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69
datasets available to search
ShareScore release 0.9.0
Dataset results
69 results for “plasma membrane”
Neurospora crassa transcriptomics reveals oxidative stress and plasma membrane homeostasis biology genes as key targets in response to chitosan
GEO Series GSE75293. Neurospora crassa OR74A. 6 samples. Type: Expression profiling by high throughput sequencing.
Sub-membrane actin rings compartmentalize the plasma membrane
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Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells
GEO Series GSE9894. Homo sapiens. 12 samples. Type: Expression profiling by array.
Plasma Membrane Integrity Signaling
GEO Series GSE166538. Homo sapiens; Mus musculus. 59 samples. Type: Expression profiling by high throughput sequencing.
Transcript profiling of Arabidopsis plasma membrane proton pump mutants
GEO Series GSE34202. Arabidopsis thaliana. 8 samples. Type: Expression profiling by array.
Disruption of the Cyp7b1 Gene in Rats Increases Secretion of Very Low Density Lipoproteins by Decreasing Low Density Lipoprotein Receptor on Plasma Membrane
GEO Series GSE267177. Rattus norvegicus. 16 samples. Type: Expression profiling by high throughput sequencing.
Exploring in vivo cholesterol-mediated interactions between activated EGF receptors in plasma membrane with single-molecule optical tracking
<p><strong>Background</strong>:: The first step in many cellular signaling processes occurs at various types of receptors in the plasma membrane. Membrane cholesterol can alter these signaling pathways of living cells. However, the process in which the interaction of activated receptors is modulated by cholesterol remains unclear.</p> <p><strong>Methods</strong>:: In this study, we measured single-molecule optical trajectories of epidermal growth factor receptors moving in the plasma membranes of two cancerous cell lines and one normal endothelial cell line. A stochastic model was developed and applied to identify critical information from single-molecule trajectories.</p> <p><strong>Results</strong>:: We discovered that unliganded epidermal growth factor receptors may reside nearby cholesterol-riched regions of the plasma membrane and can move into these lipid domains when subjected to ligand binding. The amount of membrane cholesterol considerably affects the stability of correlated motion of activated epidermal growth factor receptors.</p> <p><strong>Conclusions</strong>:: Our results provide single-molecule evidence of membrane cholesterol in regulating signaling receptors. Because the three cell lines used for this study are quite diverse, our results may be useful to shed light on the mechanism of cholesterol-mediated interaction between activated receptors in live cells. </p>
A plasma membrane calcium ATPase functions in FLS2-mediated immunity
GEO Series GSE31517. Arabidopsis thaliana. 6 samples. Type: Expression profiling by array.
Data from: Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity
Recently evolved alleles of Apolipoprotein L-1 (<em>APOL1</em>) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels within the parasite, causing lysis. While the correlation to kidney disease is robust, there is little consensus concerning the underlying disease mechanism. We show in human cells that the APOL1 renal risk variants have a population of active channels at the plasma membrane, which results in an influx of both Na<sup>+</sup> and Ca<sup>2+</sup>. We propose a model wherein APOL1 channel activity is the upstream event causing cell death, and that the activate-state, plasma membrane-localized channel represents the ideal drug target to combat APOL1-mediated kidney disease.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.