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1,545 results for “microenvironment”
Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment
<p>This dataset can be interactively explored with VisCello (https://github.com/qinzhu/VisCello). Please install VisCello and use e.g. "cello("path_to/hcc_main_cello")" to load the human colon cancer single cell dataset.</p> <p> </p>
High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpoints.
<p>Final Seurat file (rds) produced from the immune cell analysis performed in "<strong>High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpoints</strong>.<em><strong>"</strong></em></p>
Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma Progression
<p>Spatial cellular organization patterns (COPs) in tumor microenvironment influence the tumor progression and therapeutic response, however, little is known about the cellular composition and functional potential of these multicellular structures during lung adenocarcinoma progression. Here, we integrate spatial transcriptomics with single cell RNA sequencing to characterize the local tumor and immunological landscape of samples from 8 patients with lung adenocarcinoma at different pathological stages. We identified ten COPs that show distinct associations with local immune states and clinical outcomes, including survival and therapy response. The local infiltration levels of regulatory and dysfunctional immune cells are increased with pathological progression. Cell-to-cell interactions between malignant cells and tumor microenvironment (TME) cells were involved in protumor immune state remodeling. Finally, we detected a group of malignant cells that were specifically located at the tumor boundary, representing a more aggressive state, were involved in the invasion of invasive adenocarcinoma (IAC). Altogether, these results can improve our understanding of the local microenvironment characteristics that underlie LUAD progression and may facilitate the identification of drug targets to prevent invasive progression and biomarkers for diagnosis.</p><p>If you're going to use this dataset, please cite 'Haojie Chen et al. 2023. Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma Progression. bioRxiv. https://doi.org/10.1101/2023.10.29.564580'</p>
The Study of the Relationship Between TWEAK/Fn14, JAK/STAT3 and IDO in the Immune Microenvironment of Endometrium in Repeated Implantation Failure
ClinicalTrials.gov study NCT02967419. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Prospective Biobanking Study in Cancer Patients Aiming at Better Understand the Link Between the Molecular Alterations of the Tumor Itself, Its Microenvironment and Immune Response (SCANDARE)
ClinicalTrials.gov study NCT03017573. IPD Sharing: YES. Countries: 1. Publications: 1.
Tumor Microenvironment in Ovarian Cancer
ClinicalTrials.gov study NCT06272240. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Morphological, Genetic and Tumour Microenvironment Characterisation in Uveal Melanoma
ClinicalTrials.gov study NCT05889481. IPD Sharing: NO. Countries: 1. Publications: 14.
DYNAmic Immune Microenvironment of HCC Treated With atezolIzumab Plus bevaCizumab
ClinicalTrials.gov study NCT04954339. IPD Sharing: NO. Countries: 1. Publications: 5.
Targeting the Tumor Microenvironment in R/M SCCHN
ClinicalTrials.gov study NCT03844763. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Study of the Association Between Tumor Microenvironment Macrophages and Treatment Response in Squamous Cell Carcinoma of the Anal Canal
ClinicalTrials.gov study NCT05019235. IPD Sharing: Not stated. Countries: 1. Publications: 5.
IMMUNOlogical Microenvironment in REctal Adenocarcinoma Treatment
ClinicalTrials.gov study NCT04915326. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
The Impact of Exercise on the Tumor Microenvironment in Patients With Lung Cancer
ClinicalTrials.gov study NCT07216209. IPD Sharing: NO. Countries: 1. Publications: 8.
Tumor Microenvironment in Patients With Localized Osteosarcoma Treated With Mifamurtide: a Translational Study
ClinicalTrials.gov study NCT03737435. IPD Sharing: NO. Countries: 1. Publications: 5.
Microbiota and Immune microEnvironment in Pouchitis
ClinicalTrials.gov study NCT03136419. IPD Sharing: NO. Countries: 1. Publications: 6.
Electrochemotherapy Induces Changes in the Tumor Microenvironment of Cutaneous and Subcutaneous Metastases in Patients With Cutaneous Melanoma
ClinicalTrials.gov study NCT06388252. IPD Sharing: UNDECIDED. Countries: 1. Publications: 26.
The Microenvironment in Barrett's Esophagus
ClinicalTrials.gov study NCT03060642. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Predictors of Normal Tissue Response From the Microenvironment in Radiotherapy for Prostate and Head-and-neck Cancer
ClinicalTrials.gov study NCT03294122. IPD Sharing: NO. Countries: 1. Publications: 7.
Effect of Autologous Cord Blood-mononuclear Cells Infusion on Immune Microenvironment in Infants Born Very Preterm in NICU
ClinicalTrials.gov study NCT05087498. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of the Tumor Microenvironment Affecting the Efficacy of Immunotherapy for Esophageal Cancer
ClinicalTrials.gov study NCT06219031. IPD Sharing: UNDECIDED. Countries: 1. Publications: 14.
The Study of Microglia/Macrophages Involved Dynamic Evolution of Glioma Microenvironment and the Function and Visualization of Targeted Molecules of Glioma
ClinicalTrials.gov study NCT04781764. IPD Sharing: NO. Countries: 1. Publications: 9.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.