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821
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ShareScore release 0.9.0
Dataset results
821 results for “epigenetic regulation”
African swine fever infection epigenetically regulate host membrane protein-encoding genes
GEO Series GSE231435. Sus scrofa. 44 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Lysine Pyruvylation Mediated by HAT1/p300-SIRT3 Couples Glycolytic Flux to Epigenetic Regulation [RNA-seq]
GEO Series GSE315215. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic regulation of tumor-associated myeloid cell activity by CBP/EP300 bromodomain
GEO Series GSE124333. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic regulation of tumor-associated myeloid cell activity by CBP/EP300 bromodomain [ChIP-seq]
GEO Series GSE124331. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic regulation of transcription and virulence in Trypanosoma cruzi by O-linked thymine glucosylation of DNA
GEO Series GSE26754. Trypanosoma cruzi. 8 samples. Type: Expression profiling by high throughput sequencing.
Lysine Pyruvylation Mediated by HAT1/p300-SIRT3 Couples Glycolytic Flux to Epigenetic Regulation [RNA-Seq]
GEO Series GSE295252. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns
<p>This database includes the raw data linked with the paper “Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns” accepted for publication on Molecular Psychiatry. This study is part of the longitudinal and multi-centric “Measuring the outcomes of maternal COVID-19-related prenatal exposure (MOM-COPE)” study. Here, we report on the interactive influence of variations in antenatal exposures to maternal pandemic-related stress (PRS) and PM2.5 on SLC6A4 DNAm levels in newborns.</p> <p>Procedures</p> <p>Mother–infant dyads (N=307) were enrolled at delivery during the COVID-19 pandemic. Infants’ methylation status was assessed in 13 CpG sites within the SLC6A4 gene’s region (chr17:28562750–28562958) in buccal cells at birth and women retrospectively report on PRS. PM2.5 exposure throughout the entire gestation and at each gestational trimester was estimated using a spatiotemporal model based on residential address.</p> <p> </p> <p>Among several potentially confounding socio-demographic and health-related factors, infant’s sex was significantly associated with infants’ SLC6A4 DNAm levels, thus hierarchical regression models were adjusted for infant’s sex.</p> <p>Mother–infant dyads (N = 276) were recruited at delivery. Maternal trait anxiety, as a marker of antenatal chronic stress exposure, was assessed soon after delivery using the Stait-Trait Anxiety Inventory (STAI-Y). Infants’ BDNF DNAm at birth was assessed in 11 CpG sites in buccal cells whereas infants’ NE was assessed at 3 (N = 225) and 6 months (N = 189) using the Infant Behavior Questionnaire-Revised (IBQ-R).</p> <p>Analytical plan</p> <p>Principal component analysis (PCA) was used to reduce the number of CpG sites into a smaller set of factors.</p> <p>A four-factor solution, where the targeted CpG sites were aggregated in 4 main factors, showed the best fit to the data (Table 2). Principal Component 1 (PC1; composed of 6 CpG sites) and Principal Component 2 (PC2; composed of 3 CpG sites) accounted, respectively, for 31.6% and 12.8% of the total variance in SLC6A4 DNAm and were used in further analyses. Pearson correlations and independent samples t-tests were employed to explore the potential effect of sociodemographic and health-related variables on infant methylation levels. All variables found to be significantly associated with the outcomes examined were included as covariates in subsequent analyses. Separate hierarchical regression analyses were performed to evaluate the independent and interactive effects of maternal PRS and exposure to air pollution on infant methylation levels.</p> <p>Findings in brief</p> <p>Higher levels of SLC6A4 DNAm at 6 CpG sites were found in newborns born to mothers reporting higher levels of antenatal PRS and greater PM2.5 exposure across gestation, while adjusting for infant’s sex. These effects were especially evident when exposure to elevated PM2.5 occurred during the second trimester of pregnancy.</p>
PANDA epigenetically regulates the trade-off between panicle number and grain size in rice [RNA-Seq]
GEO Series GSE183794. Oryza sativa. 4 samples. Type: Expression profiling by high throughput sequencing.
Selective identification of epigenetic regulators at methylated genomic sites by SelectID [ChIP-seq]
GEO Series GSE275657. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PfSnf2L - an epigenetic regulator of just-in-time expression and gametocyte formation
GEO Series GSE228949. Plasmodium falciparum. 115 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
TFAP2C affects epigenetic reprogramming of porcine embryo development by regulating global epigenetic modification
GEO Series GSE230288. Sus scrofa. 4 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma
GEO Series GSE79113. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Insight into the epigenetic regulation of gene expression in the bloodstream and procyclic forms of Trypanosoma brucei through the involvement of G-Quadruplexes
GEO Series GSE275674. Trypanosoma brucei. 16 samples. Type: Expression profiling by high throughput sequencing.
CRISPR Phenotypic enrichment screen for epigenetic regulators of MEIS1 expression in acute myeloid leukemia (AML) [CRISPRScreens]
GEO Series GSE217778. Homo sapiens. 6 samples. Type: Other.
Epigenetic regulation of gene expression is instructed by promoter sequence and refined by developmental progression [genomic]
GEO Series GSE41447. Mus musculus. 16 samples. Type: Methylation profiling by genome tiling array; Genome binding/occupancy profiling by genome tiling array.
Estrogen-independent Epigenetic Mechanisms Regulate Gender Dimorphisms in Cardiac Reparative Functions of Bone Marrow Progenitor Cells [Cut & Tag]
GEO Series GSE253057. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential [MeDIP-Seq]
GEO Series GSE159465. Homo sapiens. 24 samples. Type: Methylation profiling by high throughput sequencing.
Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens (ATAC-Seq_2)
GEO Series GSE281868. Homo sapiens; Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic Memory of Cross-Regulation by Papain and CpG in Lung Stromal Cells
GEO Series GSE283765. Mus musculus. 26 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic checkpoint regulates anti-tumor immunity of CD4 T cell in Hepatocellular carcinoma
GEO Series GSE239507. Homo sapiens. 2 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.