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Dataset results
1,337 results for “inflammatory disease”
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease
<p>***<strong>These data supersede the previous release. Please disregard data uploaded prior to October 30th as the metadata was incorrect - note the correct data in Supplementary Table 1</strong>***</p> <p>A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease. </p> <p>GEO ID for bam files and CellRanger pipeline output (filtered and unfiltered): <strong>GSE282122</strong></p> <p>TAURUS_raw_counts_annotated_final.h5ad: This file is the pooled data across all cell types</p> <p>UMAP_combined_objects.txt.gz: This file has the corresponding UMAP for pooled data</p> <p>PC_combined_objects.txt.gz: This file has the corresponding PC for pooled data</p> <p>paired_sample_list.csv: This file has the paired samples used in analysis for baseline/longitudinal analysis. For baseline analyses, please use baseline samples > 6.5 inflammation score to recapitulate the analyses in the paper.</p> <p>Other data to be uploaded to Zenodo include H&E slides. Please access interactive MDV browser here.</p>
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
<p>This directory contains custom codes and supplementary datasets generated for the study "Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases".<br> </p>
Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition
<p><strong>Objectives</strong> How the local inflammatory environment regulates epigenetic changes in the context of inflammatory arthritis remains unclear. Here we assessed the transcriptional and active enhancer profile of monocytes derived from the inflamed joints of Juvenile Idiopathic Arthritis (JIA) patients, a model well-suited for studying inflammatory arthritis.<br> <strong>Methods </strong>RNA-sequencing and H3K27me3 chromatin immunoprecipitation sequencing (ChIP-seq) were used to analyze the transcriptional and epigenetic profile, respectively, of JIA synovial fluid-derived monocytes.<br> <strong>Results </strong>Synovial-derived monocytes display an activated phenotype, which is regulated on the epigenetic level. IFN signaling-associated genes are increased and epigenetically altered in synovial monocytes, indicating a driving role for IFN in establishing the local inflammatory phenotype. Treatment of synovial monocytes with the Janus-associated kinase (JAK) inhibitor ruxolitinib, which inhibits IFN signaling, transformed the activated enhancer landscape and reduced disease-associated gene expression, thereby inhibiting the inflammatory phenotype.<br> <strong>Conclusion </strong>This study provides novel insights into epigenetic regulation of inflammatory arthritis patient-derived monocytes and highlights the therapeutic potential of epigenetic modulation for the treatment of inflammatory rheumatic diseases.</p> <p><br> <strong>Data deposited</strong></p> <ul> <li>H3K27ac ChIP-seq peak coordinates of healthy control peripheral blood-derived monocytes and JIA peripheral blood- and synovial fluid-derived monocytes (Figure 2 in article).</li> <li>Individual and merged peak coordinates of H3K27ac and H3K4me1 ChIP-seq on JIA monocytes with and without Ruxolitinib and IFN gamma (Figure 4 in article).</li> <li>Gene expression data of JIA monocytes treated with and without JQ1 (Figure 2 in article).</li> <li>Gene expression data of Ruxolitinib- and IFN-stimulated JIA monocytes (Figure 5 in article).</li> </ul>
Infliximab Infusion Rates in Pediatric Inflammatory Bowel Disease
ClinicalTrials.gov study NCT06839820. IPD Sharing: NO. Countries: 1. Publications: 6.
A Development of Inflammatory Bowel Disease Pattern Identification Algorithm Using Case Series Data
ClinicalTrials.gov study NCT04296500. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Inflammatory Bowel Disease in South Eastern Norway
ClinicalTrials.gov study NCT02727959. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Trial to Determine the Effects of Exercise in Inflammatory Bowel Disease and Rheumatoid Arthritis
ClinicalTrials.gov study NCT02463916. IPD Sharing: Not stated. Countries: 1. Publications: 10.
The Effect of Intestinal Microbiota Transplantation for Inflammatory Bowel Diseases
ClinicalTrials.gov study NCT03426683. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
A Study Investigating the Safety, Absorption and Elimination of GLPG3312, a New Drug in the Treatment of Inflammatory Diseases
ClinicalTrials.gov study NCT03800472. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Chronic Inflammatory Disease, Lifestyle and Treatment Response
ClinicalTrials.gov study NCT03173144. IPD Sharing: YES. Countries: 1. Publications: 4.
Sick Leave, Work Disability and Quality of Life in Korean Patients With Inflammatory Bowel Diseases
ClinicalTrials.gov study NCT03565432. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Interest of GLP1 Analogues in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease
ClinicalTrials.gov study NCT05196958. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Development and Validation of a Self-reported Objective Index of Work Disability in Inflammatory Bowel Disease
ClinicalTrials.gov study NCT03872726. IPD Sharing: NO. Countries: 1. Publications: 7.
De-escalation of Anti-TNF Therapy in Inflammatory Bowel Disease
ClinicalTrials.gov study NCT04646187. IPD Sharing: NO. Countries: 3. Publications: 1.
A Pilot Study of Inflammatory Markers in Alzheimer's Disease
ClinicalTrials.gov study NCT00715858. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Comparison Between the Biomarkers in Inflammatory Bowel Disease Patients and General Control Group
ClinicalTrials.gov study NCT03778918. IPD Sharing: NO. Countries: 1. Publications: 3.
Effect of a Probiotic Mixture on the Gut Microbiome and Fatigue in Patients With Quiescent Inflammatory Bowel Disease
ClinicalTrials.gov study NCT03266484. IPD Sharing: NO. Countries: 1. Publications: 0.
Diet / Gut Microbiome Interaction and Influence on Inflammatory Disease in HIV Patients
ClinicalTrials.gov study NCT02610374. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparing Effectiveness of Steroids and Methotrexate in Treatment of Chronic Inflammatory Breast Disease
ClinicalTrials.gov study NCT06943482. IPD Sharing: NO. Countries: 1. Publications: 8.
Telephone Consultation as a Substitute for Routine Out-patient Face-to-face Consultation for Children With Inflammatory Bowel Disease
ClinicalTrials.gov study NCT02319798. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.