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5,031 results for “mirnas”
miRNAs in primary open-angle glaucoma and ocular hypertension
<p>Glaucoma is a chronic neurodegenerative disease, which is the leading cause of irreversible blindness worldwide. As a response to high intraocular pressure, the clinical and molecular glaucoma biomarkers indicate the biological state of the visual system. Classical and uncovering novel biomarkers of glaucoma development and progression, follow-up, and monitoring the response to treatment are key objectives to improve vision outcomes. While the glaucoma imaging field has successfully validated biomarkers of disease progression, there is still a considerable need for developing new biomarkers of early glaucoma, that is, at the preclinical and initial glaucoma stages. Outstanding clinical trials and animal-model study designs, innovative technology, and analytical approaches in bioinformatics are essential tools to successfully uncover novel glaucoma biomarkers with a high potential for translation into clinical practice. To better understand the clinical and biochemical–molecular–genetic glaucoma pathogenesis, we conducted an analytical, observational, and case-comparative/control study in 358 primary open-angle glaucoma (POAG) patients and 226 comparative-control individuals to collect tears, aqueous humor, and blood to process for identifying POAG biomarkers by exploring several biological pathways, such as inflammation, neurotransmitter/neurotrophin alteration, oxidative stress, gene expression, miRNAs fingerprint and its biological targets, and vascular endothelial dysfunction. We are incredibly enthusiastic about gathering as much information as possible on POAG biomarkers to learn how this information can be used to better steer the diagnosis and therapy of glaucoma to prevent blindness in the predictable future.</p>
miRNA read counts and mature sequences
<p>Guppy post-filtered miRNA discovery set. Includes mature read counts, and sequences for three tissues.</p>
BSSE_QGF_61757 L010-L016 (Single-cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction)
<p>Fastq files from sequencing of sample BSSE_QGF_61757 L010 to L016</p> <p>Publication: https://doi.org/10.15252/msb.20188266</p>
BSSE_QGF_61757 L001-L009 (Single-cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction)
<p>Fastq files from sequencing of sample BSSE_QGF_61757 L001 to L009</p> <p>Publication: https://doi.org/10.15252/msb.20188266</p>
BSSE_QGF_61756 (Single-cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction)
<p>Fastq files from sequencing of sample BSSE_QGF_61756</p> <p>Publication: https://doi.org/10.15252/msb.20188266</p>
BSSE_QGF_61759 (Single-cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction)
<p>Fastq files from sequencing of sample BSSE_QGF_61759</p> <p>Publication: https://doi.org/10.15252/msb.20188266</p>
BSSE_QGF_61758 (Single-cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction)
<p>Fastq files from sequencing of sample BSSE_QGF_61758</p> <p>Publication: https://doi.org/10.15252/msb.20188266</p>
Data for: Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding
<p><span>The clinical potential of miRNA-based liquid biopsy has been largely limited by the heterogeneous sources in plasma and tedious assay processes. </span><span>Here we develop a precise and robust one-pot assay called dual-surface-protein</span><span>-guided</span><span> orthogonal recognition of tumor-derived exosomes and in-situ profiling of microRNAs (SORTER) to detect tumor-derived exosomal miRNAs and enhance the diagnostic accuracy of prostate cancer (PCa). The SORTER utilizes two allosteric aptamers against exosomal marker CD63 and tumor marker EpCAM to create an orthogonal labeling barcode and achieve selective sorting of tumor-specific exosome subtypes. Furthermore, the labeled barcode on tumor-derived exosomes initiated targeted membrane fusion with liposome probes to import miRNA detection reagents, enabling in-situ sensitive profiling of tumor-derived exosomal miRNAs. With a signature of six miRNAs, SORTER differentiated PCa and benign prostatic hyperplasia with an accuracy of 100%. Notably, the diagnostic accuracy reached 90.6% in the classification of metastatic and non-metastatic PCa. We envision that the SORTER will promote the clinical adaptability of miRNA-based liquid biopsy.</span></p>
Inflammation Severity and miRNA-126 in Trauma
ClinicalTrials.gov study NCT07291908. IPD Sharing: YES. Countries: 1. Publications: 2.
Detection of miRNAs in HPA Axis Function in Healthy Subjects
ClinicalTrials.gov study NCT04066647. IPD Sharing: NO. Countries: 1. Publications: 2.
Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)
ClinicalTrials.gov study NCT04321031. IPD Sharing: YES. Countries: 12. Publications: 2.
Data for: Genetic architecture modulates diet induced hepatic mRNA and miRNA expression profiles
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Notch directs telencephalic development and neuron fate determination by regulating miRNA levels
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EBAX-1/ZSWIM8 destabilizes miRNAs resulting in transgenerational inheritance of a predatory trait
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Data for: Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding
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miRNAs in primary open-angle glaucoma and ocular hypertension
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Data from:Investigation of urinary miRNA profile changes in amphotericin B-induced nephrotoxicity in C57BL/6 mouse, Sprague-Dawley rats and beagle dogs
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Data for: A novel and ubiquitous miRNA-involved regulatory module ensures precise phosphorylation of RNA polymerase II and proper transcription
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Data from: Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNA lin-4 during C. elegans development
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Association between diminished miRNA expression and acquired alterations of ABO antigen expression in leukemia patients
<p><strong>Supplementary Table S1.</strong> The clinical significance of miRNAs in acute leukemia.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.