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Figure 2 in Oral glutamine dipeptide or oral glutamine free amino acid reduces burned injury progression in rats
Figure 2. Graphical representation of necrosis percentage evolution obtained by photographic analysis in the burn interspace, two and seven days after injury in G1-Control, G2-Dip and G3-FreeAA. In the G3-FreeAA there was a significant reduction of necrosis between two and seven days *(P<0.05).
Figure 1 in Oral glutamine dipeptide or oral glutamine free amino acid reduces burned injury progression in rats
Figure 1. Rat comb burn model: (A) Comb metal plate; (B) Comb burn injury, with four rectangular full-thickness burn areas separated by three unburned interspaces (stasis zone); (C) rectangular burned full thickness areas just after the injury; (D) animal from treated group 7 days after injury showing interspaces (stasis zone) without necrosis.
Figure 4 in Perinatal exposure to a high-fat diet alters proopiomelanocortin, neuropeptide Y and dopaminergic receptors gene expression and the food preference in offspring adult rats
Figure 4. Body weight on the 120th offspring from mothers submitted the control diet or the high-fat diet. Values are presented as mean ± SEM using two-way ANOVA followed by the Bonferroni multiple-comparison test. *p<0,05; **p<0,005.
Figure 3 in Perinatal exposure to a high-fat diet alters proopiomelanocortin, neuropeptide Y and dopaminergic receptors gene expression and the food preference in offspring adult rats
Figure 3. Body weight on the second day life's of offspring from mothers submitted the control diet (C) or the high-fat diet (H). Values are presented as mean + SEM using Student t-test. C: n = 23; H: n = 23.
Figure 2 in Perinatal exposure to a high-fat diet alters proopiomelanocortin, neuropeptide Y and dopaminergic receptors gene expression and the food preference in offspring adult rats
Figure 2. Pomc (A) and npy (B) gene expression in the hypothalamus of offspring exposed or not to a control diet or high-fat diet during perinatal and/or postnatal period. Values are presented as mean ± SEM using two-way ANOVA followed by the Bonferroni multiplecomparison test. Level of significance: *p<0,05; "a": compared to CC, "b": compared to CH; "c": compared to HC; "d": compared to HH.
Figure 1. Drd1 in Perinatal exposure to a high-fat diet alters proopiomelanocortin, neuropeptide Y and dopaminergic receptors gene expression and the food preference in offspring adult rats
Figure 1. Drd1 (A) and drd2 (B) gene expression in the nucleus accumbens of offspring exposed or not to a control diet or high-fat diet during perinatal and/or postnatal period. Values are presented as mean ± SEM using two-way ANOVA followed by the Bonferroni multiplecomparison test. Level of significance: *p<0,05; "a": compared to CC, "b": compared to CH; "c": compared to HC; "d": compared to HH.
Figure 1 in Brodifacoum residues in fish three years after an island-wide rat eradication attempt in the tropical Pacific
Figure 1. Wake Island with the seven sampling locations marked by arrows. Site names include: 1 – Peale Lagoon Side, 2 – Ioke Beach House, 3 – Waterplant Outfall, 4 – Battery Dump Pond, 5 – Southern Runway Windsock (not sampled in this study), 6 – Old AF Beach House, 7 – Nitro Rock. Image courtesy of U.S. Air Force Civil Engineer Center.
Extended rat miRNA repertoire
<p>Generally, <em>Rattus norvegicus'</em> miRNA repertoire falls short compared to the other rodent model organism, <em>Mus musculus.</em></p> <p>To extend the miRNA catalogue in <em>Rattus norvegicus,</em> we utilized Infernal v1.1 (<a href="https://doi.org/10.1093/bioinformatics/btt509" target="_blank" rel="noopener">Nawrocki and Eddy, 2013</a>) to derive potential rat miRNA candidates starting from all available mammalian miRNA families in <a href="https://www.mirbase.org/" target="_blank" rel="noopener">miRBase</a>. We utilized MIRfix (<a href="https://doi.org/10.1093/bioinformatics/btz271" target="_blank" rel="noopener">Yazbeck et al., 2019</a>) to curate the extended miRNA datasets automatically. Subsequent manual inspection and curation of miRNA alignments resulted in a reliable and comprehensive update to the rat miRNA annotation.</p> <p>Key facts of the extended miRNA repertoire</p> <ul> <li>342 miRNA families (40 novel families)</li> <li>549 miRNA sequences (56 novel miRNAs)</li> <li> 11 corrected annotated miRNAs</li> </ul> <h3>European Nucleotide Archive</h3> <p>The 56 novel sequences not listed in miRBase before have been submitted to the European Nucleotide Archive at EMBL-EBI.<br>They are accessible with the accession numbers OZ078105 - OZ078160.<br>The sequences will be permanently available from the ENA browser at http://www.ebi.ac.uk/ena/data/view/<ACCESSION NUMBERS>.</p> <p>An overview of all sequences is given here: <a href="http://www.ebi.ac.uk/ena/data/view/OZ078105-OZ078160" target="_blank" rel="noopener">http://www.ebi.ac.uk/ena/data/view/OZ078105-OZ078160</a>.</p>
Figs 3A–F in Rat spleen in the course of Babesia submicroscopic studies microti invasion: histological and
Figs 3A–F. Splenic white pulp of rats with 21-day (A, arrows show empty spaces in nuclear membrane) and 6-month B. microti invasion (B). Swellings in rat spleen with 21-day B. microti invasion (C). Invaded erythrocytes in sinus blood vessels in rat spleen with 21-day parasitemia (D). Vacuole in macrophage of the rat spleen with 6-month B. microti invasion (E). Macrophage in red pulp of the rat spleen with 6-month B. microti invasion (F). Preparations imaging with the use of transmission electron microscopy (TEM). Abbreviations: Bm – Babesia microti merozoites, Er – erythrocytes, Hem – hemosiderin, Mf – macrophage containing digested fragments of erythrocytes and heterophagical vacuoles – HV, Tr – thrombocytes, V – vacuole containing fibrous remnants of cytoskeleton.
Figs 1A–E in Rat spleen in the course of Babesia submicroscopic studies microti invasion: histological and
Figs 1A–E. The peripheral blood smear of control rats (A) rats with 21-day B. microti invasion (B) and rats with 6-month B. microti invasion (C) (black arrows – B. microti merozoites). Preparations were stained with MGG method. The surface observations of erythrocytes invaded with B. microti showed the presence of characteristic, elongated structures under the cell membrane (D, E). Imaging in AFM. Abbreviation: Lf – lymphocyte.
Figure 2 in Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain
Figure 2. LF Chromatogram (a) and the mass spectrum of presumed (b) Hinokinin, (c) Cubebin, (d) Yatein by UPLC-MS.
Figure 3 in Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain
Figure 3. Antioxidant activities on rat's brain based on activities of lipid peroxidation inhibition (a), SOD (b) and CAT (c) activities, and NO concentration (d) of lignan-rich fraction of P.cubeba 200 mg/kg (LF-200), 400 mg/kg (LF-400), Vitamin C 200 mg/kg (Vit-C), and normal control (N). The results are present as the mean ± SEM, asignificantly different compared to the N group (p<0.01), bsignificantly different compared to the N group (p<0.05).
Figure 7 in Inflammation reduction potential of nanostructured lipid carriers encapsulated with rat's bone marrow cells' lysate
Figure 7. In-vivo Gene Expression Analysis: (A) represents apoptotic markers; BAX and Caspase-3, expression in treated nanostructured lipid carriers (T-NLC), treated bone marrow-derived mesenchymal stromal cells (BMSCs) lysate (C-I-BMSCs-L) and NLC loaded BMSCs lysate (C-I-NLC-BMSCs-L) groups as compared to normal (N) and carrageenan injected injury (C) groups (B) shows proinflammatory markers (IL-6 and IL-8) expression levels in treated C-I-BMSCs-L and treated C-I-NLC-BMSCs-L groups as compared to N and C groups (C) shows Proliferative markers (Ki-67, PCNA and TOP2A) expression in treated C-I-BMSCs-L and treated C-INLC-BMSCs-L group as compared to N and C groups. Whereas N-NS represents normal rats injected with normal saline, C-NS represents carrageenan-injected normal saline, C-I-DFS represents carrageenan-injected diclofenac sodium. Where; the* sign shows significance between untreated and treated groups while α and ss sign shows significance between carrageenan injury and other treatment groups. Where, ns is non-significant, * & α represents P<0.05, ** & ss represents P<0.001, *** & αss represents P<0.0001.
Figure 6 in Inflammation reduction potential of nanostructured lipid carriers encapsulated with rat's bone marrow cells' lysate
Figure 6. Percentage inhibition of inflammation at a time interval (hr) in carrageenan-induced rat's hind paw oedema model. The effect of different treatment groups, i.e., normal (N), normal rat paw injected with normal saline (N-NS), carrageenan injected group (C), carrageenan injected with normal saline group (C-NS), carrageenan injected with diclofenac sodium group (C-I-DFS), carrageenan injected with nanostructured lipid carriers group (C-I-NLC), carrageenan injected with bone marrow-derived mesenchymal stromal cells (BMSCs) lysate group (C-I-BMSCs-L) and Carrageenan injected with NLC loaded BMSCs lysate group (C-I-NLC-BMSCs-L); on hind paw oedema at different hours (0, 1 2, 3, 6 & 24 hours). Where; the* sign shows significance between normal and carrageenan-induced treated groups while α and ss sign shows significance between carrageenan injected and carrageenaninduced treatment groups. Where; ns is non-significant, ** & ss denotes P<0.001, *** & αss denotes P<0.0001.
Figure 4 in Inflammation reduction potential of nanostructured lipid carriers encapsulated with rat's bone marrow cells' lysate
Figure 4. (A) Expression analysis of angiogenesis marker vascular endothelial growth factor (VEGF) via immunocytochemistry; (B) Expression analysis of apoptotic marker p53 via immunocytochemistry; (C) Expression analysis of apoptotic marker p53 via immunocytochemistry. Where: Untreated (UT), H 2 O 2 injury (I-H 2 O 2), treated NLC (T-NLC), treated BMSCs lysate (T-BMSCs-L), and treated NLC loaded bone marrow-derived mesenchymal stromal cells lysate (T-NLC-BMSCs-L). Stained cells are red, and blue denotes the nuclei counterstained with 4′,6-diamidine-2′-phenylindole dihydrochloride (DAPI,) while arrows show the positive cells expressing the protein. Scale bar: 200µm.
Figure 2 in Inflammation reduction potential of nanostructured lipid carriers encapsulated with rat's bone marrow cells' lysate
Figure 2. Represents cytotoxicity analysis/percentage cell viability and standardized viability concentration (SVC) values of different treatment groups on NIH 3T3 Cells (A) Represents the percentage of NIH 3T3 cells viability treated with different concentrations of nanostructured lipid carriers (NLC), bone marrow-derived mesenchymal stromal cells lysate (BMSCs-L), and NLC loaded BMSCs lysate (NLC-BMSCs-L). N represents % age viability of normal cells that receive no treatment and no H 2O2 injury; (B) Cytotoxicity analysis of various concentrations (500µg/µL, 1mg/mL, 2mg/mL, and 3mg/mL) of BMSCs lysate (C) SVC of BMSCslysate on NIH 3T3 cells; (D) Cytotoxicity analysis of various concentrations (500µg/µL, 1mg/mL, 2mg/mL, and 3mg/mL) of NLC loaded BMSCs lysate (E) shows SVC of NLC loaded BMSCs lysate on cells. Where; ***P<0.0001, *shows significance between untreated and treated groups while α and ss sign shows significance between H 2O2 injury and other treatment groups, αss shows P<0.0001, and ns is non-significant.
Figure 1 in Inflammation reduction potential of nanostructured lipid carriers encapsulated with rat's bone marrow cells' lysate
Figure 1. (A) Scanning Electron Micrograph of NLC and (B) Scanning Electron Micrograph of NLC-BMSCs-L; (B) Characterization of nanostructured lipid carriers (NLC) loaded bone marrow-derived mesenchymal stromal cells (BMSCs) lysate via enzyme-linked immunosorbent assay (ELISA):vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) expression in NLC, BMSCs-L, and NLC loaded bone marrow-derived mesenchymal stromal cells lysate (NLC-BMSCs-L).Where; *P<0.05, **P<0.01, ***P<0.0001, ns is non-significant.
Figure 3 in Ameliorative effects of morel mushroom (Morchella esculenta) against Cadmium-induced reproductive toxicity in adult male rats
Figure 3. Photomicrograph of seminiferous tubules. (A) Control; showing compact tubules, filled lumen with spermatid, normal germ cell proliferation along epithelium; (B) Cd treated group; showing tubules with empty lumen and degenerated epithelial layer with increased interstitial space; (C) Cd+10 mg extract treated group & (D) Cd+ 20 mg extract treated group; showing minimal damage to epithelium, lumen filled with spermatid and less interstitial space; (E) 10 mg extract alone group and (F) 20 mg extract alone group; showing narrow lumen, increased epithelial height and compact tubules with less interstitial space. Magnification x40. Spermatogonia (SP), Elongated spermatids (ES), Interstitial space (IS), Epithelium (E).
Figure 5 in Ameliorative effects of morel mushroom (Morchella esculenta) against Cadmium-induced reproductive toxicity in adult male rats
Figure 5. Mean ± SEM of plasma testosterone (ng/ml) concentration in rats of control, Cadmium, Cd + 10 mg of extract, Cd +20 mg extract, 10 mg extract and 20 mg extract group. (All values are expressed as Mean ± SEM) (*= P<0.05, ** P<0.01, *** P <0.001, a=control, b= Cadmium, c= Cd+10 mg extract).
Figure 4 in Ameliorative effects of morel mushroom (Morchella esculenta) against Cadmium-induced reproductive toxicity in adult male rats
Figure 4. photomicrograph of cross section of epididymis (cauda) of rats (H&E, 40X) from: (A) Control group; showing normal morphology of cauda epididymis showing compactly arranged tubules with thick epithelium, lumen filled with sperm; (B) Cadmium group; showing marked changes in structure of tubule with decreased concentration of sperm; (C) Cd+10 mg extract group & (D) Cd+ 20 mg extract group; showing regular arrangement of tubules surrounded by stroma, lumen filled with spermatozoa; (E) 10 mg extract alone group and (F) 20 mg extract alone group; showing increase in epithelium an lumen sperm concentration. Spermatozoa (S), Epithelium (E), Stroma (St). G, H and I summarizes the variations in tubule and lumen diameter and height of epithelium.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.