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267 results for “target of selection”
Data from: Experimental contact zones reveal causes and targets of sexual selection in hybridizing lizards
Divergence in sexually selected traits in allopatry should affect the degree and direction of hybridization. However, few studies have established the causes and targets of sexual selection during secondary contact. Common wall lizards (Podarcis muralis) from north-central Italy have highly exaggerated male sexual traits compared to populations in Western Europe. Using experimental populations, we show that this creates asymmetries in male dominance, spatial habitat use and reproductive success upon secondary contact. Hybridization occurred almost exclusively between males of the Italian lineage and females of the Western European lineage. We provide evidence to suggest stronger ongoing selection on male sexual traits within the dominant Italian lineage. However, these same characters did not predict hybridization, and hybrid matings contributed little to variance in male reproductive success. Instead, most hybrid offspring were sired by Italian males displaying phenotypes associated with lower within-lineage reproductive success. Thus, highly directional hybridization arises because some Italian males are out-competed within their own lineage but remain competitive relative to males of the other lineage. This pattern of hybridization is consistent with the direction of introgression in natural contact zones, but our data suggest that sexual selection acting through hybridization may be weak at the leading edge of natural hybrid zones.
Data from: Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.
IF and SCRINSHOT image data of probe set selection for targeted spatial transcriptomics
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A review of endangered wildlife hosts in Europe for selected pathogens to be targeted by One Health surveillance
<p>EFSA has been asked by the EU-Commission to assess the prioritization of cross-border pathogens that threaten the Union to be used in setting up a coordinated surveillance system under the One Health (OH) approach. A list of 50 pathogen has been considered in a first stage by the OH Working Group of EFSA. Under this OH approach, the criteria to be applied for prioritization of pathogens in further steps should consider that emerging infectious diseases have arisen from or been identified in wildlife, with health implications for humans, domestic animals, and wildlife. The identified infectious diseases pose a threat to wildlife populations and biodiversity and are perceived by the society as real risks to wildlife conservation. We elaborated a list of potential endangered wildlife hosts distributed in Europe for each pathogen. Hosts species were classified as Near Threatened (NT), Vulnerable (BVU), Endangered (EN) and Critically Endangered (CE) based on the International Union for Conservation of Nature's (IUCN) Red List of Threatened Species. Their endemicity status was also indicated. To consider a species as potential hosts, a literature review was performed in PubMED and diagnosis included direct detection of pathogen and immunological response. A complete table and data sources are presented in excel</p>
Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.
<p><strong>This folder contains all raw data underlying the results presented in a manuscript, accepted for publication in Scientifc Reports, entitled:</strong></p> <p><strong>Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.</strong></p> <p><strong>Authored by:</strong></p> <p>Elin Sandberg <sup>1</sup>, Chinmaya V Srambickal <sup>1</sup>, Joachim Piguet <sup>1</sup>, Haichun Liu <sup>1</sup> and Jerker Widengren <sup>1,</sup>*</p> <p><sup>1</sup> Experimental Biomolecular Physics, Department of Applied Physics, Royal Institute of Technology (KTH), Stockholm, Sweden</p> <p><sup>* </sup>To whom correspondence should be addressed. Email: jwideng@kth.se. Tel: +46-8-7907813</p> <p> </p> <p><strong>The data files are grouped with respect to the figures/tables in the manuscript where the extracted results are presented. </strong></p> <p><strong>ABSTRACT</strong></p> <p>Photodynamic therapy (PDT) fundamentally relies on local generation of PDT precursor states in added photosensitizers (PS), particularly triplet and photo-radical states. Monitoring these states <em>in situ</em> can provide important feedback but is difficult in practice. The states are strongly influenced by local oxygenation, pH and redox conditions, often varying significantly at PDT treatment sites. To overcome this problem, we followed local PDT precursor state populations of PS compounds, via their fluorescence intensity response to systematically varied excitation light modulation. Thereby, we could demonstrate local monitoring of PDT precursor states of methylene blue (MB) and IRdye700DX (IR700), and determined their transitions rates under different oxygenation, pH and redox conditions. By fiber-optics, using one fiber for both excitation and fluorescence detection, the triplet and photo-radical state kinetics of locally applied MB and IR700 could then be monitored in a tissue sample. Finally, potassium iodide and ascorbate were added as possible PDT adjuvants, enhancing intersystem crossing and photoreduction, respectively, and their effects on the PDT precursor states of MB and IR700 could be locally monitored. Taken together, the presented procedure overcomes current methodological limitations and can offer feedback, guiding both excitation and PDT adjuvant application, and thereby more efficient and targeted PDT treatments.</p>
Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations
ClinicalTrials.gov study NCT02795156. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of Highly Selective Androgen Receptor (AR) Targeted Therapy in Men With Biochemically Relapsed Hormone Sensitive Prostate Cancer
ClinicalTrials.gov study NCT01790126. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Experimental contact zones reveal causes and targets of sexual selection in hybridizing lizards
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Selection and exploitation of prevalent, tandemly repeated genomic targets for improved real-time PCR-based detection of Wuchereria bancrofti and Plasmodium falciparum in mosquitoes
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Data from: Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
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Data from: Towards a mechanistic understanding of vulnerability to hook-and-line fishing: boldness as the basic target of angling-induced selection
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Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by activating a shunt pathway that generates the toxic metabolite 24(S),25-epoxycholesterol
GEO Series GSE222971. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Phosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (ChIP-seq)
GEO Series GSE21939. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription
GEO Series GSE151699. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Selective therapeutic targeting of the first and second bromodomains of the BET proteins in cancer and immuno-inflammation
GEO Series GSE138210. Homo sapiens. 161 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and controls RNA polymerase pause release at select gene targets [RNA-Seq]
GEO Series GSE183297. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Selectively targeting bromodomain and extraterminal proteins for degradation as a novel anti-glioblastoma strategy NA-seq (time course) May 15, 2018 approved TSV
GEO Series GSE99183. Homo sapiens. 49 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Pharmacological Targeting of RIG-I Selectively Activates the Integrated Stress Response
GEO Series GSE254965. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
p300 catalytic inhibition selectively targets IRF4 oncogenic activity in multiple myeloma (MM1S_ChIP_KB528)
GEO Series GSE274593. Homo sapiens. 44 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Pervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [RNA-Seq]
GEO Series GSE63467. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.