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opencc-zeroMay 2023View details →

Data from: Developmental rate displays effects of inheritance but not of sex in interpopulation hybrids of Tigriopus californicus

Coevolved genetic interactions within populations can be disrupted by hybridization resulting in loss of fitness in hybrid individuals (i.e., hybrid breakdown). However, the extent to which variation in fitness-related traits among hybrids is inherited across generations remains unclear, and variation in these traits may be sex-specific in hybrids due to differential effects of genetic incompatibilities in females and males. Here we present two experiments investigating variation in developmental rate among reciprocal inter-population hybrids of the intertidal copepod Tigriopus californicus. Developmental rate is a fitness-related trait in this species that is affected by interactions between mitochondrial-encoded and nuclear-encoded genes in hybrids that result in variation in mitochondrial ATP synthesis capacities. First, we show that F2-hybrid developmental rate is equivalent in two reciprocal crosses and is unaffected by sex, suggesting that breakdown of developmental rate is likely experienced equally by females and males. Second, we demonstrate that variation in developmental rate among F3 hybrids is heritable; times to copepodid metamorphosis of F4 offspring of fast-developing F3 parents (12.25 ± 0.05 d, μ ± SEM) were significantly faster than those of F4 offspring of slow-developing parents (14.58 ± 0.05 d). Third, we find that ATP synthesis rates in these F4 hybrids are unaffected by the developmental rates of their parents, but that mitochondria from females synthesize ATP at faster rates than mitochondria from males. Taken together, these results suggest that sex-specific effects vary among fitness-related traits in these hybrids and that effects likely associated with hybrid breakdown display substantial inheritance across hybrid generations.

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Multiple paternally inherited chloroplast capture events associated with Taxus speciation in the Hengduan Mountains

Template files and estimation files in Fastsimcoal2 for 16 models. Each model corresponded with the same name in Fig S2 and Fig S3. And SNP file, plastome matrix and transcriptome matrixes

opencc-by-4.0Jul 2023View details →

opencc-zeroOct 2023View details →

Vertically inherited microbiota and environment-modifying behaviors indirectly shape the exaggeration of secondary sexual traits in the gazelle dung beetle

Many organisms actively manipulate the environment in ways that have the potential to feed back on their own development, a process referred to as developmental niche construction. Yet, the role that constructed biotic and abiotic environments play in shaping phenotypic variation and its evolution is insufficiently understood. Here, we assess whether environmental modifications made by developing dung beetles impact the environment-sensitive expression of secondary sexual traits. Larval gazelle dung beetles both physically modify their ontogenetic environment and structure their biotic interactions through the vertical inheritance of microbial symbionts. By experimentally eliminating i) physical environmental modifications, and ii) the vertical inheritance of microbes, we assess the degree to which (sym)biotic and physical environmental modifications shape the exaggeration of several traits varying in their degree and direction of sexual dimorphism. We expected the experimental reduction of a larva's ability to shape its environment to affect trait size and scaling, especially for traits that are sexually dimorphic and environmentally plastic. We find that compromised developmental niche construction indeed shapes sexual dimorphism in overall body size and the absolute sizes of male-limited exaggerated head horns, the strongly sexually dimorphic fore tibia length and width, as well as the weakly dimorphic elytron length and width. This suggests that ontogenetic environmental modifications affect sex-specific phenotypic variation in functional traits. However, most of these effects can be attributed to nutrition-dependent plasticity in size and non-isometric trait scaling, rather than body-size-independent effects on the developmental regulation of trait size. Our findings suggest that the reciprocal relationship between developing organisms, their symbionts, and their environment can have considerable impacts on sexual dimorphism and functional morphology.

Evaluation of Recombinant Factor XIII for Prevention of Bleeding in Patients With FXIII Inherited Deficiency

ClinicalTrials.gov study NCT00713648. IPD Sharing: Not stated. Countries: 11. Publications: 2.

A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease

ClinicalTrials.gov study NCT02473445. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's

ClinicalTrials.gov study NCT04623242. IPD Sharing: YES. Countries: 8. Publications: 13.

Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders

ClinicalTrials.gov study NCT07083583. IPD Sharing: YES. Countries: 1. Publications: 9.

An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 (Tofersen) in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS)

ClinicalTrials.gov study NCT02623699. IPD Sharing: YES. Countries: 12. Publications: 3.

Evaluation Of The Efficacy And Safety Of Single Doses Of PF-05089771 In Patients With Primary (Inherited) Erythromelalgia

ClinicalTrials.gov study NCT01769274. IPD Sharing: YES. Countries: 1. Publications: 1.

A Study of the Use of Factor XIII Concentrate in Patients With Inherited FXIII Deficiency

ClinicalTrials.gov study NCT00883090. IPD Sharing: Not stated. Countries: 2. Publications: 1.

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's

ClinicalTrials.gov study NCT06424236. IPD Sharing: YES. Countries: 6. Publications: 13.

HSCT for High Risk Inherited Inborn Errors

ClinicalTrials.gov study NCT00383448. IPD Sharing: Not stated. Countries: 1. Publications: 1.

Targeting the IPA and Matching for the Non-Inherited Maternal Antigen for Haplo-Cord Transplantation

ClinicalTrials.gov study NCT01810588. IPD Sharing: Not stated. Countries: 1. Publications: 2.

Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)

ClinicalTrials.gov study NCT02624869. IPD Sharing: YES. Countries: 23. Publications: 3.

A Study to Assess Safety and Target Engagement of E2814 in Participants With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease

ClinicalTrials.gov study NCT04971733. IPD Sharing: YES. Countries: 2. Publications: 0.

publicFeb 2025View details →

EBAX-1/ZSWIM8 destabilizes miRNAs resulting in transgenerational inheritance of a predatory trait

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publicJul 2025View details →

Migratory routes are inherited primarily from mother in a terrestrial herbivore

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