Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,326
datasets available to search
ShareScore release 0.9.0
Dataset results
1,326 results for “neutrophil”
FIG. 4 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 4. Scatterplots showing multiple linear regression comparing Hellbender neutrophil: lymphocyte ratio and water characteristics for 2018. The first row of graphs depicts neutrophil: lymphocyte ratio on the y-axis and corresponding environmental variables on the x-axis; all other rows depict the relationship among water quality parameters assessed. R2 values are provided for each graph, the red line represents the overall trend line, and significant variables are indicated with an asterisk.
FIG. 3 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 3. Scatterplots showing regressions between Hellbender neutrophil: lymphocyte ratios and conductivity (A), pH (B), and dissolved oxygen (C), in 2017.
FIG. 1 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 1. Map of eight sites surveyed between 2017 and 2018 for Hellbenders, including North Fork Triplett Creek (NFTC) in Kentucky, Little Buffalo River (LBR), Hiwassee River (HR), Little River (LR), Doe River (DR), Tumbling Creek (TC), and Elk River (ER) in Tennessee, and South Fork New River (SFNR) in North Carolina.
StarDist_BF_Neutrophil_dataset
<p>This repository includes a StarDist deep learning model and its training and validation datasets for detecting neutrophils perfused over an endothelial cell monolayer. The model was trained on 36 manually annotated images, achieving an average F1 Score of 0.969. The dataset and model are intended for use in biomedical research, particularly for analyzing interactions between neutrophils and endothelial cells.</p> <h3>Specifications</h3> <ul> <li> <p>Model: StarDist for neutrophil detection on endothelial cells</p> </li> <li> <p>Training Dataset:</p> </li> <ul> <li> <p>Number of Images: 36 paired brightfield microscopy images and label masks</p> </li> <li> <p>Microscope: Nikon Eclipse Ti2-E, 20x objective</p> </li> <li> <p>Data Type: Brightfield microscopy images with manually segmented masks</p> </li> <li> <p>File Format: TIFF (.tif)</p> </li> <ul> <li> <p>Brightfield Images: 16-bit</p> </li> <li> <p>Masks: 8-bit</p> </li> </ul> <li> <p>Image Size: 1024 x 1022 pixels (Pixel size: 650 nm)</p> </li> </ul> <li> <p>Training Parameters:</p> </li> <ul> <li> <p>Epochs: 400</p> </li> <li> <p>Patch Size: 992 x 992 pixels</p> </li> <li> <p>Batch Size: 2</p> </li> </ul> <li> <p>Performance:</p> </li> <ul> <li> <p>Average F1 Score: 0.969</p> </li> <li> <p>Average IoU: 0.914</p> </li> </ul> <li> <p>Model Training: Conducted using ZeroCostDL4Mic (<a href="https://github.com/HenriquesLab/ZeroCostDL4Mic/wiki/Stardist">https://github.com/HenriquesLab/ZeroCostDL4Mic/wiki</a>)</p> </li> </ul> <div> <h3>Reference</h3> <div><strong>Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers</strong></div> </div> <div>Gautier Follain, Sujan Ghimire, Joanna W. Pylvänäinen, Monika Vaitkevičiūtė, Diana Wurzinger, Camilo Guzmán, James RW Conway, Michal Dibus, Sanna Oikari, Kirsi Rilla, Marko Salmi, Johanna Ivaska, Guillaume Jacquemet</div> <div>bioRxiv 2024.09.30.615654; doi: <a href="https://www.biorxiv.org/content/10.1101/2024.09.30.615654v1">https://doi.org/10.1101/2024.09.30.615654</a></div>
Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps
<p>Background: polymorphonuclear neutrophils (PMNs) are main effector cells in the inflammatory responses. The significance of PMN infiltration in tumor microenvironment remains to be clarified. Metastatic melanoma is the most lethal type of skin cancer with an increasing incidence over the last decades. Few studies investigated the role of PMNs in human melanoma. The aim of this study was to investigate the role of PMNs and their mediators in human melanoma; (2) Methods: highly purified human PMNs from healthy donors were stimulated, in vitro, with conditioned media derived from the melanoma cell lines SKMEL28 and A375 (melanoma-CM) as well as from primary melanocytes as control. PMN functions (chemotaxis, survival, activation, cell tracking, morphology and NETs release) were evaluated; (3) Results: we found that the A375 cell line produced soluble factors able to promote PMN chemotaxis, survival, activation, and to modify PMN morphological changes and kinetic properties. Furthermore, both melanoma cell lines CM induced activation and the release of neutrophil extracellular traps (NETs) from PMNs. By contrast, primary melanocytes CM did not modify any PMN biological behavior. In addition, serum levels of myeloperoxidase (MPO), matrix metalloprotease-9 (MMP-9), CXCL8/IL-8, granulocyte and monocyte colony stimulating factor (GM-CSF) and NETs components were significantly increased in advanced melanoma patients compared to healthy controls; (4) Conclusions: melanoma cell lines produce soluble factors able to ‘educate’ PMNs towards an activated functional state. Metastatic melanoma patients display increased circulating levels of neutrophil-related mediators and NETs, suggesting that a neutrophil-related signature exists in metastatic melanoma patients. Further investigations are needed to better understand the role of these “tumor-educated neutrophils” in modifying melanoma cell behavior.</p>
Neutrophilic Asthma Study With Navarixin (MK-7123, SCH 527123) (MK-7123-017)(COMPLETED)
ClinicalTrials.gov study NCT00632502. IPD Sharing: YES. Countries: 0. Publications: 1.
Covid-19: Possible Role of Neutrophil Extracellular Traps
ClinicalTrials.gov study NCT04412382. IPD Sharing: YES. Countries: 1. Publications: 1.
Neutrophil Imaging in Healthy Subjects Following Lipopolysaccharide or Saline Challenge and in Subjects With Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT02551614. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Plasma Neutrophil Gelatinase-associated Lipocalin (NGAL) as Early Biomarker for Renal Dysfunction and Good Neurologic Outcome in Out of Hospital Cardiac Arrest Patients
ClinicalTrials.gov study NCT01987466. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neutrophil Function During Therapy With Protease Inhibitors in Chronic Hepatitis C
ClinicalTrials.gov study NCT02545335. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Neutrophil Side Fluorescent Light (NEU-SFL) in COVID-19 Patients
ClinicalTrials.gov study NCT05413824. IPD Sharing: NO. Countries: 1. Publications: 1.
Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis
ClinicalTrials.gov study NCT06462768. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neutrophil Gelatinase-Associated Lipcalin (NGAL) Evaluation Along With B-Type Natriuretic Peptide in Acutely Decompensated HF
ClinicalTrials.gov study NCT00693745. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Interferon-lambda: Novel Biologics for Controlling Neutrophil-mediated Pathology in Rheumatic Diseases?
ClinicalTrials.gov study NCT02498808. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Efficacy and Safety of Low-Level Tragus Stimulation on Heart Rate Variability, Neutrophil-Lymphocyte Ratio, and Major Adverse Cardiovascular Events in Patients With ST-Segment Elevation Myocardial
ClinicalTrials.gov study NCT06537583. IPD Sharing: NO. Countries: 1. Publications: 2.
Role of Neutrophil Activation in Anaphylaxis to Neuro-Muscular Blocking Agents
ClinicalTrials.gov study NCT01637220. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis
ClinicalTrials.gov study NCT00128895. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Plasma Neutrophil Gelatinase - Associated Lipocalin (NGAL) Levels
ClinicalTrials.gov study NCT03607279. IPD Sharing: NO. Countries: 1. Publications: 2.
Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression and Myelodysplastic Syndromes
ClinicalTrials.gov study NCT03363399. IPD Sharing: YES. Countries: 1. Publications: 2.
Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates
ClinicalTrials.gov study NCT01735552. IPD Sharing: Not stated. Countries: 1. Publications: 9.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.