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108
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ShareScore release 0.9.0
Dataset results
108 results for “human microbiota”
Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures
GEO Series GSE137338. Homo sapiens. 111 samples. Type: Expression profiling by high throughput sequencing.
Gut Microbiota from Human Autism Spectrum Disorder Induces Behavioral Deficits in Mice
GEO Series GSE109827. Mus musculus. 69 samples. Type: Expression profiling by high throughput sequencing.
Human gut derived-organoids as model to study gluten response and effects of microbiota bioproducts in celiac disease
GEO Series GSE113492. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on Overweight and Gut Microbiota in Human: Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
GEO Series GSE202489. Homo sapiens. 118 samples. Type: Other.
Predicting a human gut microbiota's response to diet in gnotobiotic mice.
GEO Series GSE26687. Blautia hydrogenotrophica DSM 10507; Escherichia coli str. K-12 substr. MG1655; Marvinbryantia formatexigens DSM 14469; Collinsella aerofaciens ATCC 25986; Bacteria; [Clostridium] symbiosum; Bacteroides thetaiotaomicron VPI-5482; Bacteroides ovatus ATCC 8483; Bacteroides caccae ATCC 43185; Agathobacter rectalis ATCC 33656; Desulfovibrio piger GOR1. 490 samples. Type: Expression profiling by high throughput sequencing; Other.
Data from: Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome
The human gut microbiota is an important metabolic organ. However, little is known about how its individual species interact, establish dominant positions, and respond to changes in environmental factors such as diet. In the current study, gnotobiotic mice colonized with a simplified model microbiota composed of 12 sequenced human gut bacterial species were fed oscillating diets of disparate composition. Rapid, reproducible and reversible changes in community structure were observed. Time series microbial RNA-Seq analyses revealed staggered functional responses to diet shifts throughout the community that were heavily focused on carbohydrate and amino acid metabolism. High-resolution shotgun metaproteomics confirmed many of these responses at a protein level. One member, Bacteroides cellulosilyticus WH2, proved exceptionally fit regardless of diet. Its genome encoded more carbohydrate active enzymes than any known Bacteroidetes. Transcriptional profiling indicated that B. cellulosilyticus WH2 is an adaptive forager that tailors its versatile carbohydrate utilization strategy to available dietary polysaccharides, with a strong emphasis on plant-derived xylans abundant in dietary staples like cereal grains. Two highly expressed, diet-specific polysaccharide utilization loci (PULs) in B. cellulosilyticus WH2 were identified, one with characteristics of xylan utilization systems. Introduction of a B. cellulosilyticus WH2 library comprising 26,750 isogenic transposon mutants into gnotobiotic mice along with other model community members confirmed that these loci represent critical diet-specific fitness determinants. The specific carbohydrates that trigger overexpression of these two loci and many of the organism's 111 other predicted PULs were identified by RNA-Seq during in vitro growth on 31 distinct carbohydrate substrates, allowing us to better interpret in vivo RNA-Seq and proteomics data. These results offer insight into how gut microbes adapt to dietary perturbations, both at a community level and from the perspective of a well-adapted symbiont with exceptional saccharolytic capabilities, and illustrate the value of studying defined models of the human gut microbiota.
The supplement material of 'Could land abandonment with human intervention benefit cropland restoration? From the perspective of soil microbiota'
<p>Figure S1 The study area and experimental plots. Figure S2 The correlation analysis of soil properties in each year, based on Spearman’s Rank correlation analysis. Only significant Spearman’s coefficients are shown (p < 0.05). Figure S3 Mantel test between soil properties and microbial community structure. *, ** and *** are used to show statistical significance at the 0.05, 0.01, and 0.001 level, respectively. Figure S4 The results of linear discriminant analysis effect size (LEfSe) on bacterial and fungal communities. The cutoff of LDA score is 2. Figure S5 The relative importance ranks of edaphic and human factors on microbial communities, based on %IncMSE of random forests model.</p>
Study of Human Microbiota in Healthy and Pathological Conditions
ClinicalTrials.gov study NCT03460392. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Human Milk Oligosaccharides' Impact on Maturation of the Gut Microbiota
ClinicalTrials.gov study NCT07026526. IPD Sharing: NO. Countries: 1. Publications: 0.
Oral and Gut Microbiota Changes During Long-term Fasting in Humans
ClinicalTrials.gov study NCT05449249. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Barley Green on Visceral Fat Area in the Human Body and Investigation Into the Associated Mechanism of Intestinal Microbiota
ClinicalTrials.gov study NCT06886048. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
ClinicalTrials.gov study NCT06133530. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Diet Interactions With Human Gut Microbiota. The Potential Role of Mediterranean Diet Adherence. DIAGRAM, a Pilot Study
ClinicalTrials.gov study NCT03080532. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Metagenomic Analysis of Human Gut Microbiota in Patients With Metabolic Diseases Including Diabetes
ClinicalTrials.gov study NCT03204799. IPD Sharing: NO. Countries: 1. Publications: 0.
Elucidating the Role of Human Small Intestine Microbiota in Explaining Differences in Postprandial Glucose Responses
ClinicalTrials.gov study NCT05120661. IPD Sharing: NO. Countries: 1. Publications: 0.
Vaginal Microbiota and Its Association with Pap Smear Results, Human Papillomavirus, Vitamins, and Metabolic Mark
ClinicalTrials.gov study NCT06897800. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of Human Microbiota Transplantation for Overweight and Obese Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT05253768. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effects of Sleep on Human Microbiota: Implications for Health and Disease
ClinicalTrials.gov study NCT02573753. IPD Sharing: NO. Countries: 1. Publications: 0.
Implications of the Human Microbiota for Health and Disease
ClinicalTrials.gov study NCT04203303. IPD Sharing: NO. Countries: 1. Publications: 0.
Sampling of Human Microbiota in Order to Test, on a Mouse Model, Individualized Intervention Strategies During Aging
ClinicalTrials.gov study NCT04753580. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.