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28,650 results for “trial”
ACF database on the B12 vitamin outcomes from the MANGO trial
<p>This dataset contains the variables used in the analysis of the B12 vitamin outcomes of the MANGO trial carried out in Burkina Faso between 2016 and 2018.</p>
Grass Yield Compilation from University of Wisconsin Extension Grass Variety Trials (1983-2016)
Beginning in 1983, the UW Madison Extension has been conducting yield trials of grass varieties annually to be published in UW Extension Publication A1525. These trials are conducted at several research stations in the state of Wisconsin: Arlington, Lancaster, Marshfield and Spooner Agricultural Stations. Yield is collected for each grass variety at each cutting. The work was started by Dr. Michael Casler and was continued by Dr. Daniel Undersander. In this data set, the individual grass varieties have been aggregated to species level. Yield is recorded as the average annual total for each species at each location planted in a given year, in tons/acre. Grass species included are: bluegrass (Poa pratensis L.), festulolium (Festulolium braunii K.A.), Italian ryegrass (Lolium multiflorum Lam.), meadow bromegrass (Bromus riparius Rehmann), meadow fescue [Schedonorus pratensis (Huds.) P. Beauv], orchardgrass (Dactylis glomerata L.), perennial ryegrass (Lolium perenne L.), quackgrass (Elymus repens L.), reed canarygrass (Phalaris arundinacea L.), smooth bromegrass (Bromus inermis Leyss.), tall fescue [Lolium arundinaceum (Schreb.) Darbysh], and timothy (Phleum pratense L.).
Hubbard Brook Experimental Forest: Gastropod lichen feeding trials
Herbivory by terrestrial gastropods, particularly Arion sp., can alter lichen communities; however, little is known about this interaction in forests of North America. This data set reports the results of two feeding trials with slugs and snails from Hubbard Brook on seven lichen species. In feeding trials two common lichens, Hypogymnia physodes and Platismatia glauca, were grazed more heavily by both native and non-native slugs than other lichen species.
JST01 Juniperus virginiana seedling trial with and without bison at Konza Prairie
We report the results of a 30-year experiment at Konza Prairie, a mesic grassland in the Central Great Plains, under fire suppression (20-year fire return intervals) and experimental presence/absence of bison. Based on remote sensing, the land cover of deciduous trees was lower (6% grazed vs. 16% ungrazed) in bison-grazed areas. There was no difference between shrub land cover (42% grazed and 41%) and herbaceous land cover was higher in the grazed vs the ungrazed (51% grazed and 40% ungrazed). The land cover of evergreen trees (Juniperus virginiana L.)—which disproportionately decreases native biodiversity and increases wildfire risk—was approximately 0% with bison compared to 4% without bison. In a seedling trial of J. virginiana L., we found eight times greater over-winter mortality in the bison treatment. Juniperus virginina seedlings were transplanted with and without bison to compare mortality rates.
MiRoR4_P1_A systematic review describes models for recruitment prediction at the design stage of a clinical trial
<p>This dataset is related to the publication "A systematic review describes models for recruitment prediction at the design stage of a clinical trial".</p>
Dataset for publication: Validation of large-volume batch solar reactors for the treatment of rainwater in field trials in sub-Saharan Africa, Reyneke et al. (2020). DOI: 10.1016/j.scitotenv.2020.137223
<p>Datasets, Supplementary Information and Water Safety Plan (Assessment Form and Risk Matrix) for the publication: "Validation of large-volume batch solar reactors for the treatment of rainwater in field trials in sub-Saharan Africa" which was published in Science of the Total Environment (https://doi.org/10.1016/j.scitotenv.2020.137223).</p>
Cluster randomized controlled trial evaluating the impact on children's linear growth of an unconditional cash transfer program implemented in rural areas of North Togo
<p>A parallel cluster randomized controlled trial was implemented in North Togo. 162 rural landlocked villages were randomized into either an intervention arm (cash transfers + package of community activities, <em>n</em>=82) or a control arm (package of community activities only, <em>n</em>=80). </p> <p>Two different representative samples of children aged 6-29 months and their mothers were surveyed, one before the intervention (2014, <em>n</em>=2,658), the other two years afterwards (2016, <em>n</em>=2,031).</p> <p>You will found here:</p> <ul> <li>Two datasets, fully anonymized (French, CSV files): one for observations on households and the other for observations on mother-child pairs</li> <li>Two dictionaries of variables (French, Excel files): one for the household database and the other for the mother-child pairs database</li> <li>The study protocol as submitted to the Ministry of Health of Togo (French, PDF)</li> <li>The technical and financial proposal (to evaluate the CT program) as submitted to funders (English, PDF)</li> </ul> <p> </p>
DATASET OF "Impact of short-acting vs. standard anaesthetic agents on obstructive sleep apnoea: a randomised, controlled, triple-blind trial"
<p>Sleep apnoea is associated with negative outcomes following general anaesthesia. Current recommendations suggest using short-acting anaesthetic agents in preference to standard agents to reduce this risk, but there is currently no evidence to support this. This randomised controlled triple-blind trial tested the hypothesis that a combination of short-acting agents (desflurane-remifentanil) would reduce the postoperative impact of general anaesthesia on sleep apnoea severity compared with standard agents (sevoflurane-fentanyl). Sixty patients undergoing hip arthroplasty under general anaesthesia were randomised to anaesthesia with desflurane-remifentanil or sevoflurane-fentanyl. Respiratory polygraphy was performed before surgery and on the first and third postoperative nights. The primary outcome was the supine apnoea-hypopnoea index on the first postoperative night. Secondary outcomes were the supine apnoea-hypopnoea index on the third postoperative night, and the oxygen desaturation index on the first and third postoperative nights. Additional outcomes included intravenous morphine equivalent consumption and pain scores on postoperative days 1, 2 and 3. Pre-operative sleep study data were similar between groups. Mean (95%CI) values for the supine apnoea-hypopnoea index on the first postoperative night were 18.9 (12.7–25.0) and 21.4 (14.2–28.7) events.h<sup>-1</sup>, respectively, in the short-acting and standard anaesthesia groups (p=0.64). Corresponding values on the third postoperative night were 28.1 (15.8–40.3) and 38.0 (18.3–57.6) events.h<sup>-1</sup> (p=0.34). Secondary sleep- and pain-related outcomes were generally similar in the two groups. In conclusion, short-acting anaesthetic agents did not reduce the impact of general anaesthesia on sleep apnoea severity compared with standard agents. These data should prompt an update of current recommendations.</p>
ACF database on the predictors of time to recovery and non-response to SAM treatment in the MANGO trial
<p>This database contains the variables used to analyse the predictors of time to recovery and non-response to treatment of SAM in Burkina Faso. These results are have been submitted to review in Plos One in November 2020.</p>
Publication rate and consistency of registered trials of motor-based stroke rehabilitation
<p><strong>Table e1 - Eligible records</strong></p> <p>A list of registered randomized controlled trials (RCTs) meeting the following criteria:</p> <ol> <li>RCTs of motor-based interventions in individuals with stroke (including transient ischemic attack);</li> <li>Started on or after 1 July 2005;</li> <li>Completed before 1 April 2017 (actual or expected end date);</li> <li>Included human adult participants (≥18 years old);</li> <li>Included at least one outcome (primary or secondary) related to motor control, mobility, or physical functioning and performance of upper and/or lower extremities or the body as a whole; and</li> <li>Registered in English.</li> </ol> <p>This list was obtained by searching the following registries between 23 November 2017 and 22 February 2018: the International Clinical Trials Registry Platform, Clinicaltrials.gov (USA), Australian New Zealand Clinical Trial Registry, Chinese Clinical Trial Registry, Clinical Research Information Service (Republic of Korea), Clinical Trial Registry of India, Cuban Public Registry of Clinical Trials, European Union Clinical Trials Register, German Clinical Trials Register, Iranian Registry of Clinical Trials, International Standard Randomised Controlled Trials Number registry (UK), Center for Clinical Trials-Japan Medical Association, University Hospital Medical Information Network-Clinical Trial Registry (Japan), Thai Clinical Trials Registry, Netherlands Trials Registry, Pan African Clinical Trials Registry, Peruvian Clinical Trials Registry, and Sri Lanka Clinical Trials Registry. </p> <p><em>Variable definitions</em></p> <p>UIN: Unified identification number (obtained from the trial registry)</p> <p>Status: whether or not a peer-reviewed publication reporting the trial findings for the primary outcome/outcome was found</p> <ul> <li>Paper available: a publication reporting the trial findings for the primary outcome/objective was found</li> <li>Paper available (not English): a publication, published in a language other than English, reporting the trial findings for the primary outcome/objective was found</li> <li>Secondary paper available: a publication reporting study findings is available, but not for the primary objectives/outcome</li> <li>Results available: trial findings for the primary objective/outcome are available in a non-peer reviewed format (e.g., conference publication, non-peer reviewed journal, or uploaded to the trial registry)</li> <li>Discontinued: the trial registry record indicates that the trial was discontinued, so no publication is expected</li> <li>No paper/results: none of the above apply</li> </ul> <p>Source: database or method we used to find the publication reporting the trial findings for the primary objective/outcome</p> <ul> <li>Pubmed: the publication was found by searching for the UIN in Pubmed</li> <li>EMBASE/OVID: the publication was found by searching for the UIN in Embase or OVID Medline</li> <li>Google Scholar: the publication was found by searching for the UIN in Google Scholar</li> <li>Registry: the publication was listed in the trial registry</li> <li>Internet: the publication was found by a superficial internet search for the UIN</li> <li>Protocol: the publication was found through a cited reference search for the published protocol</li> <li>Author: the publication was found by contacting the trial investigators</li> <li>Other: the publication was found by some other means</li> <li>None: no publication reporting the trial findings for the primary objective/outcome was found</li> </ul> <p><strong>Table e2 - Published papers consistency</strong></p> <p>The subset of trials from Table e1 where an English-language publication reporting the trial findings for the primary objective/outcome was found.</p> <p><em>Variable definitions</em></p> <p>UIN: Unified identification number (obtained from the trial registry)</p> <p>DOI: digital objective identifier of the publication</p> <p>First_author: last name of the first author of the publication</p> <p>Year: year of the publication</p> <p>Journal: journal of the publication (abbreviated journal names are used, where available)</p> <p>Reg_Trial_End_Date: end date of the trial, as stated in the trial registry (format DD-MMM-YY)</p> <p>Date_Submitted: date when the paper was submitted to the journal for publication (where available; format: DD-MMM-YY)</p> <p>Time_To_Submit: difference, in days, between Reg_Trial_End_Date and Date_Submitted</p> <p>Date_Published: date when the paper was published, either online or in print, whichever is earlier (format: DD-MMM-YY)</p> <p>Time_To_Publish: difference, in days, between Reg_Trial_End_Date and Time_To_Publish</p> <p>UIN_Paper_Location: location of the UIN in the publication</p> <p>Reg_Pilot: whether the trial was defined as a pilot or feasibility study in the registry record (0=no, 1=yes)</p> <p>Paper_Pilot: whether the trial was defined as a pilot or feasibility study in the publication (0=no, 1=yes)</p> <p>Consistency_pilot: whether Reg_Pilot = Paper_Pilot (0=no, 1=yes)</p> <p>Consistency_Primary_Objective: whether the trial registry record and publication were consistent in terms of the primary objective (0=no, 1=yes)</p> <p>Consistency_Primary_Outcome: whether the trial registry record and publication were consistent in terms of the primary outcome (0=no, 1=yes)</p> <p>Target_N: target sample size, as indicated in the trial registry record</p> <p>Paper_N: number of participants recruited to the study, as indicated in the publication</p> <p>Consistency_N: whether the trial registry record and publication were consistent in terms of the sample size (i.e., Paper_N is within +/-10% of Target_N; 0=no, 1=yes)</p> <p>N_direction: for those trials that were inconsistent in terms of the sample size, whether Paper_N was less than (Under) or more then (Over) Target_N</p> <p>Eligibility_Consistency: whether the trial registry record and publication were consistent in terms of the eligibility criteria</p> <p>UIN_in_paper: the UIN that was included in the paper, exactly as it was published</p> <p>UIN_consistency: whether UIN = UIN_in_paper (0=no, 1=yes)</p> <p>Reg_Type: whether the trial was registered before recruiting the first participant (Prospective), after recruiting the first participant but before the trial was completed (Retro - pre-completion), or after the trial was completed (Retro - post-completion)</p> <p><strong>Table e3 - Inconsistency details</strong></p> <p>The subset of trials from Table e2 where the trial registry record and publication were inconsistent on only one of the criteria examined. This table provides further details of these inconsistencies, and details of any explanations for changes to the protocol since registration, if available.</p>
Time series of epileptic seizures in a 8yo male on a cannabidiol trial
<p>Time series of epileptic seizures in a 8yo male with idiopathic catastrophic epilepsy (probably of mitochondrial origin) in a cannabidiol (CBD) trial.</p> <p>The data are of <strong>observed seizures </strong>during each day by the patient's parents and caregivers and thus are not exact values for total daily seizure activity; the values in this dataset are best considered a lower bound. However, observation effort was essentially constant over the time series, so the data likely reflect overall trends even though precise daily seizure counts are not available.</p> <p>The time series includes a 21-day baseline period and a 36-day trial period. The CBD was administered via g-tube in an olive oil base. Dosage was approximately 7.5 mg/kg/day for two weeks, and approximately 8 mg/kg/day for three weeks.</p> <p>Each 1ml of oil contained 10.00mg of total CBD and 0.42mg of total THC, for a CBD:THC ratio of approximately 20:1 (analysis by HPLC).</p> <p><strong><em>Data Dictionary</em></strong></p> <ul> <li><strong>Date</strong>: YYYY-MM-DD</li> <li><strong>Tonic</strong>: tonic seizure count (http://www.epilepsy.com/learn/types-seizures/tonic-seizures)</li> <li><strong>Tonic-Clonic</strong>: tonic-clonic (aka "grand mal") seizure count (http://www.epilepsy.com/learn/types-seizures/tonic-clonic-seizures)</li> <li><strong>Spasms</strong>: myoclonic seizure count (http://www.epilepsy.com/learn/types-seizures/myoclonic-seizures)</li> <li><strong>Total</strong>: total number of seizures (sum of above)</li> <li><strong>Notes</strong>: notes by parents</li> </ul>
PsPM-SCRV2: Skin conductance responses to loud sounds at different inter trial intervals.
<p>This dataset includes skin conductance response (SCR) measurements, keypress responses and keypress response times to acoustic stimuli for each of 24 healthy unmedicated participants (12 males and 12 females aged 24+/-4.6 years, identical sample as in SCRV_1). The stimuli are 1s long white noise bursts at 95dB presented over headphones. Mean ISI is varied in a block-wise fashion (3s, 9s, 19s). The experiment follows a single factorial design with three levels of the mean ISI.</p>
PsPM-SCRV1: Skin conductance responses to aversive/neutral pictures at different inter trial intervals.
<p>This dataset includes skin conductance response (SCR) measurement, keypress responses and keypress response times to stimuli drawn from the International Affective Picture System for each of 24 healthy unmedicated participants (12 males and 12 females aged 27+/-4.6 years). The experiment used a 2x3 factorial design with the factors picture type (aversive, neutral), and mean ISI (3s, 9s, and 19s).</p> <p>Data are untrimmed. The referenced article used a trimmed version of the data (trim points: 0.5 s before first marker until 20 s after last marker). This detail is not mentioned in the methods section of the paper. </p> <p>See the readme file for more detail. Data are stored as .mat files for use with MATLAB in a format readable by the PsPM toolbox (pspm.sourceforge.net).</p> <p> </p> <p> </p>
Oviposition trials of Euphydryas phaeton on Plantago lanceolata
<p>Understanding the circumstances under which insect herbivores will adopt a novel host plant is a longstanding question in basic and applied ecology. Though there has been ample study of regional differences in host preference across numerous insect herbivores, the extent to which intraspecific variation in plant species shape these patterns is relatively less well known. In parts of its range the Baltimore checkerspot<em> Euphydryas phaeton</em> uses English plantain <em>Plantago lanceolata</em>, a novel host plant, in addition to its native host, White turtlehead <em>Chelone galbra</em>. We offered female butterflies from each region the non-native host lpant sourced from both regions and compared their oviposition behavior. The non-native host was near universally rejected by butterflies in the region where only the native plant is used. In the region where both hosts are used, plants from that same region were preferred relative to plants from the other region. This suggests that regional variation in host plant use by an insect depends on intraspecific variation in both species in the interaction.</p>
Nordic trial reporting project: Raw data from EU Clinical Trials Registry (EUCTR) and ClinicalTrials.gov
<p>Uploaded on behalf of the author team for the research project "<strong>Systematic evaluation of clinical trial reporting at medical universities and university hospitals in the Nordic countries</strong>".</p><p><strong>Raw data</strong> from EU Clinical Trials Registry (EUCTR) and ClinicalTrials.gov:</p><p><strong>EUCTR</strong>: We retrieved the latest dataset for the EU Trials Tracker of EUCTR trials on Nov 27, 2022, reflecting data from Nov 7, 2022 (1,2). We also used a custom web scraper that automatically extracts data from EUCTR country protocols and results sections (variables described in Appendix Table 2), developed by the EU Trials Tracker team (2).<br>References: <br>1. Goldacre B, DeVito NJ, Heneghan C, Irving F, Bacon S, Fleminger J, Curtis H. Compliance with requirement to report results on the EU Clinical Trials Register: cohort study and web resource. BMJ. 2018 Sep 12;362:k3218.<br>2. EU Trials Tracker — Who's not sharing clinical trial results? [Internet]. [cited 2022 Aug 30]. Available from: http://eu.trialstracker.net/</p><p><strong>ClinicalTrials.gov</strong>: We downloaded the complete Aggregate Analysis of ClinicalTrials.gov dataset (AACT, http://aact.ctti-clinicaltrials.org/) on Nov 27, 2022, reflecting data from Nov 9, 2022. </p><p>See our GitHub and preregistered protocol for more details:<br>https://github.com/cathrineaxfors/nordic-trial-reporting<br>https://osf.io/97qkv/</p>
The Mexican dataset of an rTMS clinical trial on cocaine use disorder patients: SUDMEX TMS
<p>The SUDMEX_TMS dataset is the result of a longitudinal clinical trial of cocaine use disorder patients that were treated with rTMS at 5-Hz on the left dorsolateral prefrontal cortex (lDLPFC) for a 2 week double-blind acute phase and an open-label maintenance phase that included clinical, cognitive and MRI data acquisition. The design was a double-blind placebo-controlled randomized controlled trial with parallel groups (acute phase). The study was done at the National Institute of Psychiatry .</p> <p>Each patient had more than one clinical and MRI session or time point from baseline (T0), 2 weeks (T1), 3 months (T2), 6 months (T3) and some patients had 12 months (T4). The T14 time point was only for patients in the Sham group who decided to continue the clinical trial with open-label rTMS. The T14 refers to 2 weeks after T1 (4 weeks after T0).</p> <p>The MRI sequences were: 1) T1-weighted, 2) rsfMRI 10 min, 3) HARDI-DWI multishell (next release).</p> <p>The data set is curated and organized by test and item for each experimental phase and also has a dictionary to define the variables measured.</p> <p> </p> <p>If you require more information about data or scales, please contact us. </p> <p><em>LANIREM (</em><em>National MRI Laboratory)</em><em>, Institute of Neurobiology, </em></p> <p><em>Universidad Nacional Autónoma de México (UNAM), </em><em>Querétaro, México.</em></p> <p><strong>Diego Angeles Valdez, M. Sc. </strong></p> <ul> <li>diego.ang.val@gmail.com</li> <li>diego.ang.val@inb.unam.mx</li> </ul> <p><br> <strong>Eduardo A. Garza-Villarreal, M.D., Ph.D.</strong></p> <ul> <li>egarza@gmail.com</li> <li>egarza@comunidad.unam.mx</li> </ul>
Context-dependent multimodal behaviour in a coral reef fish: Stage 1 & 2 total duration and count data in behaviour trials
<p>Animals are expected to respond flexibly to changing circumstances, with multimodal signalling providing potential plasticity in social interactions. Whilst numerous studies have documented context-dependent behavioural trade-offs in terrestrial species, far less work has considered such decision-making in fish, especially in natural conditions. Coral reef ecosystems host 25% of all known marine species, making them hotbeds of competition and predation. We conducted experiments with wild Ambon damselfish (<em>Pomacentrus amboinensis)</em> to investigate context-dependent responses to a conspecific intruder; specifically, how nest defence is influenced by an elevated predation risk. We found that nest-defending male Ambon damselfish responded aggressively to a conspecific intruder, spending less time sheltering and more time interacting, as well as signalling both visually and acoustically. In the presence of a model predator compared to a model herbivore, males spent less time interacting with the intruder, with a tendency towards reduced investment in visual displays compensated for by an increase in acoustic signalling instead. We therefore provide ecologically valid evidence that the context experienced by an individual can affect its behavioural responses and multimodal displays towards conspecific threats.</p>
Full eQTL summary statistics for the PAUSE trial
<p>This dataset contains full eQTL summary statistics for the study 'Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin' (<em>Nat.Comm., </em>2023). The study analyzes 375 skin samples from patients with psoriasis. For each SNP-gene pair, the dataset provides information listed below.</p> <ol> <li><strong>ID</strong>: the variant identifier, with chromosome number, position, ref and alt alleles.</li> <li><strong>Estimate</strong>: estimate</li> <li><strong>Std.Error</strong>: standard error</li> <li><strong>df</strong>: degrees of freedom</li> <li><strong>t value</strong>: t-value of the association</li> <li><strong>Pr(>|t|): </strong>p-value of the association</li> <li><strong>Gene: </strong>Ensembl gene ID</li> <li><strong>CHROM: </strong>the variant chromosome</li> </ol>
Common bunt in wheat: Results of the ECOBREED field trials, Austria and Czech Republic, 2021-2022
<p>Supplementary material to Lunzer et al. (2023) Front Plant Sci 14: 1264458 [https://doi.org/10.3389/fpls.2023.1264458]:</p> <ul> <li>Scheme for the marker-assisted selection for common bunt QTL</li> <li>Raw data of field and lab evaluations - Austria & Czech Republic 2021</li> <li>Raw data of field and lab evaluaitons - Austria & Czech Republic 2022</li> </ul> <p>Raw data files include the data on several spreadsheet sheets. Each file includes metadata and used abbreviations in the first two sheets.</p>
Selected articles from the scoping review of biomarker discovery studies for the EU project on "Personalised Medicine Trials" (PERMIT)
<p>This dataset provides the data extracted for the scoping review of the literature on biomarker discovery studies for patient stratification using machine learning analysis of omics data, as part of the EU project on “Personalised Medicine Trials” (PERMIT). It covers the references for all articles selected as part of the scoping review, as well as information on the study type and methodology, the outcome measures, the validation type, and representative sentences extracted from each article on the main results and key findings of the corresponding biomarker study.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.