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166 results for “radiation exposure”
Identifying radiation exposure biomarkers from mouse blood transcriptome
Here we present a whole-genome survey of the murine transcriptomic response to physiologically-relevant radiation doses 2 and 8 Gy. There are 18 distinct biological samples here. Mice were exposed to ionizing radiation (Cesium-138 source) and whole blood was collected by cardiac puncture 6 hours post treatment. Doses were 0 (7 samples) 2 (5 samples) and 8 (6 samples) gy.
['Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure']
['Cancer-causing genome instability is a major concern during space travel due to exposure of astronauts to potent sources of high-linear energy transfer (LET) ionizing radiation. Hematopoietic stem cells (HSCs) are particularly susceptible to genotoxic stress, and accumulation of damage can lead to HSC dysfunction and oncogenesis. Our group recently demonstrated that aging human HSCs accumulate microsatellite instability coincident with loss of MLH1, a DNA Mismatch Repair (MMR) protein, which could reasonably predispose to radiation-induced HSC malignancies. Therefore, in an effort to reduce risk uncertainty for cancer development during deep space travel, we employed an Mlh1+/- mouse model to study the effects high-LET 56Fe ion space-like radiation. Irradiated Mlh1+/- mice showed a significantly higher incidence of lymphomagenesis with 56Fe ions compared to γ-rays and unirradiated mice, and malignancy correlated with increased MSI in the tumors. In addition, whole-exome sequencing analysis revealed high SNVs and INDELs in lymphomas being driven by loss of Mlh1 and frequently mutated genes had a strong correlation with human leukemias. Therefore, the data suggest that age-related MMR deficiencies could lead to HSC malignancies after space radiation, and that countermeasure strategies will be required to adequately protect the astronaut population on the journey to Mars.']
miRNA signature detection and countermeasures against HZE radiation exposure for tissue degeneration-Soleus muscle
Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach our previous NASA work has shown both TGF xce xb2 signaling pathways and miRNAs have a critical impact on defining health risks with and without space irradiation. We hypothesize that circulating microRNA (miRNA) signatures are driving microvascular disease and muscle degeneration associated with accelerating aging and will be enhanced by exposure to the space environment (radiation and microgravity). We investigated this hypothesis both in vivo and in vitro and test novel antagonist therapies to these miRNA signatures as countermeasures to reduce space radiation-induced health risks. A comprehensive Systems Biology approach was used to examine the influence by high atomic number by high (H) atomic number (Z) and energy (E) (HZE) irradiation. To simulate low-dose exposure due to galactic cosmic rays (GCR) we used the ions energy and doses determined by a NASA consensus formula of 7 different ions to represent GCR (referred to as GCR sim model). To simulate high-dose radiation exposure due to solar particle events (SPE) we used an acute dose of SPE simulated beam at 1Gy which has energies ranging from 50MeV to 150MeV. C57BL/6 wild-type mice were utilized for irradiation with our established simulated microgravity model (hindlimb suspension model) and an in vitro 3D microvasculature tissue model under simulated microgravity (clinostat) conditions will also be irradiated. To expand on the circulating miRNA signature determined from our preliminary data we determined a group of conserved miRNAs which are commonly being regulated in the majority of the organs and tissues throughout the host using our established techniques. MiRNA-sequencing on serum (before IR and at time of sacrifice) liver heart and muscle tissue for all radiation groups revealed the key circulating miRNA signature (consisting of multiple miRNAs) impacting disease risk. Collectively understanding of how whole body space radiation impacts microvascular and tissue degeneration through circulating miRNAs will greatly enhance health risk prognostication and provide possible new mechanisms for protection against space radiation.
Impact of radiation dose and time since radiation exposure on host-microbe relationship
GEO Series GSE244571. Mus musculus. 38 samples. Type: Other.
Skin transcriptomics predict outcome after ionizing radiation exposure with potential dosimetric applications in a mouse model
GEO Series GSE185149. Mus musculus. 82 samples. Type: Expression profiling by array.
Induced torpor as a countermeasure for low dose radiation exposure in a zebrafish model
GEO Series GSE169522. Danio rerio. 11 samples. Type: Expression profiling by high throughput sequencing.
Early transcriptional changes in response to low dose radiation exposure
GEO Series GSE63952. Homo sapiens. 100 samples. Type: Expression profiling by array.
Real-time PCR array study for apoptosis genes after radiation exposure in mitochondrial mutant and normal human cells
GEO Series GSE21428. Homo sapiens. 6 samples. Type: Expression profiling by RT-PCR.
Serum miRNA-based signature to identify radiation exposure and dose in humans
GEO Series GSE174705. Homo sapiens. 71 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Rat mammary cancer induced by radiation exposure at 1, 3, or 7 weeks of age
GEO Series GSE263583. Rattus norvegicus. 24 samples. Type: Expression profiling by array.
Identifying radiation exposure biomarkers from mouse blood transcriptome
GEO Series GSE33172. Mus musculus. 18 samples. Type: Expression profiling by array.
Exposure of radiation on mouse lung
GEO Series GSE60541. Mus musculus. 9 samples. Type: Expression profiling by array.
Therapeutic radiation exposure of the abdomen during childhood induces chronic adipose tissue dysfunction
GEO Series GSE184148. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
Drug intervention of radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation
GEO Series GSE280304. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Induced Torpor: An Experimental Model to Investigate the Effects of Chronic Low-Dose Radiation Exposure on Zebrafish Liver
GEO Series GSE200212. Danio rerio. 11 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome Analysis in Mouse Skin After Exposure to Ultraviolet Radiation from a Canopy Sunbed
GEO Series GSE245747. Mus musculus. 145 samples. Type: Expression profiling by high throughput sequencing.
Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes
GEO Series GSE79579. Homo sapiens. 18 samples. Type: Expression profiling by array.
Exposure to UV radiation: gene expression profile in Enchytraeus crypticus
GEO Series GSE69794. Enchytraeus crypticus. 9 samples. Type: Expression profiling by array.
A system biology approach reveals neuronal and muscles developmental defects after chronic exposure to ionising radiation
GEO Series GSE134634. Danio rerio. 58 samples. Type: Expression profiling by high throughput sequencing.
Effect of childhood ionizing radiation exposure and calorie restriction on NASH-like pathological disorder induction and hepatocellular carcinoma development in mouse model
GEO Series GSE176108. Mus musculus. 42 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.