Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
179
datasets available to search
ShareScore release 0.9.0
Dataset results
179 results for “metabolic disorder”
Integrated genomic, transcriptomic and metabolomic analysis reveals MDH2 mutation-induced metabolic disorder in recurrent focal segmental glomerulosclerosis
GEO Series GSE212610. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of HuR
GEO Series GSE103417. Mus musculus. 24 samples. Type: Expression profiling by array.
The Impact of TLR5 on Liver Function in Age-Related Metabolic Disorders
GEO Series GSE272622. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Nck2 Regulates Adiposity and Adiposity-Related Metabolic Disorders in Mice and Human
GEO Series GSE63510. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Intestinal stearoyl-CoA desaturase-inhibition improves obesity-associated metabolic disorders
GEO Series GSE272268. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
A central role for disordered renal metabolism in myotonic dystrophy type 1
GEO Series GSE284252. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Genitourinary defects, anxiety and aggressive-like behavior and glucose metabolism disorders in Zmym2 mutant mice with inserted piggyBac transposon
GEO Series GSE305505. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
GEO Series GSE97645. Mus musculus. 16 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Uncovering altered neural molecular mechanisms in metabolic disorders induced psychiatric disorders
GEO Series GSE272983. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Disordered maturation of mitochondrial matrix proteins in adipose tissue leads to local and systemic metabolic and inflammatory derangements in adipocyte-specific Mipep knockout mice
GEO Series GSE282147. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Data from: Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders by inducing a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp ⁄NDmcr rats
Increased energy intake and reduced physical activity can lead to obesity, diabetes and metabolic syndrome. Transcriptional modulation of metabolic networks has become a focus of current drug discovery research into the prevention and treatment of metabolic disorders associated with energy surplus and obesity. Tang-Nai-Kang (TNK), a mixture of five herbal plant extracts, has been shown to improve abnormal glucose metabolism in patients with pre-diabetes. Here, we report the metabolic phenotype of SHR.Cg-Leprcp/NDmcr (SHR/cp) rats treated with TNK. Pre-diabetic SHR/cp rats were randomly divided into control, TNK low-dose (1.67 g/kg) and TNK high-dose (3.24 g/kg) groups. After high-dose treatment for 2 weeks, the serum triglycerides and free fatty acids in SHR/cp rats were markedly reduced compared to controls. After 3 weeks of administration, the high dose of TNK significantly reduced the body weight and fat mass of SHR/cp rats without affecting food consumption. Serum fasting glucose and insulin levels in the TNK-treated groups decreased after 6 weeks of treatment. Furthermore, TNK-treated rats exhibited obvious improvements in glucose intolerance and insulin resistance. The improved glucose metabolism may be caused by the substantial reduction in serum lipids and body weight observed in SHR/cp rats starting at 3 weeks of TNK treatment. The mRNA expression of NAD+-dependent deacetylase sirtuin 1 (SIRT1) and genes related to fatty acid oxidation was markedly up-regulated in the muscle, liver and adipose tissue after TNK treatment. Furthermore, TNK promoted the deacetylation of two well-established SIRT1 targets, PPARγ coactivator 1α (PGC1α) and forkhead transcription factor 1 (FOXO1), and induced the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in different tissues. These observations suggested that TNK may be an alternative treatment for pre-diabetes and metabolic syndrome by inducing a gene expression switch toward fat oxidation through the activation of SIRT1 and AMPK signaling.
NEPROTIC FORM OF CHRONIC GLOMERULONEPHRITIS IN CHILDREN DISORDERS OF FAT METABOLISM AND ITS RESTORATION
Open the record for dataset details and reuse information.
Research on Mechanism of Massage Therapy on Energy Metabolism Disorder of Simple Obesity
ClinicalTrials.gov study NCT02339480. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Exploratory Efficacy of HSC835 in Patients With Inherited Metabolic Disorders (IMD)
ClinicalTrials.gov study NCT02715505. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
"The Effect of Comprehensive Non-pharmacological Treatment on Metabolic Disorders in Type 2 Diabetic Patients"
ClinicalTrials.gov study NCT04632823. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Study of Time-restricted Eating (TRE) to Clinical Pregnancy Rate in PCOS Women With Glucose Metabolism Disorder Via IVF/ICSI
ClinicalTrials.gov study NCT06666933. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Reliability of Serum Calcium to Phosphorus (Ca/P) Ratio as an Accurate and Inexpensive Tool to Define Disorders of Ca-P Metabolism
ClinicalTrials.gov study NCT03603444. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
ClinicalTrials.gov study NCT06559995. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle Disorders
ClinicalTrials.gov study NCT03797131. IPD Sharing: NO. Countries: 1. Publications: 0.
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children
ClinicalTrials.gov study NCT04414046. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.