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167
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Dataset results
167 results for “immunomodulation;”
StuA-Regulated Processes in the Dermatophyte T. rubrum: Transcription Profile, Cell-Cell Adhesion, and Immunomodulation
GEO Series GSE163357. Trichophyton rubrum. 18 samples. Type: Expression profiling by high throughput sequencing.
Inducing bacterial calcification for systematic treatment and immunomodulation against Methicillin-resistant Staphylococcus aureus
GEO Series GSE298599. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Eradication of donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance their therapeutic values.
GEO Series GSE165811. Homo sapiens. 50 samples. Type: Expression profiling by high throughput sequencing.
Neoadjuvant-induced Complement Upregulation in Tumor Microenvironment is Associated with Immunomodulation and Improved Survival in Pancreatic Ductal Adenocarcinoma: Insights from Spatially Resolved Tr
GEO Series GSE240078. Homo sapiens. 242 samples. Type: Other.
The extracellular interactome of the human Adenovirus family reveals diverse strategies for immunomodulation
GEO Series GSE78518. Homo sapiens; Human mastadenovirus A. 96 samples. Type: Protein profiling by protein array.
Dose-dependent immunomodulation of human dendritic cells by the probiotic Lactobacillus rhamnosus Lcr35
GEO Series GSE25699. Homo sapiens. 2 samples. Type: Expression profiling by array.
Microneedle-mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune-Mediated Alopecia
GEO Series GSE267295. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Umbilical cord as a long-term source of activatable MSC for immunomodulation
GEO Series GSE117901. Homo sapiens. 21 samples. Type: Expression profiling by array.
Functional polymer-dependent 3D culture enhances the immunomodulating potential of human bone marrow mesenchymal stromal cells
GEO Series GSE236113. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Protection against maternal infection-associated fetal growth restriction: proof-of-concept with a microbial-derived immunomodulator
GEO Series GSE85414. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation
GEO Series GSE39785. Mus musculus. 16 samples. Type: Expression profiling by array.
Biological Effects of Intraoperative Radiation Therapy (IORT): Histopathological Changes and Immunomodulation in Breast Cancer Patients
GEO Series GSE253650. Homo sapiens. 37 samples. Type: Expression profiling by high throughput sequencing.
Chimeric exosomes-derived immunomodulator restoring lymph node microenvironment for sensitizing TNBC immunotherapy
GEO Series GSE270025. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
The impact of Lactobacillus plantarum sortase on target-protein sorting, gastrointestinal persistence and host immunomodulation
GEO Series GSE34999. Lactiplantibacillus plantarum. 8 samples. Type: Expression profiling by array.
Rapamycin Immunomodulation Utilizes Time-Dependent Alterations of Lymph Node Architecture, Leukocyte Trafficking, and Gut Microbiome
GEO Series GSE288851. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration
GEO Series GSE226780. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A Novel Gene Regulates Vesiculogenesis and Immunomodulation in Mycobacterium tuberculosis
GEO Series GSE50050. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients
<p><strong>Background: </strong>Imatinib reduced 90-day mortality in hospitalised coronavirus disease 2019 (COVID-19) patients in a recent clinical trial, but the biological effects that cause improved clinical outcomes are unknown. We aimed to determine the biological changes elicited by imatinib in patients with COVID-19 and what baseline biological profile moderates the effect of imatinib.</p> <p><strong>Methods:</strong> We undertook a secondary analysis of a randomised, double-blind, placebo-controlled trial of oral imatinib in hospitalised, hypoxaemic COVID-19 patients. Mediating effects of changes in plasma concentration of 25 plasma host response biomarkers on the association between randomisation group and 90-day mortality were studied by combining linear mixed effect modelling and joint modelling. Moderation of baseline biomarker concentrations was evaluated by Cox regression modelling. We identified subphenotypes using Ward’s method clustering and evaluated moderation of these subphenotypes using the aforementioned method.</p> <p><strong>Results:</strong> 332 out of 385 participants had plasma samples available. Imatinib increased the concentration of surfactant protein D (SP-D), and decreased the concentration of interleukin-6, procalcitonin, angiopoietin (Ang)-2/Ang-1 ratio, E-selectin, tumour necrosis factor (TNF)-α, and TNF receptor I. The effect of imatinib on 90-day mortality was fully mediated by changes in these biomarkers. Cluster analysis revealed three host response subphenotypes. Mortality benefit of imatinib was only present in the subphenotype characterised by alveolar epithelial injury indicated by increased SP-D levels in the context of systemic inflammation and endothelial dysfunction (hazard ratio 0.30, 95% CI 0.10–0.92).</p> <p><strong>Conclusions: </strong>The effect of imatinib on mortality in hospitalised COVID-19 patients is mediated through modulation of innate immune responses and reversal of endothelial dysfunction, and possibly moderated by biological subphenotypes.</p>
Immunomodulation of E.Coli Nissle 1917 in Patients With Grass Pollen Rhinoconjunctivitis
ClinicalTrials.gov study NCT01013259. IPD Sharing: Not stated. Countries: 1. Publications: 0.
GM-CSF for Immunomodulation Following Trauma (GIFT) Study
ClinicalTrials.gov study NCT01495637. IPD Sharing: YES. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.