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968
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Dataset results
968 results for “lung diseases”
A Follow-up Study Investigating Long Term Treatment With Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD)
ClinicalTrials.gov study NCT03820726. IPD Sharing: YES. Countries: 15. Publications: 1.
The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT02252588. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Physical Activity and Quality of Life in Fibrotic Lung Diseases After Initiating Anti-fibrotic Therapy and Pulmonary Rehabilitation
ClinicalTrials.gov study NCT05866198. IPD Sharing: NO. Countries: 1. Publications: 4.
Lung proteome and metabolome endotype in HIV-associated obstructive lung disease
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Data from: Association of chronic obstructive pulmonary disease with risk of lung cancer in individuals aged 40 years and older: A cross-sectional study based on NHANES 2013-2018
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Neutrophil extracellular traps are present in the airways of ENaC-overexpressing mice with cystic fibrosis-like lung disease
<p>Background: Neutrophils are key components of the exacerbated inflammation and tissue damage in cystic fibrosis (CF) airways. Neutrophil extracellular traps (NETs) trap and kill extracellular pathogens. While NETs are abundant in the airways of CF patients and have been hypothesized to contribute to lung damage in CF, the in vivo role of NETs remains controversial, partially due to lack of appropriate animal models. The goal of this study was to detect NETs and to further characterize neutrophilmediated inflammation in the airways of mice overexpressing the epithelial sodium channel (βENaC-Tg mice on C57BL/6 background) in their lung with CF-like airway disease, in the absence of any apparent bacterial infections.</p> <p>Methods: Histology scoring of lung tissues, flow cytometry, multiplex ELISA, immunohistochemistry and immunofluorescence were used to characterize NETs and the airway environment in uninfected, βENaC-Tg mice at 6 and 8 weeks of age, the most chronic time points so far studied in this model.</p> <p>Results: Excessive neutrophilic infiltration characterized the lungs of uninfected, βENaC-Tg mice at 6 and 8 weeks of age. The bronchoalveolar lavage fluid (BALF) of βENaC-Tg mice contains increased levels of CF-associated cytokines and chemokines: KC, MIP-1α/β, MCP-1, G-CSF, IL-5, and IL-6. The BALF of βENaC-Tg mice contain MPO-DNA complexes, indicative of the presence of NETs. Immunofluorescence and flow cytometry of BALF neutrophils and lung tissues demonstrated increased histone citrullination, a NET-specific marker, in βENaC-Tg mice.</p> <p>Conclusions: NETs are detected in the airways of βENaC-Tg mice, in the absence of bacterial infections. These data demonstrate the usefulness of the βENaC-Tg mouse to serve as a model for studying the role of NETs in chronic CF airway inflammation.</p> <p>Keywords Cystic fibrosis; neutrophil extracellular traps; NET; ENaC, neutrophil.</p>
Disease trajectories in hospitalized COVID-19 patients are predicted by clinical and peripheral blood signatures representing distinct lung pathologies
<p><span>COVID-19 is characterized by a broad range of symptoms and disease trajectories. Understanding the correlation between clinical biomarkers and lung pathology over the course of acute COVID-19 is necessary to understand its diverse pathogenesis and inform more precise and effective treatments. Here, we present an integrated analysis of longitudinal clinical parameters, peripheral blood biomarkers, and lung pathology in COVID-19 patients from the Brazilian Amazon. We identified core clinical and peripheral blood signatures differentiating disease progression between recovered patients from severe disease and fatal cases. Signatures were heterogenous among fatal cases yet clustered into two patient groups: “early death” (< 15 days of disease until death) and “late death” (> 15 days). Progression to early death was characterized systemically and in lung histopathology by rapid, intense endothelial and myeloid activation/chemoattraction and presence of thrombi, associated with SARS-CoV-2<sup>+</sup> macrophages. In contrast, progression to late death was associated with fibrosis, apoptosis and abundant SARS-CoV-2<sup>+</sup> epithelial cells in post-mortem lung, with cytotoxicity, interferon and Th17 signatures only detectable in the peripheral blood 2 weeks into hospitalization. Progression to recovery was associated with higher lymphocyte counts, Th2 and anti-inflammatory-mediated responses. By integrating ante-mortem longitudinal systemic and spatial single-cell lung signatures, we defined an enhanced set of prognostic clinical parameters predicting disease outcome for guiding more precise and optimal treatments.</span><span> Finally, this study represents a major advance in the investigation of acute respiratory infections by integrating serial clinical data and peripheral blood samples with histopathological and </span><span>spatially-resolved single-cell </span><span>analyses of post-mortem lung samples.</span></p>
Effect of emodin on lung inflammation and intestinal microbes in Chronic Obstructive Pulmonary Disease
<p><strong>Effect of emodin on lung inflammation and intestinal microbes in Chronic Obstructive Pulmonary Disease</strong></p>
Remote Monitoring of Interstitial Lung Disease
ClinicalTrials.gov study NCT04850521. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pursed Lip Breathing in Interstitial Lung Disease
ClinicalTrials.gov study NCT02934750. IPD Sharing: NO. Countries: 1. Publications: 1.
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Qifangfeixian Granules in the Treatment of Connective Tissue Disease-Associated Interstitial Lung Diseas
ClinicalTrials.gov study NCT06674148. IPD Sharing: NO. Countries: 1. Publications: 10.
The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease
ClinicalTrials.gov study NCT00974064. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study of the Efficacy of Nintedanib+Tocilizumab in Patients With Systemic Sclerosis and Interstitial Lung Disease
ClinicalTrials.gov study NCT06297096. IPD Sharing: NO. Countries: 1. Publications: 8.
The Study Of Probe-Based Confocal Laser Endomicroscopy Of Distal Airways In Diagnostics Of Lung Diseases
ClinicalTrials.gov study NCT02006940. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nasal High-flow Oxygen Therapy During Acute Exercise in Fibrotic Interstitial Lung Disease
ClinicalTrials.gov study NCT07129707. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Prevention of Chronic Lung Disease (CLD) in Preterm Infants
ClinicalTrials.gov study NCT00883532. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Mechanisms of Exertional Dyspnea in Fibrotic Interstitial Lung Disease
ClinicalTrials.gov study NCT01781793. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deployment-Related Lung Disease Research Database and Biorepository
ClinicalTrials.gov study NCT03035097. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Neuromuscular Electrical Stimulation in Patients With Interstitial Lung Disease
ClinicalTrials.gov study NCT02497144. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Scleroderma Lung Disease
ClinicalTrials.gov study NCT00004563. IPD Sharing: Not stated. Countries: 0. Publications: 14.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.