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891
datasets available to search
ShareScore release 0.9.0
Dataset results
891 results for “Apoptosis”
LHRH Receptor Monoclonal Antibody 4F3B10 Induces Apoptosis of HeLa Cells
GEO Series GSE95695. Homo sapiens. 2 samples. Type: Expression profiling by array.
Class IIa HDACs reprogram mitochondrial metabolism to inhibit apoptosis and ferroptosis in response to lipotoxicity
GEO Series GSE215185. Mus musculus. 19 samples. Type: Expression profiling by array.
HO-1 modulates the expression of genes involved in inflammation, angiogenesis, proliferation, apoptosis and cell adhesion in human lung cancer cells.
GEO Series GSE22030. Homo sapiens. 12 samples. Type: Expression profiling by array.
Snip1 and PRC2 coordinate the intrinsic apoptosis, cell division, and neurogenesis in the developing brain [RNA-seq]
GEO Series GSE212103. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Expression profiling and function analysis identified new microRNAs regulating cumulus expansion and apoptosis in cumulus cells
GEO Series GSE189959. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Core fucosylation of IL-15 receptor delineates homeostatic proliferation and apoptosis signalling required for natural killer cell development
GEO Series GSE243190. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 and RSK inhibitiors in melanoma
GEO Series GSE264686. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NfkB-dependent differentiation of AML cells
GEO Series GSE92744. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Myeloid EGFR deficiency accelerates recovery from Aki via macrophage efferocytosis and neutrophil apoptosis
GEO Series GSE261530. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Valine induces testis apoptosis through altering autophagy and nucleic acid methylation in mouse
GEO Series GSE217966. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Blocking Host Factors IAP and DDX3 Reverse HIV-1 Latency and Restore Apoptosis Vulnerability of the HIV-1 reservoir
GEO Series GSE303821. Homo sapiens. 8 samples. Type: Expression profiling by RT-PCR.
Pterostilbene Protects Cochlea from Ototoxicity in Streptozotocin-Induced Diabetic Rats by Inhibiting Apoptosis
<p>Diabetes mellitus (DM) causes ototoxicity by inducing oxidative stress, microangiopathy, and apoptosis in the cochlear sensory hair cells. The natural anti-oxidant pterostilbene (PTS) (trans-3,5-dimethoxy-4-hydroxystylbene) has been reported to relieve oxidative stress and apoptosis in DM, but its role in diabetic-induced ototoxicity is unclear. This study aimed to investigate the effects of dose-dependent PTS on the cochlear cells of <em>streptozotocin</em> (STZ)-induced diabetic rats. The study included 30 albino male Wistar rats that were randomized into five groups: non-diabetic control (Control), diabetic control (DM), and diabetic rats treated with intraperitoneal PTS at 10, 20, or 40 mg/kg/day during the four-week experimental period (DM + PTS10, DM + PTS20, and DM + PTS40). Distortion product otoacoustic emission (DPOAE) tests were performed at the beginning and end of the study. At the end of the experimental period, apoptosis in the rat cochlea was investigated using caspase-8, cytochrome-c, and terminal deoxyribonucleotidyl transferase-mediated dUTP-biotin end labeling (TUNEL). Quantitative real-time polymerase chain reaction was used to assess the mRNA expression levels of the following genes: <em>CASP-3</em>, BCL-associated X protein (<em>BAX</em>), and<em> BCL-2</em>. Body weight, blood glucose, serum insulin, and malondialdehyde (MDA) levels in the rat groups were evaluated. The mean DPOAE amplitude in the DM group was significantly lower than the means of the other groups (0.9–8 kHz; P < 0.001 for all). A dose-dependent increase of the mean DPOAE amplitudes was observed with PTS treatment (P < 0.05 for all). The Caspase-8 and Cytochrome-c protein expressions and the number of TUNEL-positive cells in the hair cells of the Corti organs of the DM rat group were significantly higher than those of the PTS treatment and control groups (DM > DM + PTS10 > DM + PTS20 > DM + PTS40 > Control; P < 0.05 for all). PTS treatment also reduced cell apoptosis in a dose-dependent manner by increasing the mRNA expression of the anti-apoptosis <em>BCL2</em> gene and by decreasing the mRNA expressions of both the pro-apoptosis <em>BAX</em> gene and its effector <em>CASP-3</em> and the ratio of <em>BAX/BCL-2</em> in a dose-dependent manner (P < 0.05 compared to DM for all). PTS treatment significantly improved the metabolic parameters of the diabetic rats, such as body weight, blood glucose, serum insulin, and MDA levels, consistent with our other findings (P < 0.05 compared to DM for all). PTS decreased the cochlear damage caused by diabetes, as confirmed by DPOAE, biochemical, histopathological, immunohistochemical, and molecular findings. This study reports the first in vivo findings to suggest that PTS may be a protective therapeutic agent against diabetes-induced ototoxicity.</p>
Silencing of the Stat1-bcl2 axis accelerates efficient apoptosis of immature T lymphocytes with DNA damage in zebrafish mcm5 mutants
GEO Series GSE236184. Danio rerio. 6 samples. Type: Expression profiling by high throughput sequencing.
N-acetylcysteine and Vitamin C stimulate MYC binding to EGR1 and selectively stimulate apoptosis in B cell lymphoma
GEO Series GSE199843. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Apoptosis-associated transcriptome changes in peripheral blood leukocytes during HHV-6 antiviral therapy
GEO Series GSE129246. Homo sapiens. 41 samples. Type: Expression profiling by array.
Setdb1 is required for formation of pancreatic ductal adenocarcinoma by inhibiting p53-mediated apoptosis in mice
GEO Series GSE145775. Mus musculus. 6 samples. Type: Expression profiling by array.
RBM4 modulate apoptosis and expression of inflammatory factors via alternative splicing in HeLa cells
GEO Series GSE134402. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional analysis of human IL-23R mediated apoptosis in human cervical cancer cells in vitro
GEO Series GSE229036. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
In vitro infection of Bovine monocytes with Mycoplasma bovis delays apoptosis and suppresses production of IFNγ and TNF-α but not IL-10
GEO Series GSE47743. Bos taurus. 6 samples. Type: Protein profiling by protein array.
Aalpi18529 regulates vitellogenesis of Aedes albopictus via the Gadd45a-mediated JNK-dependent nurse cell apoptosis pathway [small-RNA-seq]
GEO Series GSE266103. Aedes albopictus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.