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812 results for “Target identification”
Identification of Potential Multi-Target Directed Ligands Through Virtual Screening and Molecular Dynamics Simulation Approach for the Treatment of Alzheimer's Disease
<p>Alzheimer’s disease (AD) is a multifactorial neurological disorder characterized by memory loss and cognitive impairment. The currently available single-targeting drugs have miserably failed in the treatment of AD and multi-target directed ligands (MTDLs) are being explored as an alternative strategy. Cholinesterase and monoamine oxidase enzymes are reported to play crucial role in the pathology of AD and multipotent ligands targeting these two enzymes simultaneously, are under various phases of design and development. Recent studies have revealed that computational approaches are robust and trusted tools for the identification of novel therapeutics. The current research work is focused on the development of potential multitarget directed ligands that simultaneously inhibit acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) enzymes employing structure-based virtual screening (SBDD) approach. The ASINEX database was screened after applying pan assay interference and drug likeness filter to identify novel molecules using three docking precision criteria Highthroughput virtual screening (HTVS), Standard Precision (SP), and extra precision (XP). Additionally, binding free energy calculations, ADME and molecular dynamic simulations were also employed to get structural insights into mechanism of protein-ligand binding and pharmacokinetic properties. Three lead molecules viz. AOP19078710, BAS00314308 and BDD26909696 were successfully identified which displayed binding score of -10.565, -10.543 & -8.066 kcal/mol against AChE and -11.019, -12.357 & -10.068 kcal/mol against MAO-B, better score as compared to the standard inhibitors. In near future, these molecules will be synthesized and evaluated through in vitro and in vivo assays for their inhibition potential against AChE and MAO-B enzymes.</p>
Data for the manuscript "Identification and structural studies of the crucial RNAi target of SARS-CoV-2 through molecular dynamics simulations"
<p>Simulation datasets for manuscript titled "<strong>Identification and structural studies of the crucial RNAi target of SARS-CoV-2 through molecular dynamics simulations"</strong></p>
Identification of target genes of miR-31 in PTC cells by RNA sequencing
GEO Series GSE193159. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Identification of putative targets of Nkx2-5 in Xenopus laevis using gene expression analysis and cross-species annotation
GEO Series GSE29791. Xenopus laevis. 12 samples. Type: Expression profiling by array.
Identification of novel DVL3 cancer-associated target genes
GEO Series GSE165775. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Identification of heat stress-responsive rice microRNAs and their target genes by high-throughput sequencing and degradome analysis
GEO Series GSE77510. Oryza sativa Indica Group. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Identification of genes targeted by miR-501 in two gastric cancer cell lines.
GEO Series GSE214227. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide identification of transcriptional targets for H4K12la during uterine stromal cells decidualization in mice
GEO Series GSE242113. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of regulatory targets of the cereal VERNALIZATION1 transcription factor
GEO Series GSE56585. Hordeum vulgare. 6 samples. Type: Expression profiling by array.
Identification of miR-29b targets using 3-cyanovinylcarbazole containing mimics
GEO Series GSE120765. Homo sapiens; Mus musculus. 36 samples. Type: Other.
Identification of AtGBF3-regulated targets in Arabidopsis thaliana under combined stress of drought and Pseudomonas syringae infection
GEO Series GSE132564. Arabidopsis thaliana. 10 samples. Type: Expression profiling by array.
Identification and Targeting of Treatment Resistant Progenitor Populations in T-cell Acute Lymphoblastic Leukemia
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.