Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
71
datasets available to search
ShareScore release 0.9.0
Dataset results
71 results for “simulated microgravity”
Impact of simulated microgravity on the growth and proteomic profile of Enterobacter cloacae
The proteomics experiment involved analyzing the protein expression profiles of Enterobacter cloacae under different gravity conditions simulated in High Aspect Ratio Vessels (HARVs). The three conditions studied were normal gravity (NG), inverted normal gravity (INV), and low shear modeled microgravity (LSMMG). The goal was to assess how E. cloacae adapts to microgravity, given its relevance to astronaut health during spaceflight. By comparing the proteomic profiles across these conditions, the study identified significant changes in protein expression in LSMMG and INV compared to NG.
Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model
While it has been shown that astronauts suffer immune disorders after spaceflight, the underlying causes are still poorly understood and there are many variables to consider when investigating the immune system in a complex environment. Additionally, there is growing evidence that suggests that not only is the immune system being altered, but the pathogens that infect the host are significantly influenced by spaceflight and ground-based spaceflight conditions. In this study, we demonstrate that Serratia marcescens (strain Db11) was significantly more lethal to Drosophila melanogaster after growth on the International Space Station than ground-based controls, but that the host immune system is not significantly altered amongst known immune genes. High-throughput sequencing of wild-type (w1118) adult hosts infected with either space or ground-reared S. marcescens revealed few changes in gene expression, with 11 genes significantly differentially expressed (q-values less than 0.05) and only one gene related to the immune system. This data supports the main findings of the paper, which state that both spaceflight and low-shear modeled microgravity conditions increase the virulence of this pathogen, independent of the host immune system. This data, which shows that there are no significant immune-related changes to the host when infected with space-grown sample compared to ground-grown sample, provides further evidence that there are likely phenotypic changes to the pathogen itself that is causing increased virulence in spaceflight and in low-shear modeled microgravity. RNA was extracted in triplicate from 2 pooled adult (2-3 day old female) Drosophila melanogaster (w1118) per treatment, with 4 total treatment groups (no injection control, sham injection with PBS, ground bacteria-injected, and space bacteria-injected) with poly(A)+ RNA libraries. Samples were multiplexed and sequenced 100bp paired-end ready were sequenced on one lane of the Illumina HiSeq-4000.
Morphological differentiation and secondary metabolism responses of Streptomyces coelicolor A3(2) to simulated microgravity based on comparative transcriptomics (2-color)
GEO Series GSE53749. Streptomyces coelicolor A3(2). 1 samples. Type: Expression profiling by array.
Changes in nuclear shape and gene expression in response to simulated microgravity are LINC complex-dependent
GEO Series GSE153893. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile at of motor neurons under simulated microgravity (SMG) and normal gravity(NG)
GEO Series GSE226395. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Morphological differentiation and secondary metabolism responses of Streptomyces coelicolor A3(2) to simulated microgravity based on comparative transcriptomics.
GEO Series GSE53748. Streptomyces coelicolor A3(2). 6 samples. Type: Expression profiling by array.
Soleus response to simulated microgravity
GEO Series GSE52057. Rattus norvegicus; synthetic construct. 6 samples. Type: Non-coding RNA profiling by array; Expression profiling by array.
Hi-C of motor neurons under simulated microgravity (SMG) and normal gravity (NG)
GEO Series GSE226660. Homo sapiens. 2 samples. Type: Other.
miRNAs expression of soleus response to simulated microgravity
GEO Series GSE52055. Rattus norvegicus; synthetic construct. 3 samples. Type: Non-coding RNA profiling by array.
Gene expression of soleus response to simulated microgravity
GEO Series GSE52056. Rattus norvegicus. 3 samples. Type: Expression profiling by array.
Melatonin ameliorates simulated-microgravity-induced mitochondrial dysfunction and lipid metabolism dysregulation in hepatocytes
GEO Series GSE228604. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.