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3,430 results for “PD”
Spatial Transcriptomics data (GeoMx) of locus coeruleus dopamine cells in control and PD subjects
<p>The repository includes Spatial Transcriptomic datasets generated by Nanostring GeoMx (Hu WTA) analysis of locus coeruleus TH+ cells from Controls (n=9), early Parkinsons Disease (ePD, n=8) and late Parkinsons Disease (lPD, n=2). A total 39 Regions of Interest were analysed. The raw and processed counts and metadata are provided as an R Seurat object (geomx_vila_thmask.rds). The scripts used for low level data processing are described in https://github.com/zchatt/ASAP-SpatialTranscriptomics/blob/main/geomx/lowlevel/README.md.</p> <p>Tissue samples from pathologically confirmed stage IV Lewy body PD (early-PD), stage VI Lewy body PD (late-PD)(Braak, Del Tredici et al. 2003) and controls without the neurological or neuropathological disease were obtained from the Sydney Brain Bank. The study was approved by the University of Sydney Human Research Ethics Committee (2021/845). All cases with PD were levodopa-responsive and fulfilled the UK Brain Bank Clinical Criteria for a diagnosis of clinical PD (Hughes, Ben-Shlomo et al. 1992) with no other neurodegenerative conditions. </p> <p>Cells were not extracted. Tissue sections were cut from FFPE blocks of post-mortem human midbrains at 6µm on a rotary microtome (HistoCore MULTICUT, Leica Biosystems) and mounted on Series 2 adhesive microscope slides (Trajan Scientific Medical, AU) for processing for spatial trranscriptomics. To remove the paraffin, slides were incubated in the oven at 60°C for 1hr and then submerged in HistoChoice Clearing Agent (Sigma-Aldrich, H2779) for 2x7mins, followed by rehydration in decreasing ethanol concentrations (100% ethanol for 2x3mins, 95% ethanol for 3mins, 70% ethanol for 3mins) and distilled H2O for 3mins. </p> <p>Tissue sections were immunohistochemically stained for tyrosine hydroxylase and Regions of Interest (ROIs) processed following Nanostring GeoMx® Digital Spatial Profiler using the manufacturer’s instructions. Libraries were sequenced on Illumina Novaseq 6000 platform using NovaSeq SP 100 cycle kit (XP workflow, 27-8-8-27).</p> <p>This research was funded in whole or in part by Aligning Science Across Parkinson’s (ASAP-020505) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). For the purpose of open access, the author has applied a CC BY 4.0 public copyright license to all Author Accepted Manuscripts arising from this submission.</p>
Spatial Transcriptomics data (GeoMx) of midbrain tissue in control and PD subjects
<p>he repository includes Spatial Transcriptomic datasets generated by Nanostring GeoMx (Hu WTA) analysis of midbrain unmasked (whole tissue) Regions of Interest from Controls (n=10), Incidental Lewy Body Disease (n=11), early Parkinsons Disease (ePD, n=5) and late Parkinsons Disease (lPD, n=6). A total 515 Regions of Interest were analysed. The raw and processed counts and metadata are provided as an R Seurat object (geomx_vila_unmask.rds). The scripts used for low level data processing are described in https://github.com/zchatt/ASAP-SpatialTranscriptomics/blob/main/geomx/lowlevel/README.md </p> <p>Tissue samples from pathologically confirmed asymptomatic stage I-II Lewy body disease, stage IV Lewy body PD (early-PD), stage VI Lewy body PD (late-PD)(Braak, Del Tredici et al. 2003) and controls without the neurological or neuropathological disease were obtained from the Sydney Brain Bank. The study was approved by the University of Sydney Human Research Ethics Committee (2021/845). All cases with PD were levodopa-responsive and fulfilled the UK Brain Bank Clinical Criteria for a diagnosis of clinical PD (Hughes, Ben-Shlomo et al. 1992) with no other neurodegenerative conditions. </p> <p>Cells were not extracted. Tissue sections were cut from FFPE blocks of post-mortem human midbrains at 6µm on a rotary microtome (HistoCore MULTICUT, Leica Biosystems) and mounted on Series 2 adhesive microscope slides (Trajan Scientific Medical, AU) for processing for spatial trranscriptomics. To remove the paraffin, slides were incubated in the oven at 60°C for 1hr and then submerged in HistoChoice Clearing Agent (Sigma-Aldrich, H2779) for 2x7mins, followed by rehydration in decreasing ethanol concentrations (100% ethanol for 2x3mins, 95% ethanol for 3mins, 70% ethanol for 3mins) and distilled H2O for 3mins. </p> <p>Tissue sections were immunohistochemically stained for tyrosine hydroxylase and Regions of Interest (ROIs) processed following Nanostring GeoMx® Digital Spatial Profiler using the manufacturer’s instructions. Libraries were sequenced on Illumina Novaseq 6000 platform using NovaSeq SP 100 cycle kit (XP workflow, 27-8-8-27).</p> <p>This research was funded in whole or in part by Aligning Science Across Parkinson’s (ASAP-020505) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). For the purpose of open access, the author has applied a CC BY 4.0 public copyright license to all Author Accepted Manuscripts arising from this submission.</p>
Figures 5, 6, 7 of Perpendicularly magnetized Co_Pd-based magneto-resistive hetereostructures on flexible substrates
Open the record for dataset details and reuse information.
ESMO-GROW checklist for the publication PD-1/PD-L1 blockade plus abnobaViscum® therapy is associated with improved survival in advanced or metastasized NSCLC patients, a real-world data registry study according to the ESMO-GROW criteria
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"THE APPLICATION OF MIRAPEX PD EXTENDED-RELEASE IN MONOTHERAPY MODE IN THE EARLY STAGES OF PARKINSON'S DISEASE IN THE REPUBLIC OF UZBEKISTAN."
Open the record for dataset details and reuse information.
Figure 2 from: Zha L-S, Yu F-M, Boonmee S, Eungwanichayapant PD, Wen T-C (2017) Taxonomy of Macromotettixoides with the description of a new species (Tetrigidae, Metrodorinae). ZooKeys 645: 13-25. https://doi.org/10.3897/zookeys.645.9055
Figure 2 - Macromotettixoides parvula sp. n. a frontal view of female head b dorsal view of female head c left-lateral view of female tegmen and hind wing after uncovering the pronotum d lateral view of female head and anterior pronotum e lateral view of female ovipositor and subgenital plate f ventral view of female subgenital plate g lateral view of male subgenital plate h left-lateral view of female hind tarsus. Scale bars 0.5 mm.
Figure 3 from: Zha L-S, Yu F-M, Boonmee S, Eungwanichayapant PD, Wen T-C (2017) Taxonomy of Macromotettixoides with the description of a new species (Tetrigidae, Metrodorinae). ZooKeys 645: 13-25. https://doi.org/10.3897/zookeys.645.9055
Figure 3 - Habitat environment of Macromotettixoides parvula sp. n. a a gully in a broad-leaved forest b border of a stream. Pictures were photographed by Lingsheng Zha in China, Guizhou, Leishan, Leigongshan Mountain, 2 Aug 2016.
Figure 1 from: Zha L-S, Yu F-M, Boonmee S, Eungwanichayapant PD, Wen T-C (2017) Taxonomy of Macromotettixoides with the description of a new species (Tetrigidae, Metrodorinae). ZooKeys 645: 13-25. https://doi.org/10.3897/zookeys.645.9055
Figure 1 - Macromotettixoides parvula sp. n. a oblique-lateral view of female body b lateral view of female body c dorsal view of male body. Scale bars 1.0 mm.
Spatial profile of tumor microenvironment in PD-L1-negative and PD-L1-positive triple negative breast cancer
<p><strong>Supplementary Materials</strong></p>
Novel Strategy to Regulate PD-L1 Expression and Enhance Anti-Tumor Effect
<p>Figs source data</p> <p> </p>
Novel Strategy to Regulate PD-L1 Expression and Enhance Anti-Tumor Effect
<p>Figs source dat</p>
Supplementary material 2 from: Barord GJ, Combosch DJ, Giribet G, Landman N, Lemer S, Veloso J, Ward PD (2023) Three new species of Nautilus Linnaeus, 1758 (Mollusca, Cephalopoda) from the Coral Sea and South Pacific. ZooKeys 1143: 51-69. https://doi.org/10.3897/zookeys.1143.84427
Supplemental video 2
Supplementary material 1 from: Barord GJ, Combosch DJ, Giribet G, Landman N, Lemer S, Veloso J, Ward PD (2023) Three new species of Nautilus Linnaeus, 1758 (Mollusca, Cephalopoda) from the Coral Sea and South Pacific. ZooKeys 1143: 51-69. https://doi.org/10.3897/zookeys.1143.84427
Supplemental video 1
Supplementary material 3 from: Barord GJ, Combosch DJ, Giribet G, Landman N, Lemer S, Veloso J, Ward PD (2023) Three new species of Nautilus Linnaeus, 1758 (Mollusca, Cephalopoda) from the Coral Sea and South Pacific. ZooKeys 1143: 51-69. https://doi.org/10.3897/zookeys.1143.84427
Supplemental video 3
Inhibition of the α4β1 integrin activity by small Tellurium molecules Regulates PD-L1 Expression and Enhances Anti-Tumor Effect
<p>Figs source data</p>
Effect of Rotigotine on Motor Symptoms in Patients With Advanced Parkinson's Disease (PD) With Motor Fluctuations and Symptoms of Gastrointestinal Dysfunction
ClinicalTrials.gov study NCT01536015. IPD Sharing: Not stated. Countries: 1. Publications: 0.
PD-L1 t-haNK, N-803 IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC
ClinicalTrials.gov study NCT06239220. IPD Sharing: YES. Countries: 1. Publications: 0.
Dietary Education Intervention Impact on Dietary Protein Intake in PD
ClinicalTrials.gov study NCT02426580. IPD Sharing: YES. Countries: 0. Publications: 0.
Phase I Study of the Safety, Tolerability, PK & PD of Lomitapide in Japanese and Caucasian Subjects With Elevated LDL-C
ClinicalTrials.gov study NCT01760187. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 (PD-L1) Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
ClinicalTrials.gov study NCT04128696. IPD Sharing: YES. Countries: 26. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.