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418
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ShareScore release 0.9.0
Dataset results
418 results for “prefrontal cortex”
Data from: Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior
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Sex differences in prefrontal cortex microglia morphology: impact of a two-hit model of adversity throughout development
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RNAseq data from: Medial prefrontal cortex samples of glutamate dehydrogenase-deficient mice, stress-exposed or -naive, and their Nestin-Cre+ controls
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Memory reactivation in rat medial prefrontal cortex occurs in a subtype of cortical UP state during slow-wave sleep
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Data from: The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice
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Behavioral context affects social signal representations within single primate prefrontal cortex neurons
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Hippocampus and Prefrontal Cortex in Rat's Brain
Drawing uploaded to scidraw.io on: 10 November 2019
Hippocampus and Prefrontal Cortex in Rat's Brain
Drawing uploaded to scidraw.io on: 10 November 2019
Data from: Delay of gratification is associated with white matter connectivity in the dorsal prefrontal cortex: a diffusion tensor imaging study in chimpanzees (Pan troglodytes)
Individual variability in delay of gratification (DG) is associated with a number of important outcomes in both non-human and human primates. Using diffusion tensor imaging (DTI), this study describes the relationship between probabilistic estimates of white matter tracts projecting from the caudate to the prefrontal cortex (PFC) and DG abilities in a sample of 49 captive chimpanzees (Pan troglodytes). After accounting for time between collection of DTI scans and DG measurement, age and sex, higher white matter connectivity between the caudate and right dorsal PFC was found to be significantly associated with the acquisition (i.e. training phase) but not the maintenance of DG abilities. No other associations were found to be significant. The integrity of white matter connectivity between regions of the striatum and the PFC appear to be associated with inhibitory control in chimpanzees, with perturbations on this circuit potentially leading to a variety of maladaptive outcomes. Additionally, results have potential translational implications for understanding the pathophysiology of a number of psychiatric and clinical outcomes in humans.
Data from: Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption
Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation. However, the precise role of the PFC in mediating reward responses to highly palatable foods (HPF) after REM sleep deprivation is unclear. We selectively reduced REM sleep in mice over a 25–48 hr period and chemogenetically inhibited the medial PFC (mPFC) by using an altered glutamate-gated and ivermectin-gated chloride channel that facilitated neuronal inhibition through hyperpolarizing infected neurons. HPF consumption was measured while the mPFC was inactivated and REM sleep loss was induced. We found that REM sleep loss increased HPF consumption compared to control animals. However, mPFC inactivation reversed the effect of REM sleep loss on sucrose consumption without affecting fat consumption. Our findings provide, for the first time, a causal link between REM sleep, mPFC function and HPF consumption.
Ventromedial prefrontal cortex drives the prioritization of self-associated stimuli in working memory
<p><span>Humans show a pervasive bias for processing self- over other-related information, including in working memory (WM), where people prioritize the maintenance of self- (over other-) associated cues. To elucidate the neural mechanisms underlying this self-bias, we paired a self- vs. other-associated spatial WM task with functional magnetic resonance imaging (fMRI) and transcranial direct current stimulation (tDCS). Maintaining self- (over other-) associated cues resulted in enhanced delay-period activity in classic WM regions (frontoparietal cortex), and in superior multivoxel pattern decoding of the cue locations from visual cortex. Moreover, ventromedial prefrontal cortex (VMPFC) displayed enhanced functional connectivity with WM regions during maintenance of self-associated cues, which predicted individuals' behavioral self-prioritization effects. In a follow-up tDCS experiment, we targeted VMPFC with either excitatory (anodal), inhibitory (cathodal), or sham tDCS. Cathodal tDCS eliminated the self-prioritization effect. These findings provide strong converging evidence for a causal role of VMPFC in driving self-prioritization effects in WM.</span></p>
TZO - Working memory performance in glioma patients is associated with functional connectivity between the right dorsolateral prefrontal cortex and default mode network
<p>Data files hosted on Figshare for "Working memory performance in glioma patients is associated with functional connectivity between the right dorsolateral prefrontal cortex and default mode network".</p> <p>Contains functional connectivity matrices, clinical variables, and working memory performance scores of 45 glioma patients.</p>
The Effect of Repeated Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
ClinicalTrials.gov study NCT02674516. IPD Sharing: NO. Countries: 1. Publications: 0.
Probing the Dorsolateral Prefrontal Cortex and Central Executive Network for Improving Neuromodulation in Depression
ClinicalTrials.gov study NCT05224063. IPD Sharing: Not stated. Countries: 1. Publications: 0.
rTMS To The Dorsolateral Prefrontal Cortex For Patients With Subjective Idiopathic Tinnitus. A Pilot Study
ClinicalTrials.gov study NCT00886938. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Causal Evidence for Lateral Prefrontal Cortex Dynamics Supporting Cognitive Control
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Data from: Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption
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Data from: Delay of gratification is associated with white matter connectivity in the dorsal prefrontal cortex: a diffusion tensor imaging study in chimpanzees (Pan troglodytes)
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Ventromedial prefrontal cortex drives the prioritization of self-associated stimuli in working memory
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The influence of the estrous cycle on sex differences in the rat adult medial prefrontal cortex transcriptome [ChIP-Seq]
GEO Series GSE69772. Rattus norvegicus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.