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Dataset results
237 results for “mechanism of action”
Mechanism of Action Trial of ColoAd1
ClinicalTrials.gov study NCT02053220. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Physiological Study to Assess Mechanism of Action of MOBIDERM® in Lower-limb Lymphedema Patients
ClinicalTrials.gov study NCT04252690. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Spa Therapy in Knee Osteoarthritis: Study on Cost/Effectiveness - Cost/Utility and Possible Mechanisms of Action
ClinicalTrials.gov study NCT01538043. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Ketamine's Actions on Rumination Mechanisms as an Antidepressant
ClinicalTrials.gov study NCT04656886. IPD Sharing: YES. Countries: 0. Publications: 4.
The Mechanism of Action of Chlormethine (CL) Gel in the Treatment of MF-CTCL Adult Patients
ClinicalTrials.gov study NCT06421571. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Elucidating the Central Mechanisms of Action for Green Light Therapy in Managing Chronic Pain
ClinicalTrials.gov study NCT05569486. IPD Sharing: NO. Countries: 1. Publications: 6.
Mechanisms of LPRF Action in the Promotion of Wound Healing and Tissue Regeneration
ClinicalTrials.gov study NCT03992638. IPD Sharing: UNDECIDED. Countries: 1. Publications: 33.
Alemtuzumab in Autoimmune Inflammatory Neurodegeneration: Mechanisms of Action and Neuroprotective Potential
ClinicalTrials.gov study NCT02419378. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.
ClinicalTrials.gov study NCT01232244. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigating Mechanism of Action of DAC HYP in the Treatment of High-Inflammatory Multiple Sclerosis (MS)
ClinicalTrials.gov study NCT01143441. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Safety, Tolerability And Mechanism Of Action Of Boswellic Acids (BA) In Multiple Sclerosis (SABA)
ClinicalTrials.gov study NCT01450124. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Teriparatide (Forsteo) Treatment in Postmenopausal Women: Mechanism of Action
ClinicalTrials.gov study NCT01293292. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigating the Efficacy of Low or High Dose Tart Cherry on Recovery From Exercise Induced Muscle Damage and Establishing Its Molecular Mechanisms of Action
ClinicalTrials.gov study NCT04725149. IPD Sharing: NO. Countries: 1. Publications: 0.
Understanding the Mechanism(s) of Action on the Modified Atkins Diet for Epilepsy: Human Brain Tissues
ClinicalTrials.gov study NCT02565966. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mechanism of Action of tACS for the Treatment of MDD
ClinicalTrials.gov study NCT03994081. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor.
Extracellular vesicles (EVs) are membrane enclosed nanostructures released by cells into the extracellular environment. As major actors of physiological intercellular communication, they have been shown to be pathogenic mediators of several liver diseases. EVs also appear to be potential actors of drug-induced liver injury, but nothing is known concerning environmental pollutants. We aimed to study the impact of polycyclic aromatic hydrocarbons (PAHs), major contaminants, on hepatocyte-derived EV production, with a special focus on hepatocyte death. Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Treatment of primary rat and WIF-B9 hepatocytes by all three PAHs increased the release of EVs, mainly comprised of exosomes, in parallel with modifying exosome protein marker expression and inducing apoptosis. Moreover, PAH treatment of rodents for three months also led to increased EV levels in plasma. The EV release involved CYP metabolism and the activation of the transcription factor, the AhR, for BP and DBA and another transcription factor, the constitutive androstane receptor (CAR), for PYR. Furthermore, all PAHs increased cholesterol levels in EVs but only BP and DBA were able to reduce the cholesterol content of total cell membranes. All cholesterol changes very likely participated in the increase in EV release and cell death. Finally, we studied changes in cell membrane fluidity caused by BP and DBA due to cholesterol depletion. Our data showed increased cell membrane fluidity, which contributed to hepatocyte EV release and cell death.
Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor
<p>Datasets to Stauffer et al. (2022) Commun. Chem. </p>
Fig. 1 in Mechanisms of action for the anti-obesogenic activities of phytochemicals
Fig. 1. Major causes of obesity and associated complications.
Fig. 2 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 2. Chemical structure of Astragalus polysaccharide (Liu et al., 2020).
Fig. 4 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 4. Astragalus spinosus (Alsirhan, 2002).
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.