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ShareScore release 0.7.1
Dataset results
67 results for “potassium channel”
Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development
GEO Series GSE282716. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events
GEO Series GSE146667. Homo sapiens. 28 samples. Type: Other.
Modulation of calcium activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker- like cells
GEO Series GSE18660. Mus musculus. 10 samples. Type: Expression profiling by array.
A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance [RNA-seq]
GEO Series GSE277171. Mus musculus. 70 samples. Type: Expression profiling by high throughput sequencing.
Roles of voltage-gated potassium channels in the maintenance of pancreatic cancer stem cells
GEO Series GSE172185. Homo sapiens. 2 samples. Type: Expression profiling by array.
A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance [DNA-seq]
GEO Series GSE277172. Mus musculus. 9 samples. Type: Other.
Mexiletine Shortens the QT Interval in Patients With Potassium Channel–Mediated Type 2 Long QT Syndrome
<p><strong>BACKGROUND</strong>: Long QT syndrome is a potentially lethal yet highly treatable cardiac channelopathy. Although β-blocker therapy is standard for most patients, concomitant therapy with sodium channel blockers, like mexiletine, is often utilized for patients with sodium channel–mediated type 3 long QT syndrome (LQT3). The potential role of sodium channel blockers in patients with potassium channel–mediated long QT syndrome (ie, LQT1 and LQT2) has not been investigated in detail.</p> <p><strong>METHODS</strong>: We performed a retrospective chart review on 12 patients (5 females; median age at diagnosis 14.1 years (interquartile range [IQR], 7.7–23; range, 0–59, median heart rate–corrected QT interval [QTc] at diagnosis 557 ms (IQR, 529–605) with genetically established LQT2 (10) or a combination of LQT1/LQT2 (1) or LQT2/LQT3 (1), who received mexiletine. Data were collected on symptomatic status, treatments, and breakthrough cardiac events after diagnosis and initiation of treatment. Additionally, 12-lead ECGs were collected at diagnosis, before initiation of mexiletine and following mexiletine to evaluate the drug’s effect on QTc.</p> <p><strong>RESULTS</strong>: Before diagnosis, 6 patients were symptomatic and, before initiation of mexiletine, 4 patients experienced ≥1 breakthrough cardiac event on β-blocker. Median age at first mexiletine dose was 24.3 years (IQR, 14–32.4). After mexiletine, the median QTc decreased by 65±45 ms from 547 ms (IQR, 488–558) premexiletine to 470 ms (IQR, 409–529) postmexiletine (P=0.0005) for all patients. In 8 patients (67%), the QTc decreased by ≥ 40 ms with a mean decrease in QTc of 91 ms (P < 0.008).<br> For the 11 patients maintained on mexiletine therapy, there have been no breakthrough cardiac events during follow-up.</p> <p><strong>CONCLUSIONS</strong>: Although commonly prescribed in patients with LQT3, mexiletine also shortens the QTc significantly in two-thirds of a small subset of patients with potassium channel–mediated LQT2. In patients with LQT2, pharmacological targeting of the physiological late sodium current may provide added therapeutic efficacy to β-blocker therapy.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.