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ShareScore release 0.9.0
Dataset results
93 results for “soleus”
Transcriptome analysis of tenotomy immobilized rat soleus muscle
GEO Series GSE73510. Rattus norvegicus. 14 samples. Type: Expression profiling by array.
Profiling of RNA expression in soleus muscles from muscle-specific Gna13 knockout mice
GEO Series GSE83737. Mus musculus. 6 samples. Type: Expression profiling by array.
Transcriptional reprogramming during reloading of atrophied rat soleus muscle
GEO Series GSE4492. Rattus norvegicus. 23 samples. Type: Expression profiling by array.
Mouse Soleus Muscle Chronic Electrical Stimulation Study
GEO Series GSE14391. Mus musculus. 10 samples. Type: Expression profiling by array.
Microarray on mouse soleus muscles from DMP1 Cre Mbtps1 knockout mice compared with littermate controls
GEO Series GSE69985. Mus musculus. 6 samples. Type: Expression profiling by array.
Soleus muscle
GEO Series GSE1772. Mus musculus. 4 samples. Type: Expression profiling by array.
Transcriptome of reloaded soleus muscle of Tenascin-C deficient 129/SV mice
GEO Series GSE8551. Mus musculus. 6 samples. Type: Expression profiling by array.
Transcriptome analysis of rat soleus muscle after altered loading state and somatic overexpression of FAK
GEO Series GSE16466. Rattus norvegicus. 56 samples. Type: Expression profiling by array.
Transcriptome of reloaded soleus muscle of 129/SV mice
GEO Series GSE8549. Mus musculus. 6 samples. Type: Expression profiling by array.
Effect of Soleus Muscle Push Ups on Oxidative Stress and Inflammatory Markers, Soleus Endurance, and Adipocytokines Between Type 2 Diabetic, Overweight/Obese and Normal Weight Individuals.
ClinicalTrials.gov study NCT06450847. IPD Sharing: YES. Countries: 0. Publications: 0.
Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction
ClinicalTrials.gov study NCT07249645. IPD Sharing: NO. Countries: 0. Publications: 0.
Effect of Soleus Muscle Kinetic Control Training on Gait and Electromyographic Activity in Patients With Stroke
ClinicalTrials.gov study NCT07309081. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Evaluate the Role of Soleus Muscle Exercise in Glycaemic Control in Diabetic Kidney Disease Patients
ClinicalTrials.gov study NCT06120569. IPD Sharing: NO. Countries: 0. Publications: 0.
Global gene expression analysis highlights microgravity sensitive key genes in soleus and EDL of 30 days space flown mice
GEO Series GSE80223. Mus musculus. 18 samples. Type: Expression profiling by array.
5'RNA-seq analysis of soleus, tibialis anterior (TA), diaphragm and left ventricle myocardial tissue from adult wild-type mice.
GEO Series GSE75318. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Influence of Sex Hormones on Nervous System and Musculoskeletal Health in Micro and Martian Fractional Gravity in Rat Analogues (Force Plate; Soleus)
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle strength in micro- and partial-gravity environments (e.g., the Moon or Mars) is not fully understood. The purpose of this study was to determine the influence of gonadectomy (castration/ovariectomy) on progression of muscle atrophy in both micro- and partial-gravity environments in male and female rats. Male and female Fischer rats (n equals 120) underwent castration/ovariectomy (CAST/OVX) or sham surgery (SHAM) at 11 weeks of age. After 2 weeks of recovery, rats were exposed to hindlimb unloading (0g), partial weight bearing at 40% of normal loading (0.4g, Martian gravity), or normal loading (1.0g) for 28 days. In males, CAST did not exacerbate body weight loss or other metrics of musculoskeletal health. In females, OVX animals tended to have greater body weight loss and greater gastrocnemius loss. Within 7 days of exposure to either microgravity or partial gravity, females had detectable changes to estrous cycle, with greater time spent in low-estradiol phases diestrus and metestrus (∼47% in 1g vs. 58% in 0g and 72% in 0.4g animals, P equals 0.005). We conclude that in males testosterone deficiency at the initiation of unloading has little effect on the trajectory of muscle loss. In females, initial low estradiol status may result in greater musculoskeletal losses. This study derives results from Force Plate.
Global gene expression analysis highlights microgravity sensitive key genes in soleus and EDL of 30 days space flown mice
Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in physiological condition. The aim of this study was to investigate at both morphological and global gene expression level skeletal muscle adaptation to microgravity in mouse soleus and extensor digitorum longus (EDL). Adult male mice C57BL/N6 were flown aboard the BION-M1 biosatellite for 30 days on orbit (BF) or housed in a replicate flight habitat on Earth (BG) as reference flight control. In this study we investigated for the first time gene expression adaptation to 30 days of microgravity exposure in mouse soleus and EDL highlighting potential new targets for improvement of countermeasures able to ameliorate or even prevent microgravity-induced atrophy in future spaceflights. Overall Design: C57BL/N6 mice were randomly divided in 3 groups: Bion Flown (BF) mice flown aboard the Bion M1 biosatellite in microgravity environment for 30 days; Bion Ground (BG) mice housed in the same habitat of flown animals but exposed to earth gravity; and Flight Control (FC) mice housed in a standard animal facility.
Transcriptional profiling of soleus muscle from mice flown on the RR-23 mission
The objective of the Rodent Research-23 mission (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function of the arteries, veins, and lymphatic vessels that are needed to maintain vision. To this end, twenty male, C57BL/6J, 16-17 weeks-old mice were delivered to the International Space Station (ISS) on SpaceX-21 in a single transporter, transferred to two rodent habitats, and maintained in microgravity for 38 days. Flight mice were then returned to Earth alive (January 13th, 2021). After splashdown in the Atlantic Ocean, mice were transported to Kennedy Space Center via helicopter. The 20 Flight (FLT), 20 Habitat Ground Control (GC), and 20 Vivarium Ground Control (VIV) mice were removed from Rodent Transporters (FLT and GC) or vivarium cages (VIV), placed into shipping containers, and flown to Texas A and M University. There, mice underwent post-flight procedures, before euthanasia and tissue collection. FLT, GC and VIV animals were euthanized and dissected on Jan 14th, 17th or 20th of 2021, respectively. Soleus muscle samples were preserved by immersion in liquid nitrogen and stored at -80C until RNA was extracted, and libraries generated and sequenced (target 60 M clusters per sample, PE 149 bp). This dataset features 9 samples from the Flight group, 9 samples from the Habitat Ground Control group, and 9 samples from the Vivarium Ground Control group.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse soleus muscle transcriptomic and epigenomic data
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight from RR-1 and RR-9 (calcium uptake and Western blot in soleus and tibialis anterior)
It is well established that microgravity exposure causes significant muscle weakness and atrophy via muscle unloading. On Earth, muscle unloading leads to a disproportionate loss in muscle force and size with the loss in muscle force occurring at a faster rate. Although the exact mechanisms are unknown, a role for Ca2+ dysregulation has been suggested. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump actively brings cytosolic Ca2+ into the SR, eliciting muscle relaxation and maintaining low intracellular Ca2+ ([Ca2+]i). SERCA dysfunction contributes to elevations in [Ca2+]i, leading to cellular damage, and may contribute to the muscle weakness and atrophy observed with spaceflight. Here, we investigated SERCA function, SERCA regulatory protein content, and reactive oxygen/nitrogen species (RONS) protein adduction in murine skeletal muscle after 35-37 days of spaceflight. In male and female soleus muscles, spaceflight led to drastic impairments in Ca2+ uptake despite significant increases in SERCA1a protein content. We attribute this impairment to an increase in RONS production and elevated total protein tyrosine (T) nitration and cysteine (S) nitrosylation. Contrarily, in the tibialis anterior (TA), we observed an enhancement in Ca2+ uptake, which we attribute to a shift towards a faster muscle fiber type (i.e., increased myosin heavy chain IIb and SERCA1a) without elevated total protein T-nitration and S-nitrosylation. Thus, spaceflight affects SERCA function differently between the soleus and TA. This dataset derives results from the calcium uptake (spectrofluorometry) and Western blot assays.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
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