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324
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ShareScore release 0.9.0
Dataset results
324 results for “humor”
Male and female genotype and a genotype-by-genotype interaction mediate the effects of mating on cellular but not humoral immunity in female decorated crickets
<p>Sexually antagonistic coevolution is predicted to lead to the divergence of male and female genotypes related to the effects of substances transferred by males at mating on female physiology. The outcome of mating should thus depend on the specific combination of mating genotypes. Although mating has been shown to influence female immunity in diverse insect taxa, a male-female genotype-by-genotype effect on female immunity post-mating remains largely unexplored. Here, we investigate the effects of mating on female decorated cricket baseline immunity and the potential for a male-by-female genotype interaction affecting this response. Females from three distinct genotypic backgrounds were left unmated or singly mated in a fully reciprocal design to males from the same three genotypic backgrounds. Hemocytes and hemocyte microaggregations were quantified for female cellular immunity, and phenoloxidase, involved in melanization, and antibacterial activity for humoral immunity. In this system, female cellular immunity was more reactive to mating, and mating effects were genotype dependent. Specifically, for hemocytes, a genotype-mating status interaction mediated the effect of mating per se, and a significant male-female genotype-by-genotype interaction determined hemocyte depletion post-mating. Microaggregations were influenced by the female's genotype or that of her mate. Female humoral immune measures were unaffected, indicating the propensity for post-mating effects on female is dependent on the component of baseline immunity. The genotype-by-genotype effect on hemocytes supports a role of sexual conflict in post-mating immune suppression, suggesting divergence of male genotypes with respect to modification of female post-mating immunity, and divergence of female genotypes in resistance to these effects.</p>
Human genomics of the humoral immune response against polyomaviruses
<p>Meta-analyses results of the manuscript "Human genomics of the humoral immune response against polyomaviruses".</p>
Amino acid variation in HLA class II proteins is a major determinant of humoral response to common viruses - GWAS summary results
<p>Online Supplementary Dataset of the manuscript "Amino acid variation in HLA class II proteins is a major determinant of humoral response to common viruses": http://www.cell.com/ajhg/fulltext/S0002-9297(15)00372-9</p>
Humoral immunity of voles Cricetidae Rodentia in Siberia
<p><span>We studied the seasonal variation of adaptive humoral immunity (AHI) in northern red-backed vole (<em>Clethrionomys rutilus</em> Pallas, 1779, RBV) and grey-sided vole (<em>C. rufocanus</em></span> <span>Sundevall, 1846, GSV) in Tomsk region of Western Siberia. Immunoresponsiveness (IR) to sheep red blood cells was assessed by the number of antibody-producing cells in the spleen. The use of a generalized linear model to analyze the effects of species, sex, year of research, and season of withdrawal of individuals from nature on IR showed a significant effect of species identity, season of animals capture and the interaction of species with season. The RBV demonstrated higher immune responses during a year, and both species had higher IR in winter. Suppression of IR in spring was greater, started earlier and lasted longer (March–May) in GSV. In RBV, immunosuppression was restricted to April. The significant negative within year correlations of IR with body mass and masses of reproductive organs in GSV a tradeoff between AHI and growth and reproduction processes. A reason for the difference between species in the seasonal variation of AHI may be related to the difference in tropho-energetic requirements of each vole species. GSV is a predominantly herbivorous rodent and its thermoregulation seems less efficient than of RBV. The deeper spring immunosuppression in GSV may explain in part its higher mortality during the season of colds.</span></p>
Discount Framed Humorous Advertisement
<p>It is the supplementary dataset for research titled as</p> <p>"Discount Framed Humorous Advertisement: An Exploratory Empirical Study"</p>
Exploration of humor in generative AI
<p>Twelve conversations with different open-source LLM-based chatbots (Cohere4AI, Gemma, Llama, Mistral) exploring humor understanding and production with zero-shot and n-shot strategies. Conversations were conducted via HuggingFace chat in Spring 2024, exported as HTML pages and bundled in a zip file.</p>
Assessment of the Humoral Immune Response to the SARS-CoV-2 Spike Protein Receptor Binding Motif
<p><strong>Figure S1.</strong> Purification of human antibodies against the RBM region of the SARS-CoV-2 spike protein using a recombinant RBM Sepharose 4B affinity column (3 x 1 cm, inner diameter) (A) and SDS-PAGE (10%) analysis of the eluate (1) alongside a standard low molecular weight marker (Sigma Chemical Co, Saint Louis, Mo, U.S.A.) stained with Coomassie Blue. <strong>Table S1</strong>: Microscale thermophoresis (MST) traces of anti-RBM antibodies binding to different concentrations of S1WT (red) and S2WT (green) peptides by MST. Relative fluorescence (RF) between the bound and unbound state was determined over a time of 21s with 20s MST-on time for evaluation. The blue bar indicates the ΔRF before the temperature gradient was applied, whereas the red bar shows the ΔRF during the thermophoresis. For interaction experi ments, the amount of NT.647-labeled antibodies was kept constant, while the concentration of unlabeled peptides varied from 0.5 µg/mL–0.12 ng/mL. The assay was performed in PBS containing 0.05% Tween 20 and after a short incubation period, the samples were analyzed in standard glass MST NT.115 capillaries. <strong>Table S2:</strong> One-dose regime AstraZeneca-Oxford vaccinated serum information. <strong>Table S3</strong>: Heterologous booster dose vaccinated serum information.</p>
Underlying dataset for the manuscript titled "Identification of RTS,S/AS01 vaccine-induced humoral biomarkers predictive of protection against controlled human malaria infection"
<p><span>The antibody binding data included in this dataset is associated with the manuscript “Spreng, R.L., Seaton, K.E. et al., <em><span>Identification of RTS,S/AS01 vaccine-induced humoral biomarkers predictive of protection against controlled human malaria infection; </span></em><span>Accepted for Publication in JCI Insight (2024)</span>. These data come from the characterization of serum samples from four controlled human malaria infection (CHMI) clinical trials of the RTS,S vaccine, including NCT01366534 (referred to as MAL068), NCT01857869 (referred to as MAL071), NCT03162614 (referred to as MAL092), and NCT03824236 (referred to as MAL102).</span></p>
Aqueous Humor Dynamics and Hypertensive Uveitis
ClinicalTrials.gov study NCT02765308. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of Cytokine Profiles in Aqueous Humor of Patients With Age Related Macular Degeneration (AMD)
ClinicalTrials.gov study NCT03418220. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Monovalent Oral Poliovirus Vaccine Type 1 Intestinal and Humoral Immunity Study
ClinicalTrials.gov study NCT03722004. IPD Sharing: NO. Countries: 1. Publications: 1.
Hepatitis C Virus and the Humoral Immune System
ClinicalTrials.gov study NCT00219999. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Use of Humor With Young Adults in Psychiatric Care
ClinicalTrials.gov study NCT04778163. IPD Sharing: NO. Countries: 1. Publications: 12.
Undetectable IgE as a Sentinel Biomarker for Humoral Immunodeficiency
ClinicalTrials.gov study NCT03968211. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of Intraocular Concentrations (Aqueous Humor, Vitreous Humor) of Antibiotics After Local and/or Systemic Administration in Endophthalmitis
ClinicalTrials.gov study NCT03968341. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance
ClinicalTrials.gov study NCT04412096. IPD Sharing: NO. Countries: 1. Publications: 2.
Monocytic Expression of Heme Oxidase-1 (HO-1) in Sickle Cell Patients and Correlation With the Humoral Immune Response to Vaccine and With Allo-immunization.
ClinicalTrials.gov study NCT03111589. IPD Sharing: NO. Countries: 1. Publications: 13.
The Evaluation of Cellular and Humoral Immunity to COVID-19 in Moscow Residents
ClinicalTrials.gov study NCT04898140. IPD Sharing: NO. Countries: 1. Publications: 2.
PTX-COVID19-B, an mRNA Humoral Vaccine, is Intended for Prevention of COVID-19 in a General Population. This Study is Designed to Evaluate Safety, Tolerability, and Immunogenicity of PTX-COVID19-B Vac
ClinicalTrials.gov study NCT04765436. IPD Sharing: NO. Countries: 1. Publications: 1.
Humoral and Cellular İmmune Response to SARS-CoV-2 mRNA BNT162b2 Vaccine in Children With Chronic Kidney Diseases
ClinicalTrials.gov study NCT05465863. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.