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829
datasets available to search
ShareScore release 0.9.0
Dataset results
829 results for “CRISPR screening”
Large-scale bidirectional arrayed CRISPR screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation
GEO Series GSE295558. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
CRISPR Phenotypic enrichment screen for epigenetic regulators of MEIS1 expression in acute myeloid leukemia (AML) [CRISPRScreens]
GEO Series GSE217778. Homo sapiens. 6 samples. Type: Other.
Paired CRISPR screens to map gene regulation in cis and trans (CUT&RUN)
GEO Series GSE255699. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Integration of a scalable parallel reporter genes for qRT-PCR based enhancer screening with CRISPR dCas9 activation and supershift EMSA identifies impaired BACH1 repression of ST8SIA1 to contribute to
GEO Series GSE160672. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
CRISPR screen identifies genes that sensitize AML cells to double negative T cell therapy
GEO Series GSE157618. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
In vivo CRISPR screen identifies SNRPC as a regulator for facilitating triple-negative breast cancer progression [ChIP-Seq]
GEO Series GSE227185. Homo sapiens. 54 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens (ATAC-Seq_2)
GEO Series GSE281868. Homo sapiens; Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The CRISPR Screen sequencing raw data
GEO Series GSE217997. Homo sapiens. 10 samples. Type: Other.
Dataset related to article "CRISPR Genome-Wide screening reveals chemosensor receptors as lipid-detecting regulators of macrophage functions in cancer"
<p>This record contains raw data related to article "CRISPR Genome-Wide screening reveals chemosensor receptors as lipid-detecting regulators of macrophage functions in cancer"</p> <p><strong><span>Abstract</span></strong><span>: </span></p> <p><span>The infiltration of macrophages is considered a hallmark of cancer progression and re-education of tumor-associated macrophages towards an anti-tumour status is considered a promising strategy of cancer immunotherapy. However, the mechanisms governing macrophage education by cancer cells remain largely elusive, posing challenges for therapeutic exploitation. To gain deeper insights into TAMs' plasticity, we conducted an unbiased genome-wide CRISPR screening on primary macrophages. Our investigation confirmed the role of known regulators, including Stat6, in orchestrating TAMs' responses and unveiled novel insights into TAMs' behaviour. We identified olfactory and vomeronasal receptors, commonly referred to as chemosensors, as major drivers of macrophages tumor-supportive status in multiple cancers. Collectively, our findings implicate chemosensors in macrophage sensing of the lipid-enriched milieu and highlight these receptors as therapeutic targets for enhancing antitumor immunity.</span></p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.