Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
122
datasets available to search
ShareScore release 0.9.0
Dataset results
122 results for “structural stability”
Data from: Influence of abiotic and biotic factors on benthic marine community composition, structure and stability: a multidisciplinary approach to molluscan assemblages from the Miocene of northern Germany
<p><span>The Miocene mica-clay deposits of Groß Pampau (northern Germany) are well known for their diverse assemblages of marine mammals, particularly whales. Despite numerous systematic and biostratigraphic studies, an in-depth palaeoecological analysis of its diverse molluscan assemblages and a comprehensive palaeoenvironmental reconstruction are lacking. Here, we integrated new faunal, sedimentological, and geochemical data to reconstruct the marine palaeo-ecosystem of the late Miocene sedimentary succession of Groß Pampau, and to identify the drivers controlling the composition, ecological structure and temporal dynamics of its macrobenthic molluscan assemblages. Fossil evidence, coupled with analyses of clay mineral composition, grain size distribution, and geochemical data (total organic carbon, total nitrogen, δ<sup>13</sup>C, δ<sup>18</sup>O, δ<sup>15</sup>N of sediment and shells), suggest a warm-temperate, mesotrophic, low-energy, offshore marine setting mostly below storm wave base and a pronounced surface-to-bottom water temperature gradient. Low variability in sedimentological and geochemical signals indicates generally stable physico-chemical conditions, whereas occurrences of opportunistic species (<em>Varicorbula</em> <em>gibba</em>) point at </span><span>occasionally less favourable bottom conditions, possibly related to transient hypoxia</span><span>. Canonical correspondence analysis reveals that the distribution of molluscan assemblages correlates with total organic carbon and nitrogen content, suggesting organic matter availability at the seafloor as a controlling factor. A pattern of repetitive punctuated stasis of molluscan assemblages is defined by the temporal persistence in taxonomic and ecological composition, occasionally interrupted by shifts to a different faunal configuration. We suggest that both stable environmental conditions and biotic interactions, i.e. the top-down control exerted by carnivorous gastropods and environmental modification by ubiquitous burrowing deposit feeders, probably contributed to the observed temporal stability. Whereas comparison with Miocene molluscan assemblages of Gram, Denmark, revealed differences in the presence and relative abundance of genera, functional congruence indicates that offshore benthic ecosystems of the southern North Sea Basin functioned similarly.</span></p>
Sluggish basal mantle structures support their long-lived stability
<p>Dataset and script for "Sluggish basal mantle structures support their long-lived stability"</p>
Initial and final MD simulation coordinates for "Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization"
<p>Initial and final coordinates for all MD simulations performed for the manuscript: "Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization."</p> <p>File uploaded is a ZIP folder, containing sub-folders for each capsid construct (wild type and mutants). Additionally, a README file is given in the top-level folder, which contains a description of the file contents.</p>
Structure-based self-supervised learning enables ultrafast prediction of stability changes upon mutation at the protein universe scale
<p>Pythia computed all single mutations of <em>E.coli</em> proteome, high quality high quality of Swiss-Prot structures and thermophilic proteins used in analysis.</p>
Fig. 4. The stability parameters for modelled D10 in In silico characterization of the impact of mutation (LEU112PRO) on the structure and function of carotenoid cleavage dioxygenase 8 in Oryza sativa
Fig. 4. The stability parameters for modelled D10 protein: wild-type (Blue), mutant (Green), Complex I (wild-type & auxin complex) (orange), Complex II (wild-type & cytokinin complex) (purple), Complex III (mutant-auxin complex) (red) and (D) Complex IV (mutant-cytokinin complex) (black) throughout 100 ns simulation: (A) RMSD, (B) RMSF, (C) PCA of C-α movement, and (D) Radius of gyration. The trajectory projected to the two-dimensional space. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Structural Stability of Carotid Plaque and Symptomatology
ClinicalTrials.gov study NCT02476396. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
Data from: Influence of abiotic and biotic factors on benthic marine community composition, structure and stability: a multidisciplinary approach to molluscan assemblages from the Miocene of northern Germany
Open the record for dataset details and reuse information.
Data from: Limited gene dispersal and spatial genetic structure as stabilizing factors in an ant-plant mutualism
Open the record for dataset details and reuse information.
Data from: Eighty-five million years of Pacific Ocean gyre ecosystem structure: long-term stability marked by punctuated change
Open the record for dataset details and reuse information.
Data from: Across-year social stability shapes network structure in wintering migrant sparrows
Open the record for dataset details and reuse information.
Data from: EB Ford revisited: assessing the long-term stability of wing-spot patterns and population genetic structure of the meadow brown butterfly on the Isles of Scilly
Open the record for dataset details and reuse information.
Data from: Climate and local environment structure asynchrony and the stability of primary production in grasslands
Open the record for dataset details and reuse information.
Data from: Ecosystem engineers shape ecological network structure and stability: a framework and literature review
Open the record for dataset details and reuse information.
A modified niche model for generating food webs with stage-structured consumers: The stabilizing effects of life-history stages on complex food webs
Open the record for dataset details and reuse information.
Changes in stream food web structure across a gradient of acid mine drainage increases local community stability
<p>Understanding what makes food webs stable has long been a goal of ecologists. Topological structure and the distribution and magnitude of interaction strengths in food webs have been shown to confer important stabilizing properties. However, our understanding of how variable species interactions affect food web structure and stability is still in its infancy. Anthropogenic stress, such as acid mine drainage, is likely to place severe limitations on the food web structures possible due to changes in community composition and body mass distributions. Here, we used mechanistic models to infer food web structure and quantify stability in streams across a gradient of acid mine drainage. Multiple food webs were iterated for each community based on species pairwise interaction probabilities, in order to incorporate the variability of realistic food web structure. We found that food web structure was altered systematically with a 32-fold decrease in the number of links and a 2-fold increase in connectance across the gradient. Stability generally increased 6-fold with increasing acid mine drainage stress, regardless of how interaction strengths were estimated. However, the distribution of the stability measure, s, for some impacted communities separated into clusters of higher and lower magnitude depending on how interaction strengths were estimated. Management and restoration of impacted sites needs to consider their increased stability, as this may have important implications for the re-colonization of desirable species. Furthermore, active species introductions may be required to overcome the internal ecological inertia of affected communities.</p>
Data from: Clonal structure through space and time: high stability in the holothurian Stichopus chloronotus (Echinodermata)
Sea cucumbers are increasingly exploited for human consumption and for their curative properties, and many wild populations are now depleted or in danger of extinction. While aquaculture is seen as an alternative to fisheries and as a mean to restore wild populations, more knowledge is needed on their reproductive strategies to render this practice efficient, notably for fissiparous holothurians, which are some of the mobile animals able of asexual reproduction by transverse fission. Little information is available on their population genetic diversity and structure. Here, the clonal structure of populations of the fissiparous sea cucumber Stichopus chloronotus has been investigated using nine microsatellite loci and a random sampling, at different spatial (intra-reef and inter-reef) and temporal (inter-season and inter-year) scales. Our findings highlight the importance of asexual reproduction in maintaining these populations, and the prevalence of the "initial seedling recruitment" strategy (ISR), leading to a high stability of clonal composition over seasons and years. It also seemed that clonal propagation was limited to the reef scale (<10 km) while reefs were connected by sexual dispersal. This is the first time that clonal structure in sea cucumbers has been studied at such a fine scale, with a specific sampling strategy. It provides key findings on the genetic diversity and structure of fissiparous sea cucumbers, which will be useful for the management of wild populations and aquaculture.
Data from: Structural modification of isomorphous SO42−-doped K2FeO4 for remediating the stability and enhancing the discharge of super-iron battery
In the paper, the isomorphous SO42- doped K2FeO4, aimed at the remediation of the discharge and stability of the super-iron battery, was first synthesized for doping and reforming the K2FeO4 crystalline structure via a facile coprecipitation and mechanochemistry. Afterward, the compared cathodes were assembled by the undoped and doped K2FeO4 for an evaluation of the discharge and stability in the AAA super-iron battery system. The results show that the small amounts of K2SO4 were doped into the K2FeO4 in the calculated form of K2Fe1-xSxO4 by the isomorphous substitution. The doped K2FeO4 cathodes/batteries exhibited an excellent discharge with a normal discharge profile. The cathodes doped by two techniques had significantly enhanced the discharge capacity of the super-iron battery with an increase of 10-30% compared to the undoped K2FeO4. Moreover, the stability of the K2FeO4 cathodes was obviously remediated by the isomorphous SO42- doping. The shelf time of the doped K2FeO4 cathodes was prolonged by an increase of about 10% in comparison of the undoped K2FeO4 cathode. The desirable enhancements could be attributed to doping and reforming the similar building block and isomorphous SO42- into the FeO42- tetrahedral and crystalline in the form of the isomorphous substitution and filling vacancies.
Data from: The Chlamydiales pangenome revisited: structural stability and functional coherence
The entire publicly available set of 37 genome sequences from the bacterial order Chlamydiales has been subjected to comparative analysis in order to reveal the salient features of this pangenome and its evolutionary history. Over 2,000 protein families are detected across multiple species, with a distribution consistent to other studied pangenomes. Of these, there are 180 protein families with multiple members, 312 families with exactly 37 members corresponding to core genes, 428 families with peripheral genes with varying taxonomic distribution and finally 1,125 smaller families. The fact that, even for smaller genomes of Chlamydiales, core genes represent over a quarter of the average protein complement, signifies a certain degree of structural stability, given the wide range of phylogenetic relationships within the group. In addition, the propagation of a corpus of manually curated annotations within the discovered core families reveals key functional properties, reflecting a coherent repertoire of cellular capabilities for Chlamydiales. We further investigate over 2,000 genes without homologs in the pangenome and discover two new protein sequence domains. Our results, supported by the genome-based phylogeny for this group, are fully consistent with previous analyses and current knowledge, and point to future research directions towards a better understanding of the structural and functional properties of Chlamydiales.
Data from: Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions
The ErbB protein tyrosine kinases are among the most important cell signaling families and mutation-induced modulation of their activity is associated with diverse functions in biological networks and human disease. We have combined molecular dynamics simulations of the ErbB kinases with the protein structure network modeling to characterize the reorganization of the residue interaction networks during conformational equilibrium changes in the normal and oncogenic forms. Structural stability and network analyses have identified local communities integrated around high centrality sites that correspond to the regulatory spine residues. This analysis has provided a quantitative insight to the mechanism of mutation-induced "superacceptor" activity in oncogenic EGFR dimers. We have found that kinase activation may be determined by allosteric interactions between modules of structurally stable residues that synchronize the dynamics in the nucleotide binding site and the αC-helix with the collective motions of the integrating αF-helix and the substrate binding site. The results of this study have pointed to a central role of the conserved His-Arg-Asp (HRD) motif in the catalytic loop and the Asp-Phe-Gly (DFG) motif as key mediators of structural stability and allosteric communications in the ErbB kinases. We have determined that residues that are indispensable for kinase regulation and catalysis often corresponded to the high centrality nodes within the protein structure network and could be distinguished by their unique network signatures. The optimal communication pathways are also controlled by these nodes and may ensure efficient allosteric signaling in the functional kinase state. Structure-based network analysis has quantified subtle effects of ATP binding on conformational dynamics and stability of the EGFR structures. Consistent with the NMR studies, we have found that nucleotide-induced modulation of the residue interaction networks is not limited to the ATP site, and may enhance allosteric cooperativity with the substrate binding region by increasing communication capabilities of mediating residues.
Data from: miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5′ UTR RNA to stabilize and promote viral RNA accumulation
Annealing of the liver-specific microRNA, miR-122, to the Hepatitis C virus (HCV) 5′ UTR is required for efficient virus replication. By using siRNAs to pressure escape mutations, 30 replication-competent HCV genomes having nucleotide changes in the conserved 5′ untranslated region (UTR) were identified. In silico analysis predicted that miR-122 annealing induces canonical HCV genomic 5′ UTR RNA folding, and mutant 5′ UTR sequences that promoted miR-122-independent HCV replication favored the formation of the canonical RNA structure, even in the absence of miR-122. Additionally, some mutant viruses adapted to use the siRNA as a miR-122-mimic. We further demonstrate that small RNAs that anneal with perfect complementarity to the 5′ UTR stabilize and promote HCV genome accumulation. Thus, HCV genome stabilization and life-cycle promotion does not require the specific annealing pattern demonstrated for miR-122 nor 5′ end annealing or 3′ overhanging nucleotides. Replication promotion by perfect-match siRNAs was observed in Ago2 knockout cells revealing that other Ago isoforms can support HCV replication. At last, we present a model for miR-122 promotion of the HCV life cycle in which miRNA annealing to the 5′ UTR, in conjunction with any Ago isoform, modifies the 5′ UTR structure to stabilize the viral genome and promote HCV RNA accumulation.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.