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Dataset results
2,880 results for “variant”
IDSL.CSA unique CSA variants for the ST001000 - full deconvolution
<p>IDSL.CSA unique CSA variants for the ST001000 - full deconvolution</p>
VCF of structural variant calls of Nanopore data aligned to dm6 reference genome
<p>Heterozygous chromosome inversions suppress meiotic crossover (CO) formation within an inversion, potentially because they lead to gross chromosome rearrangements that produce inviable gametes. Interestingly, COs are also severely reduced in regions nearby but outside of inversion breakpoints even though COs in these regions do not result in rearrangements. Our mechanistic understanding of why COs are suppressed outside of inversion breakpoints is limited by a lack of data on the frequency of noncrossover gene conversions (NCOGCs) in these regions. To address this critical gap, we mapped the location and frequency of rare CO and NCOGC events that occurred outside of the <em>dl</em>-<em>49</em> <em>chrX</em> inversion in <em>D</em>. <em>melanogaster</em>. We created full-sibling wildtype and inversion stocks and recovered COs and NCOGCs in the syntenic regions of both stocks, allowing us to directly compare rates and distributions of recombination events. We show that COs are completely suppressed within 500 kb of inversion breakpoints, are severely reduced within 2 Mb of an inversion breakpoint, and increase above wildtype levels 2–4 Mb from the breakpoint. We find that NCOGCs occur evenly throughout the chromosome and, importantly, occur at wild-type levels near inversion breakpoints. We propose a model in which COs are suppressed by inversion breakpoints in a distance-dependent manner through mechanisms that influence DNA double-strand break repair outcome but not double-strand break location or frequency. We suggest that subtle changes in the synaptonemal complex and chromosome pairing might lead to unstable interhomolog interactions during recombination that permits NCOGC formation but not CO formation.</p>
Supporting data for Comparison of Oxford Nanopore and Illumina sequencing for SARS-CoV-2 variant monitoring in wastewater
<p>This dataset contains the FASTQ files used in the paper <em>Comparison of Oxford Nanopore and Illumina sequencing for SARS-CoV-2 variant monitoring in wastewater</em>. </p> <p>The FASTQ files are classified in 2 different folders: MinION and MiSeq. Inside the MinION folder, there are two more folders, one for the R9.4.1 flow cell data and the other for the R10.4.1 flow cell data. </p> <p>Twist synthetic RNA mixtures are named as mix1, mix2, etc. </p> <p>Twist synthetic RNA corresponding to the Wuhan sequence is named as mix11_WH</p> <p>Wastewater samples are named as WWTP_1, WWTP_2, etc. </p>
Data files for "Comprehensive Wastewater Sequencing Reveals Community and Variant Dynamics of the Collective Human Virome"
<p>Files required to run analyses and generate charts for R notebooks at: <a href="https://github.com/cmmr/TX_wastewater_virome">https://github.com/cmmr/TX_wastewater_virome</a></p> <p> </p> <p> </p>
Dataset for the manuscript "In silico evaluation of variant calling methods for bacterial whole genome sequencing"
<p>Input data and associated analysis code for reproducing results reported in the manuscript.</p>
Contribution of genetic variants to the susceptibility of infection by Severe Acute Respiratory Syndrome to CoV-2 in a population of individuals residing in Ecuador
<p>The file presents, in the table, the genotype and alleles obtained from each subject participating in the laboratory phase that are discriminated by groups (control and case groups).<br> The allelic frequencies calculated in the Microsoft Excel program are also presented.</p>
Open-Label Study of Leuco-methylthioninium Bis(Hydromethanesulfonate) (LMTM) in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD)
ClinicalTrials.gov study NCT02245568. IPD Sharing: Not stated. Countries: 17. Publications: 0.
Hormone Replacement Therapy and Prothrombotic Variants
ClinicalTrials.gov study NCT00049933. IPD Sharing: Not stated. Countries: 0. Publications: 5.
Return of Actionable Variants Empirical Study
ClinicalTrials.gov study NCT03640234. IPD Sharing: Not stated. Countries: 0. Publications: 10.
Pathogenic Variants in Homologous Recombination Repair Genes in Patients With Epithelial Ovarian Cancer
ClinicalTrials.gov study NCT04716374. IPD Sharing: NO. Countries: 0. Publications: 1.
Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant Histology Bladder Cancer
ClinicalTrials.gov study NCT03912818. IPD Sharing: NO. Countries: 1. Publications: 0.
Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of P4M3 Variants
ClinicalTrials.gov study NCT03379740. IPD Sharing: NO. Countries: 1. Publications: 0.
Allogeneic Stem Cell Transplantation, Severe Homzygous 0/+Thalassemia or Sever Variants of Beta 0/+ Thalassemia, THALLO
ClinicalTrials.gov study NCT00578292. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gene Therapy For Children With Variant Late Infantile Neuronal Ceroid Lipofuscinosis 6 (vLINCL6) Disease
ClinicalTrials.gov study NCT02725580. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Assess the Relative Bioavailability of Process Variants of Selumetinib in Healthy Male Volunteers
ClinicalTrials.gov study NCT02322749. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized Study of Yohimbine Treatment for Type 2 Diabetes Patients Carrying a Specific Genetic Risk Variant
ClinicalTrials.gov study NCT01593215. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Variants of Paranasal Sinuses in Nepali Population
ClinicalTrials.gov study NCT06683859. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Mov
ClinicalTrials.gov study NCT05418673. IPD Sharing: YES. Countries: 6. Publications: 0.
Impact of New Variants and Vaccines on the Course of COVID-19
ClinicalTrials.gov study NCT05384886. IPD Sharing: YES. Countries: 1. Publications: 0.
Study of Coagulation Factor VIIa Variant Marzeptacog Alfa (Activated) in Adult Subjects With Hemophilia A and B
ClinicalTrials.gov study NCT03407651. IPD Sharing: NO. Countries: 5. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.