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189 results for “nociception”
Pain Response to Cannabidiol in Induced Acute Nociceptive Pain, Allodynia and Hyperalgesia By Using a Model Mimicking Acute Pain in Healthy Adults
ClinicalTrials.gov study NCT03985995. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Different Objective Nociceptive Measurement Methods During Surgery
ClinicalTrials.gov study NCT05218551. IPD Sharing: NO. Countries: 1. Publications: 1.
Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study
<p>Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibers induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers we applied HFS to the left or right volar forearm. Before and after applying HFS we delivered single electrical test stimuli through the HFS electrode while a second electrode at the contralateral arm served as control condition. Moreover, to test the efficacy of the HFS protocol we quantified changes in mechanical pinprick sensitivity before and after HFS of the skin surrounding both electrodes. The perceived intensity was collected for both electrical and mechanical stimuli. After HFS, the perceived pain intensity elicited by the mechanical pinprick stimuli applied on the skin surrounding the HFS-treated site was significantly higher compared to control site (heterotopic effect). Furthermore, we found a higher perceived pain intensity for single electrical stimuli delivered to the HFS-treated site compared to the control site (homotopic effect). Whether the homotopic effect reflects a perceptual correlate of homosynaptic LTP remains to be elucidated.</p>
Data from: Mechanical conflict system: a novel operant method for the assessment of nociceptive behavior
A new operant test for preclinical pain research, termed the Mechanical Conflict System (MCS), is presented. Rats were given a choice either to remain in a brightly lit compartment or to escape to a dark compartment by crossing an array of height-adjustable nociceptive probes. Latency to escape the light compartment was evaluated with varying probe heights (0, .5, 1, 2, 3, and 4 mm above compartment floor) in rats with neuropathic pain induced by constriction nerve injury (CCI) and in naive control rats. Escape responses in CCI rats were assessed following intraperitoneal administration of pregabalin (10 and 30 mg/kg), morphine (2.5 and 5 mg/kg), and the tachykinin NK1 receptor antagonist, RP 67580 (1 and 10 mg/kg). Results indicate that escape latency increased as a function of probe height in both naive and CCI rats. Pregabalin (10 and 30 mg/kg) and morphine (5 mg/kg), but not RP 67580, decreased latency to escape in CCI rats suggesting an antinociceptive effect. In contrast, morphine (10 mg/kg) but not pregabalin (30 mg/kg) increased escape latency in naive rats suggesting a possible anxiolytic action of morphine in response to light-induced fear. No order effects following multiple test sessions were observed. We conclude that the MCS is a valid method to assess behavioral signs of affective pain in rodents.
Figures 2-4 from: Yang Y-G, Shang G-Z, Wu X-Q, Chen H-Q, Wu Y, Cao Y-F, Bian J-H (2021) Effects of parasites and predators on nociception: decreases analgesia reduces overwinter survival in root voles (Rodentia: Cricetidae). Zoologia 38: 1-9. https://doi.org/10.3897/zoologia.38.e67845
Figures 2-4 Monthly apparent survival probability (2), population change rate (3) and population size (4) of root voles during the live-trapping sessions under two different groups. H signifies that root voles with high thermal responses latency; L signifies that root voles with low thermal responses latency. n = 48 and 48 for H and L groups. Data were expressed as the mean ± SE.
Figure 1 from: Yang Y-G, Shang G-Z, Wu X-Q, Chen H-Q, Wu Y, Cao Y-F, Bian J-H (2021) Effects of parasites and predators on nociception: decreases analgesia reduces overwinter survival in root voles (Rodentia: Cricetidae). Zoologia 38: 1-9. https://doi.org/10.3897/zoologia.38.e67845
Figure 1 Vole nociceptive latencies among the four treatments. N=10, 10, 10 and 10 for the PR+PA+, PR+PA-, PR-PA+ and PR-PA- groups, respectively. Different letters represent significant difference between four treatments (p < 0.05). Data were expressed as the mean ± SE.
How is the nociceptive withdrawal reflex influenced by increasing doses of propofol in pigs?
<p>The files contain the nocicpetive withdrawal reflex thresholds for each single pig and for each single day.<br> They have been recorded continuously (for more details see main text) from the beginning to the end of the experiment.</p> <p>Each Excel file is dedicated to one pig. In each Excel file, there are 3 worksheets that refer to each experimental day.<br> All the parameters recorded from the Dolosys have been reported (data are presented as downloaded from the device), namely:</p> <p>stimulus_no date time stimulus_intensity [mA] threshold [mA] imp_stim [ohm] imp_emg_red [ohm] imp_emg_black [ohm] imp_emg_white [ohm] noise_level threshold_reliability scoring_value scoring_cutoff_value noise_max [uV] noise_mean [uV] noise_sd [uV] reflex_max [uV] reflex_mean [uV] reflex_sd [uV] NRS noise_start [ms] noise_end [ms] reflex_start [ms] reflex_end [ms] measured_current [mA] measured_voltage [V]</p>
Monitoring Nociception Using NoL Index to Reduce Opioid-Related Complications in Laparoscopic Abdominal Surgery
ClinicalTrials.gov study NCT06437743. IPD Sharing: NO. Countries: 0. Publications: 1.
BIS and Entropy Nociception Monitoring
ClinicalTrials.gov study NCT02585466. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Nociceptive Pain Fiber Response
ClinicalTrials.gov study NCT02696070. IPD Sharing: NO. Countries: 1. Publications: 0.
The Nociception Level (NOL) Index for Pain Assessment in the Adult Intensive Care Unit
ClinicalTrials.gov study NCT05339737. IPD Sharing: NO. Countries: 0. Publications: 1.
Analgesia Nociception Index for Pain Monitoring in Intensive Care Units
ClinicalTrials.gov study NCT05313789. IPD Sharing: NO. Countries: 0. Publications: 6.
Validation of a Nociception Monitor in Healthy Volunteers
ClinicalTrials.gov study NCT02589093. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effects of IV Administration of Ketamine on the Analgesia Nociception Index (ANI) Measured With the PhysioDoloris
ClinicalTrials.gov study NCT01717521. IPD Sharing: NO. Countries: 1. Publications: 0.
Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study
Open the record for dataset details and reuse information.
Data from: Mechanical conflict system: a novel operant method for the assessment of nociceptive behavior
Open the record for dataset details and reuse information.
Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs
GEO Series GSE284380. Drosophila melanogaster. 55 samples. Type: Expression profiling by high throughput sequencing.
Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming. [RNA-Seq]
GEO Series GSE224208. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Nociceptive neurons interact with gastric cancer cells via a CGRP/Ramp1 axis to promote tumor progression
GEO Series GSE243578. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Whole larvae and nociceptive neuron RNA-Seq samples
GEO Series GSE99711. Drosophila melanogaster. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.