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Dataset results
109 results for “in vivo imaging”
Research data supporting "In Vivo Biomolecular Imaging of Zebrafish Embryos using Confocal Raman Spectroscopy"
<p>Research raw data supporting Hogset et al., "In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy", 2020, Nature Communications.</p>
Data from: In-vivo imaging of cell migration using contrast enhanced MRI and SVM based post-processing
The migration of cells within a living organism can be observed with magnetic resonance imaging (MRI) in combination with iron oxide nanoparticles as an intracellular contrast agent. This method, however, suffers from low sensitivity and specificty. Here, we developed a quantitative non-invasive in-vivo cell localization method using contrast enhanced multiparametric MRI and support vector machines (SVM) based post-processing. Imaging phantoms consisting of agarose with compartments containing different concentrations of cancer cells labeled with iron oxide nanoparticles were used to train and evaluate the SVM for cell localization. From the magnitude and phase data acquired with a series of -weighted gradient-echo scans at different echo-times, we extracted features that are characteristic for the presence of superparamagnetic nanoparticles, in particular hyper- and hypointensities, relaxation rates, short-range phase perturbations, and perturbation dynamics. High detection quality was achieved by SVM analysis of the multiparametric feature-space. The in-vivo applicability was validated in animal studies. The SVM detected the presence of iron oxide nanoparticles in the imaging phantoms with high specificity and sensitivity with a detection limit of 30 labeled cells per mm3, corresponding to 19 μM of iron oxide. As proof-of-concept, we applied the method to follow the migration of labeled cancer cells injected in rats. The combination of iron oxide labeled cells, multiparametric MRI and a SVM based post processing provides high spatial resolution, specificity, and sensitivity, and is therefore suitable for non-invasive in-vivo cell detection and cell migration studies over prolonged time periods.
Data from: High-throughput synapse-resolving two-photon fluorescence microendoscopy for deep-brain volumetric imaging in vivo
Optical imaging has become a powerful tool for studying brains in vivo. The opacity of adult brains makes microendoscopy, with an optical probe such as a gradient index (GRIN) lens embedded into brain tissue to provide optical relay, the method of choice for imaging neurons and neural activity in deeply buried brain structures. Incorporating a Bessel focus scanning module into two-photon fluorescence microendoscopy, we extended the excitation focus axially and improved its lateral resolution. Scanning the Bessel focus in 2D, we imaged volumes of neurons at high-throughput while resolving fine structures such as synaptic terminals. We applied this approach to the volumetric anatomical imaging of dendritic spines and axonal boutons in the mouse hippocampus, and functional imaging of GABAergic neurons in the mouse lateral hypothalamus in vivo.
Raw MRI imaging for "In Vivo Neuroprotection in Ischemic Stroke by Activated Protein C Requires β-Arrestin 2"
<p><span>The protease, activated protein C (APC) and its variants provide pharmacological benefits in many murine preclinical injury models, including neuroprotection for ischemic stroke and mortality reduction for sepsis.<span> </span>The <em>in vivo</em> mechanism of action for APC in ischemic stroke and sepsis injury models, similar to extensive in vitro studies using cultured cells, involves protease activated receptor (PAR) 1-mediated biased signaling. Cell culture studies showed that APC/PAR1 signaling requires β-Arrestin 2, an intracellular scaffold protein, and that β-Arrestin 2-dependent, APC-initiated signaling can distinctly alter a wide variety of intracellular signaling pathways.<span> </span>It is unclear whether <em>in vitro</em> studies can be extrapolated to <em>in vivo</em> mechanisms of action.<span> </span>This study employed a proximal transient Middle Cerebral Artery Occlusion model to study the neuroprotective actions of the signaling-selective APC variant, 3K3A-APC, in β-arrestin 2 deficient (<em>Arrb2</em><sup>-/-</sup>) mice. Based on the size and shape of brain injury areas, 3K3A-APC significantly limited brain injury in control mice to a relatively small, localized area whereas these protective effects were lost in <em>Arrb2<sup>-/-</sup></em> mice. Thus, these data indicate that the major <em>in vitro</em> mechanism of action that requires β-arrestin 2 for APC/PAR1 biased signaling is central to the <em>in vivo</em> mechanism of action for APC’s neuroprotection. </span></p>
FAPi-PET Imaging of in Vivo Fibrosis in Inflammatory Bowel Disease Patients
ClinicalTrials.gov study NCT06604260. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Effect of Using Image Standardization Device for Dental Photography Standerdizatuon in Comparison to Individualized Photography In Vivo Study
ClinicalTrials.gov study NCT04991363. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
In Vivo Molecular Imaging Predicts Therapeutic Response in Ulcerative Colitis
ClinicalTrials.gov study NCT02852850. IPD Sharing: Not stated. Countries: 1. Publications: 0.
In Vivo Cross-Modal Imaging of Skin
ClinicalTrials.gov study NCT07188948. IPD Sharing: NO. Countries: 1. Publications: 0.
Benchmarking Intra-tumor Heterogeneity In Ovarian Cancer: Linking In-vivo Imaging Phenotypes With Histology And Genomics
ClinicalTrials.gov study NCT02144311. IPD Sharing: Not stated. Countries: 1. Publications: 0.
In-vivo Optical Coherence Tomography Imaging in Dermatooncology
ClinicalTrials.gov study NCT01680562. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of an Integrated Imaging System For In Vivo Detection of Fluorescently Labeled Lesions
ClinicalTrials.gov study NCT02802553. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An in Vivo CT Imaging Study of GMA-Tulip, I-gel, and LMA Supreme (GLAM-II)
ClinicalTrials.gov study NCT07196696. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pilot Study Utilising an Impression Technique to Capture in Vivo Images of Teeth
ClinicalTrials.gov study NCT02676219. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Integrated Imaging System for In Vivo Visualization of Free Flap Perfusion Using Indocyanine Dye
ClinicalTrials.gov study NCT03625765. IPD Sharing: Not stated. Countries: 1. Publications: 0.
NIR Hypoxia Imaging of Breast Tumor Response to Neoadjuvant Chemotherapy in Vivo
ClinicalTrials.gov study NCT01934114. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of the Heidelberg Engineering SPECTRALIS With Flex Module for In-vivo Imaging in the Supine Position
ClinicalTrials.gov study NCT04661124. IPD Sharing: NO. Countries: 1. Publications: 0.
In Vivo Evaluation of Image Registration Techniques During Endovascular Repair
ClinicalTrials.gov study NCT03116880. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Ex Vivo Tumor Visualization and Resection Margin Assessment Using Topically Applied Fluorescent Imaging Agents
ClinicalTrials.gov study NCT06292845. IPD Sharing: YES. Countries: 1. Publications: 0.
Assessment of in Vivo Skeletal Muscle Viscoelasticity (ARFI Imaging) With Aging and Cancer
ClinicalTrials.gov study NCT01484821. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CAR-T Cell Therapy in RelApsed/Refractory Myeloma With ExtrameduLlary Disease - an in Vivo Imaging and Molecular Monitoring Study
ClinicalTrials.gov study NCT05666700. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.