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954 results for “survival data”
Data from: Shorter juvenile telomere length is associated with higher survival to spawning in migratory Atlantic salmon
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Data from: Coping with the cold: energy storage strategies for surviving winter in freshwater fish
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Data from: Marker-dependent associations among oxidative stress, growth and survival during early life in a wild mammal
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Data from: Immunosenescence and the ability to survive bacterial infection in the red flour beetle Tribolium castaneum
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Data from: Heterozygosity and survival in blue tits (Cyanistes caeruleus): contrasting effects of presumably functional and neutral loci
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Data from: Conjugation is necessary for a bacterial plasmid to survive under protozoan predation
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Data from: Species wood density and the location of planted seedlings drive early-stage seedling survival during tropical forest restoration
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Data from: Pleistocene survival on central Alpine nunataks: genetic evidence from the jumping bristletail Machilis pallida
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Data from: Senescence in duckweed: age-related declines in survival, reproduction, and offspring quality
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Data from: Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance
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Data from: Maternal density stress and coccidian parasitism: synergistic effects on overwinter survival in root voles
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Data from: Experimentally enhanced performance decreases survival in nature
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Data from: Mountain Plover habitat selection and nest survival in relation to weather variability and spatial attributes of Black-tailed Prairie Dog disturbance
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Data from: Social chromosome variants differentially affect queen determination and the survival of workers in the fire ant Solenopsis invicta
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Data from: Deciphering a survival strategy during the interspecific competition between Bacillus cereus MSM-S1 and Pseudomonas sp. MSM-M1
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Data from: Anti-pathogen protection versus survival costs mediated by an ectosymbiont in an ant host
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Single-cell RNA-sequencing data and functional analysis revealed that ACC1, a rate limiting enzyme of fatty acid biosynthesis, is responsible for survival of thymic iNKT cells.
GEO Series GSE248939. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Data from: Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer
<p>Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial efforts have been directed towards identification and development of pharmaceutical CDK inhibitors. Insights into the biological consequences of CDK inhibition in specific tumor types have led to the successful development of CDK4/6 inhibitors as treatments for certain types of breast cancer. More recently, the development of a new generation of pharmaceutical inhibitors of CDK enzymes that regulate the transcription of key oncogenic and pro-survival proteins, including CDK2 and CDK9, have entered clinical development. Here, we provide the first disclosure of the chemical structure of fadraciclib (CYC065), a CDK inhibitor and clinical candidate designed by further optimization from the aminopurine scaffold of seliciclib. We describe its synthesis and mechanistic characterization. Fadraciclib exhibits improved potency and selectivity for CDK2 and CDK9 compared to seliciclib, and also displays high selectivity across the kinome. We show that the mechanism of action of fadraciclib is consistent with potent inhibition of CDK9-mediated transcription, decreasing levels of RNA polymerase II C-terminal domain serine 2 phosphorylation, the pro-survival protein Myeloid Cell Leukemia 1 (MCL1) and MYC oncoprotein, and inducing rapid apoptosis in cancer cells. This cellular potency and mechanism of action translate to promising anti-cancer activity in human leukemia mouse xenograft models. Studies of leukemia cell line sensitivity identify mixed lineage leukemia (<i>MLL</i>) gene status and the level of B-cell lymphoma 2 (BCL2) family proteins as potential markers for selection of patients with greater sensitivity to CYC605. We show that the combination of fadraciclib with BCL2 inhibitors, including venetoclax, is synergistic in leukemic cell models, as predicted from simultaneous inhibition of MCL1 and BCL2 pro-survival pathways. Fadraciclib preclinical pharmacology data support its therapeutic potential in CDK9- or CDK2-dependent cancers and as a rational combination with BCL2 inhibitors in hematological malignancies. Fadraciclib is currently in Phase 1 clinical studies in patients with advanced solid tumors (<a href="https://clinicaltrials.gov/ct2/show/NCT02552953?cond=CYC065&rank=2">NCT02552953</a>) and also in combination with venetoclax in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) (<a href="https://clinicaltrials.gov/ct2/show/NCT03739554?cond=CYC065&rank=1">NCT03739554</a>) and relapsed refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) (<a href="https://clinicaltrials.gov/ct2/show/NCT04017546?cond=CYC065&draw=1&rank=2">NCT04017546</a>)</p>
Data from: Temperature-dependent development and survival of an invasive genotype of wheat curl mite, Aceria tosichella
<p><strong>Filename: Development.xlsx</strong></p> <p>Variables:</p> <p>1. id_spec - specimen ID<br> 2. temp - temperature of incubation<br> 3. trial - replication ID<br> 4. larv - number of days needed to reach larva stage <br> 5. q_larv - number of days needed to reach quiescent larva stage <br> 6. nymph - number of days needed to reach nymph stage <br> 7. q_nymph - number of days needed to reach quiescent nymph stage <br> 8. adult - number of days needed to reach adult stage <br> 9. egg - number of days needed to oviposit egg of next generation </p> <p><strong>Filename: Survival.xlsx</strong></p> <p>Variables:</p> <p>1. id_spec - specimen ID<br> 2. temp - temperature of incubation<br> 3. time - number of days when individual was observed alive<br> 4. stage - developmental stage which individual reached before death<br> 5. sex - sex of an individual (F - female; M - male; NA - unknown)<br> 6. status - 0 - censored observation; 1 - observed event of death</p>
Data from: When perception reflects reality: non-native grass invasion alters small mammal risk landscapes and survival
1. Modification of habitat structure due to invasive plants can alter the risk landscape for wildlife by, for example, changing the quality or availability of refuge habitat. Whether perceived risk corresponds with actual fitness outcomes, however, remains an important open question. We simultaneously measured how habitat changes due to a common invasive grass (cheatgrass, <i>Bromus tectorum</i>) affected the perceived risk, habitat selection, and apparent survival of a small mammal, enabling us to assess how well perceived risk influenced important behaviors and reflected actual risk. 2. We measured perceived risk by nocturnal rodents using a giving-up density foraging experiment with paired shrub (safe) and open (risky) foraging trays in cheatgrass and native habitats. We also evaluated microhabitat selection across a cheatgrass gradient as an additional assay of perceived risk and behavioral responses for deer mice (<i>Peromyscus maniculatus</i>) at two spatial scales of habitat availability. Finally, we used mark-recapture analysis to quantify deer mouse apparent survival across a cheatgrass gradient while accounting for detection probability and other habitat features. 3. In the foraging experiment, shrubs were more important as protective cover in cheatgrass dominated habitats, suggesting that cheatgrass increased perceived predation risk. Additionally, deer mice avoided cheatgrass and selected shrubs, and marginally avoided native grass, at two spatial scales. 4. Deer mouse apparent survival varied with a cheatgrass-shrub interaction, corresponding with our foraging experiment results, and providing a rare example of a native plant mediating the effects of an invasive plant on wildlife. 5. By synthesizing the results of three individual lines of evidence (foraging behavior, habitat selection, and apparent survival), we provide a rare example of linkage between behavioral responses of animals indicative of perceived predation risk and actual fitness outcomes. Moreover, our results suggest that exotic grass invasions can influence wildlife populations by altering risk landscapes and survival.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.