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133 results for “polyunsaturated fatty acids”
Migrant blackbirds, Turdus merula, have higher plasma levels of polyunsaturated fatty acids compared to residents, but not enhanced fatty acid unsaturation index
Birds have been observed to have dietary preferences for unsaturated fatty acids during migration. Polyunsaturated fatty acids (PUFAs) may increase the exercise performance of migrant birds; however, PUFAs are also peroxidation prone and might therefore incur increased costs in terms of enhanced oxidative damage in migratory individuals. To shed light on this potential constraint, we analysed plasma fatty acid (FA) composition and estimated the unsaturation index as a proxy for susceptibility to lipid peroxidation of migrants and residents of the partially migratory common blackbird (Turdus merula) at a stop-over site during autumn migration. As predicted, migrant birds had higher relative and absolute levels of PUFAs compared to resident birds. This included the strictly dietary ω-3 PUFA α-linolenic acid, suggesting a dietary and/or storage preference for these FAs in migrants. Interestingly, the FA unsaturation index did not differ between migrants and residents. These findings suggest a mechanism where birds alter their levels of metabolic substrate without simultaneously increasing the susceptibility of the substrate to lipid peroxidation. In summary, our results are in line with the hypothesis that increased exercise performance during migration might be constrained by oxidative stress, which is manifested in changes in the composition of key FAs to retain the unsaturation index constant despite the increased levels of peroxidizable PUFAs.
Dietary availability determines metabolic conversion of long-chain polyunsaturated fatty acids in spiders: a dual compound-specific stable isotope approach
<p>The following dataset contains fatty acid contents (in mg.g<sup>-1</sup> and in %), stable isotopes (‰), and compound specific isotopic analyses of carbon and hydrogen (‰) data for insects (terrestrial and semi-aquatic) and spiders collected around Lake Lunz (47°85'N, 15°05'E), Austria from June to September 2020. Measurements were done after storage at -80°C for 2 hours, and freeze drying (24h), followed by taxonomic identification. Analytical details can be found in "Dietary availability determines metabolic conversion of long-chain polyunsaturated fatty acids in spiders: a dual compound-specific stable isotope approach" by Mathieu-Resuge, Margaux; Pilecky, Matthias; Twining, Cornelia; Martin-Creuzburg, Dominik; Parmar, Tarn-Preet; Vitecek, Simon; Kainz, Martin. Oikos (2021), DOI: 10.1111/oik.08513</p>
Hydrogen isotopes (d2H) of polyunsaturated fatty acids track bioconversion by zooplankton
<p>Organisms at the base of aquatic food webs synthesize essential nutrients, such as omega-3 polyunsaturated fatty acids (n-3 PUFA), which are transferred to consumers at higher trophic levels. Many consumers, requiring n-3 long-chain (LC) PUFA, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have limited ability to bioconvert them from the essential dietary precursor α-linolenic acid (ALA) and thus rely on dietary provision of LC-PUFA. We investigated LC-PUFA metabolism in freshwater zooplankton using stable hydrogen isotopes (<i>d</i><sup>2</sup>H) of fatty acids as tracers. We conducted feeding experiments with the freshwater keystone grazer <i>Daphnia</i> to quantify changes in the <i>d</i><sup>2</sup>H value of body FA in response to the FA composition of their food and the <i>d</i><sup>2</sup>H value of the ambient water. The isotopic composition of LC-PUFA changed in <i>Daphnia</i>, depending on the integration of <sup>2</sup>H from ambient water during <i>de novo </i>synthesis or bioconversion from dietary precursors, allowing us to distinguish dietary from bioconverted EPA in body tissue. We tested the applicability of these laboratory findings in a field setting by analyzing <i>d</i><sup>2</sup>H values of PUFA in primary producers and consumers in eutrophic ponds to track EPA sources of zooplankton. Multilinear regression models that included conversion of ALA to EPA correlated better with zooplankton <i>d</i><sup>2</sup>H<sub>EPA</sub> than seston <i>d</i><sup>2</sup>H<sub>EPA</sub> at low dietary EPA supply. This study provides evidence that zooplankton can compensate for low dietary EPA supply by activating LC-PUFA biosynthesis and shows that herbivorous zooplankton play a crucial role in upgrading FA for higher trophic levels during low dietary EPA supply.</p>
Lipid polyunsaturated fatty acid chains in mouse kidneys were increased within 5 minutes after a single high dose whole body irradiation
<p>figure and table</p>
Fish, Polyunsaturated Fatty Acids Intake and Mortality
ClinicalTrials.gov study NCT03155659. IPD Sharing: Not stated. Countries: 0. Publications: 3.
The Effect of Omega-3 Polyunsaturated Fatty Acids in Congestive Heart Failure
ClinicalTrials.gov study NCT00944229. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Polyunsaturated Fatty Acids (PUFA) Status and Cognitive Function in Healthy Young Adults
ClinicalTrials.gov study NCT01075958. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence
ClinicalTrials.gov study NCT01735279. IPD Sharing: NO. Countries: 1. Publications: 0.
Cardiometabolic Benefits of Omega-3 Polyunsaturated Fatty Acids
ClinicalTrials.gov study NCT03378232. IPD Sharing: NO. Countries: 0. Publications: 8.
Omega-3-Index Response to Eating Poultry Foods Naturally Enriched With Omega-3 Polyunsaturated Fatty Acids
ClinicalTrials.gov study NCT06259825. IPD Sharing: YES. Countries: 1. Publications: 0.
Fish, Polyunsaturated Fatty Acids Intake and Type 2 Diabetes
ClinicalTrials.gov study NCT03259321. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Dietary availability determines metabolic conversion of long-chain polyunsaturated fatty acids in spiders: a dual compound-specific stable isotope approach
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Hydrogen isotopes (d2H) of polyunsaturated fatty acids track bioconversion by zooplankton
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Data from: Experimental reduction in dietary omega-3 polyunsaturated fatty acids depresses sperm competitiveness
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Migrant blackbirds, Turdus merula, have higher plasma levels of polyunsaturated fatty acids compared to residents, but not enhanced fatty acid unsaturation index
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Polyunsaturated Fatty Acids from Astrocytes Activates PPAR Gamma Signaling in Cancer Cells to Promote Brain Metastasis
GEO Series GSE137687. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
C. elegans LPIN-1 moderates lifespan-shortening effects of dietary glucose via maintaining ω-6 polyunsaturated fatty acids
GEO Series GSE138035. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome prior to injury in a diet-dependent manner
GEO Series GSE194403. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision loss in mice
GEO Series GSE303793. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters Hepatic Polyunsaturated Fatty Acid Metabolism and Eicosanoid Biosynthesis in Female Sprague-Dawley Rats
GEO Series GSE110294. Rattus norvegicus. 34 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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