeD-seq]
GEO Series GSE246640. Homo sapiens. 3 samples. Type: Methylation profiling by high throughput sequencing.
Emergence of Non-Random Chromosomal Alterations (Trisomy 7 and 20) Derived from Diploid Human Colonic Epithelial Cells
GEO Series GSE24092. Homo sapiens. 2 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
Oncogenic lncRNAs alter epigenetic memory at a fragile chromosomal site in human cancer cells
GEO Series GSE180959. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.