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1,554 results for “nucleus”
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways_CAL27_RNAseq_siHUWE1
<p>RNA-seq data from CAL27 cells 3 days after transfection with one of three siRNAs (1, 155 or 969) targeting human HUWE1. si155 corresponds to sequence #2, and si969 corresponds to sequence #3 in Monda et al. <em>Cell Reports</em>. 2023. Each transfection was performed in triplicate and analyzed with paired-end reads.</p> <p>See DOI:10.5281/zenodo.7839090 for the CAL27 siControl dataset.</p> <p>See DOI:10.5281/zenodo.7839102 for the CAL27 siHAPSTR1 dataset.</p>
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways_CAL27_RNAseq_Control
<p>RNA-seq data from CAL27 cells 3 days after transfection with one of three control non-targeting siRNAs. The transfection was performed in triplicate and analyzed with paired-end reads.</p> <p>See DOI: 10.5281/zenodo.7839102 for the CAL27 siHAPSTR1 dataset.</p> <p>See DOI: 10.5281/zenodo.7839096 for the CAL27 siHUWE1 dataset.</p>
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways_CAL27_RNAseq_siHAPSTR1
<p>RNA-seq data from CAL27 cells transfected with one of three siRNAs targeting human HAPSTR1. Each transfection was performed in triplicate and analyzed with paired-end reads.</p> <p>See DOI:10.5281/zenodo.7839090 for the CAL27 siControl dataset.</p> <p>See DOI: 10.5281/zenodo.7839096 for the CAL27 siHUWE1 dataset.</p>
Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
<p>In substance use disorders, drug use as unconditioned stimulus (US) reinforces drug taking. Meanwhile, drug-associated cues (conditioned stimulus, CS) also gain incentive salience to promote drug seeking. The basolateral amygdala (BLA) is implicated in both US- and CS-mediated responses. Here, we show that two genetically distinct BLA neuronal types, expressing Rspo2 versus Ppp1r1b, respectively, project to the nucleus accumbens (NAc) and form monosynaptic connections with both dopamine D1 and D2 receptor-expressing neurons. While intra-NAc stimulation of Rspo2 or Ppp1r1b presynaptic terminals establishes intracranial self-stimulation (ICSS), only Ppp1r1b-stimulated mice exhibit cue-induced ICSS seeking. Furthermore, increasing versus decreasing the Ppp1r1b-to-NAc, but not Rspo2-to-NAc, subprojection increases versus decreases cue-induced cocaine seeking after cocaine withdrawal. Thus, while both BLA-to-NAc subprojections contribute to US-mediated responses, the Ppp1r1b subprojection selectively encodes CS-mediated reward and drug reinforcement. Such differential circuit representations may provide insights into precise understanding and manipulation of drug- versus cue-induced drug seeking and relapse.</p>
Safety and Efficacy of Remote Programming of Nucleus Cochlear Implants
ClinicalTrials.gov study NCT02644343. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Clinical Evaluation of the Cochlear Nucleus CI532 Cochlear Implant in Adults
ClinicalTrials.gov study NCT03007472. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Phase II Subthalamic Nucleus (STN) vs. Globus Pallidus (GPi) Trial
ClinicalTrials.gov study NCT01076452. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Evaluation of the Nucleus Hybrid™ L24 Cochlear Implant System
ClinicalTrials.gov study NCT00678899. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Electrical Stimulation of the Dentate Nucleus for Upper Extremity Hemiparesis Due to Ischemic Stroke
ClinicalTrials.gov study NCT02835443. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluating the User Performance and Experience of Nucleus Pen vs. Commercially Available Pen Needle
ClinicalTrials.gov study NCT03267264. IPD Sharing: NO. Countries: 1. Publications: 1.
Implantation of the Cochlear™ Nucleus® Hybrid S Round Window (S-RW) in Adults
ClinicalTrials.gov study NCT02638883. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Clinical Investigation of the Nucleus® CI532 Cochlear Implant
ClinicalTrials.gov study NCT02392403. IPD Sharing: Not stated. Countries: 4. Publications: 1.
The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease
ClinicalTrials.gov study NCT05905302. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Investigation of New CI Delivery Models in an Adult Nucleus CI Population
ClinicalTrials.gov study NCT03304106. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency
ClinicalTrials.gov study NCT04383665. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Dexmedetomidine on Activity in the Subthalamic Nucleus
ClinicalTrials.gov study NCT01721460. IPD Sharing: NO. Countries: 1. Publications: 1.
Single-nucleus profiling highlights the all-brain echinoderm nervous system
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Data for: Multimodal convergence in the pedunculopontine tegmental nucleus: motor, sensory, and theta-frequency inputs influence the activity of single neurons
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Data from: Diurnal variation of brain activity in the human suprachiasmatic nucleus
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Simulations of cochlear nucleus bushy cells reconstructed from serial blockface electron microscopy (V1.3)
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.