Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
81
datasets available to search
ShareScore release 0.9.0
Dataset results
81 results for “sts”
STS-135 Cerebellum Transcriptomics
Mice were flown onboard STS-135 and returned to Earth for analysis. Cerebellums were collected within 3-4 hours of landing and snap frozen in liquid nitrogen. Samples were shipped to UCI Genomics High Throughput Facility for analysis.
STS-135 Liver Metabolomics
Mice were flown onboard STS-135 and returned to Earth for analysis. Livers were collected within 3-4 hours of landing and snap frozen in liquid nitrogen. Samples were shipped to Metabolon, Inc. for analysis.
Fifteen days of microgravity causes growth in calvaria of mice (STS-131)
Bone growth may occur in spaceflight as a response to skeletal unloading and head-ward fluid shifts. While unloading causes significant loss of bone mass and density in legs of animals exposed to microgravity, increased blood and interstitial fluid flows accompanying microgravity-induced fluid redistribution may elicit an opposite effect in the head. Seven 23-week-old, adult female wild-type C57BL/6 mice were randomly chosen for exposure to 15 days of microgravity on the STS-131 mission, while eight female littermates served as ground controls. Upon mission completion, all 15 murine calvariae were imaged on a micro-computed tomography scanner. A standardized rectangular volume was placed on the parietal bones of each calvaria for analyses, and three parameters were determined to measure increased parietal bone volume: bone volume (BV), average cortical thickness (Ct.Th), and tissue mineral density (TMD). Microgravity exposure caused a statistically significant increase in BV of the spaceflight (SF) group compared to that of the ground control (GC) group, the mean BV ± SD for the SF group was 1.904 ± 0.842 mm3, compared to 1.758 ± 0.122 mm3 for the GC group (p less than 0.05). Ct.Th demonstrated a trend of increase from 0.099 ± 0.006 mm in the GC group to 0.104 ± 0.005 mm in the SF group (p equals 0.12). TMD was similar between the two groups with 0.878 ± 0.029 g/cm3 for the GC group and 0.893 ± 0.028 g/cm3 for the SF group (p equals 0.31). Our results indicate that microgravity causes responsive changes in calvarial bones that do not normally bear weight. These findings suggest that fluid shifts alone accompanying microgravity may initiate bone adaptation independent of skeletal loading by tissue. This dataset was derived from the literature, and contains only grouped mCT data from the calvaria.
Candida albicans response to spaceflight (NASA STS-115) --- GSM1231690_Slide_43 API
A fully queryable REST API with JSON, XML, and CSV output as well as inline, runable examples using data from the transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight conditions.
Effects of Spaceflight on Bone Microarchitecture in the Axial and Appendicular Skeleton in Growing Ovariectomized Rats from STS-62
This study investigated the effects of a 14-day spaceflight on bone mass, density and microarchitecture in weight bearing (femur and humerus) and non-weight bearing (2nd) lumbar vertebra and calvarium) bones in the context of ovarian hormone insufficiency. 12-week-old Fisher 344 rats were ovariectomized 2 weeks before flight and randomized into one of three groups: 1) baseline (n equals 6), 2) ground control (n equals 12) or 3) spaceflight (n equals 12). Additional ground-based ovary-intact rats provided age-matched reference values at baseline (n equals 8) and landing (n equals 10). Ovariectomy resulted in bone- and bone compartment-specific deficits in cancellous bone volume fraction. Spaceflight resulted in lower cortical bone accrual in the femur but had no effect on cortical bone in the humerus or calvarium. Cancellous bone volume fraction was lower in flight animals compared to ground control animals in lumbar vertebra and distal femur metaphysis and epiphysis; significant differences were not detected in the distal humerus. Bone loss (compared to baseline controls) in the femur metaphysis was associated with lower trabecular number, whereas trabecular thickness and number were lower in the epiphysis. This dataset is only for the ovariectomized animals. In summary, the effect of spaceflight on bone microarchitecture in ovariectomized rats was bone-and bone compartment-specific but not strictly related to weight bearing. This dataset derives results from the micro–computed tomography (mCT) assay.
S E- GEOD-50881 Study Samples --- Candida albicans response to spaceflight (NASA STS-115) API
A fully queryable REST API with JSON, XML, and CSV output as well as inline, runable examples using data from the transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight conditions.
Spaceflight-induced (STS-62) vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation
There is often a reciprocal relationship between bone marrow adipocytes and osteoblasts, suggesting that marrow adipose tissue (MAT) antagonizes osteoblast differentiation. MAT is increased in rodents during spaceflight but a causal relationship between MAT and bone loss remains unclear. In the present study, we evaluated the effects of a 14-day spaceflight on bone mass, bone resorption, bone formation, and MAT in lumbar vertebrae of ovariectomized (OVX) rats. Twelve-week-old OVX Fischer 344 rats were randomly assigned to a ground control or flight group. Following flight, histological sections of the second lumbar vertebrae (n equals 11/group) were stained using a technique that allowed simultaneous quantification of cells and preflight fluorochrome label. Compared with ground controls, rats flown in space had 32% lower cancellous bone area and 306% higher MAT. The increased adiposity was due to an increase in adipocyte number (224%) and size (26%). Mineral apposition rate and osteoblast turnover were unchanged during spaceflight. In contrast, resorption of a preflight fluorochrome and osteoclast-lined bone perimeter were increased (16% and 229%, respectively). The present findings indicate that cancellous bone loss in rat lumbar vertebrae during spaceflight is accompanied by increased bone resorption and MAT but no change in bone formation. These findings do not support the hypothesis that increased MAT during spaceflight reduces osteoblast activity or lifespan. However, in the context of ovarian hormone deficiency, bone formation during spaceflight was insufficient to balance increased resorption, indicating defective coupling. The results are therefore consistent with the hypothesis that during spaceflight mesenchymal stem cells are diverted to adipocytes at the expense of forming osteoblasts. This dataset derives results from the bone histomorphometry assay.
De novo homozygous deletion of segmental KAL1 and entire STS cause Kallmann syndrome and X-linked ichthyosis in a Chinese family
GEO Series GSE58793. Homo sapiens. 1 samples. Type: Genome variation profiling by genome tiling array; Genome variation profiling by SNP array.
Candida albicans response to spaceflight (NASA STS-115)
GEO Series GSE50881. Candida albicans. 8 samples. Type: Expression profiling by array.
STS-68_SLC
STS-68 SIR-C Slant Range Product
STS-68_METADATA_GRD
Metadata for STS-68 SIR-C Ground Range Product
STS-59_GRD
STS-59 SIR-C Ground Range Product
STS-68_METADATA_SLC
Metadata for STS-68 SIR-C Slant Range Product
STS-59_SLC
STS-59 SIR-C Slant Range Product
STS-68_BROWSE_GRD
Browse for STS-68 SIR-C Ground Range Product
STS-68_GRD
STS-68 SIR-C Ground Range Product
STS-59_METADATA_SLC
Metadata for STS-59 SIR-C Slant Range Product
STS-59_BROWSE_GRD
Browse for STS-59 SIR-C Ground Range Product
STS-59_METADATA_GRD
Metadata for STS-59 SIR-C Ground Range Product
STS-68_BROWSE_SLC
Browse for STS-68 SIR-C Slant Range Product
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.