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837
datasets available to search
ShareScore release 0.9.0
Dataset results
837 results for “associational effects”
Eradiation of leukemia by effective reprogramming-associated cell elimination (ERACE)
GEO Series GSE78739. Mus musculus. 18 samples. Type: Expression profiling by array.
Effect of cathepsin inhibitors in signals associated with Th1 and Th2 mediators by Dendritic Cells
GEO Series GSE66738. Mus musculus. 14 samples. Type: Expression profiling by array.
Anti-IgE Effect of Naturally Occurring Arctigenin on Food Allergy Association with a Distinct Transcriptome Profile
GEO Series GSE183215. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of DLBCL-associated NOTCH2 mutants on genomic RBP-J localization and H3K27 acetylation
GEO Series GSE231623. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Study of microRNA associated with metformin’s anti-tumor effect [Huh7 cells]
GEO Series GSE44204. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by array.
Effect of Tormentic Acid on metabolic-associated fatty liver disease in mice
GEO Series GSE222807. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Study of microRNA associated with metformin’s anti-tumor effect [pancreatic cancer]
GEO Series GSE37406. Homo sapiens. 24 samples. Type: Non-coding RNA profiling by array.
Anti-proliferative effect of Cinobufagin on acute myeloid leukemia cells with repression of c-Myc pathway associated genes
GEO Series GSE190997. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Microbiota dysbiosis associated with type 2 diabetes-like effects caused by chronic exposure to a mixture of chlorinated persistent organic pollutants in zebrafish [II]
GEO Series GSE233632. Danio rerio. 29 samples. Type: Other.
Anti-proliferative effect of Cinobufagin on acute myeloid leukemia cells with repression of c-Myc pathway associated genes (ChIP-Seq)
GEO Series GSE190995. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity "
<p>This record contains raw data related to article “Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity"</p> <p><strong>Background: </strong> Tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer and hinder the antitumoral efficacy of most treatments currently applied in the clinic. Previous studies have evaluated the antitumoral immune response triggered by (TLR) agonists, such as poly(I:C), imiquimod (R837) or resiquimod (R848) as monotherapies; however, their combination for the treatment of cancer has not been explored. This study investigates the antitumoral efficacy and the macrophage reprogramming triggered by poly(I:C) combined with R848 or with R837, versus single treatments.</p> <p><strong>Methods: </strong> TLR agonist treatments were evaluated in vitro for toxicity and immunostimulatory activity by Alamar Blue, ELISA and flow cytometry using primary human and murine M-CSF-differentiated macrophages. Cytotoxic activity of TLR-treated macrophages toward cancer cells was evaluated with an in vitro functional assay by flow cytometry. For in vivo experiments, the CMT167 lung cancer model and the MN/MCA1 fibrosarcoma model metastasizing to lungs were used; tumor-infiltrating leukocytes were evaluated by flow cytometry, RT-qPCR, multispectral immunophenotyping, quantitative proteomic experiments, and protein-protein interaction analysis.</p> <p><strong>Results: </strong> Results demonstrated the higher efficacy of poly(I:C) combined with R848 versus single treatments or combined with R837 to polarize macrophages toward M1-like antitumor effectors in vitro. In vivo, the intratumoral synergistic combination of poly(I:C)+R848 significantly prevented tumor growth and metastasis in lung cancer and fibrosarcoma immunocompetent murine models. Regressing tumors showed increased infiltration of macrophages with a higher M1:M2 ratio, recruitment of CD4<sup>+</sup> and CD8<sup>+</sup> T cells, accompanied by a reduction of immunosuppressive CD206<sup>+</sup> TAMs and FOXP3<sup>+</sup>/CD4<sup>+</sup> T cells. The depletion of both CD4<sup>+</sup> and CD8<sup>+</sup> T cells resulted in complete loss of treatment efficacy. Treated mice acquired systemic antitumoral response and resistance to tumor rechallenge mediated by boosted macrophage cytotoxic activity and T-cell proliferation. Proteomic experiments validate the superior activation of innate immunity by poly(I:C)+R848 combination versus single treatments or poly(I:C)+R837, and protein-protein-interaction network analysis reveal the key activation of the STAT1 pathway.</p> <p><strong>Discussion: </strong> These findings demonstrate the antitumor immune responses mediated by macrophage activation on local administration of poly(I:C)+R848 combination and support the intratumoral application of this therapy to patients with solid tumors in the clinic.</p>
A model framework on air-snow vapor exchange and the associated isotope effects at Dome Argus, Antarctica
<p>Simulation result and Matlab code</p>
Dataset related to Article "A SINGLE-GROUP STUDY ON THE EFFECT OF ONABOTULINUMTOXINA IN PATIENTS WITH CHRONIC MIGRAINE ASSOCIATED TO MEDICATION OVERUSE HEADACHE: PAIN CATASTROPHIZING PLAYS A ROLE"_ submitted
<p>THIS DATASET INCLUDES INFORMATION ON HEADACHE FREQUENCY, MEDICATION INTAKE, MIDAS SCORE, AVERAGE PAIN, HIT-6, ASC-12 AND PCS REFERRED TO PATIENTS RECEIVING ONABOTULINUMTOXINA AS PROPHYLAXIS FOR CM-MOH OVER 12 MONTHS.</p>
Dataset of Publication entitled "Prevention of non-ventilator-associated hospital-acquired pneumonia: results of a hybrid effectiveness-implementation trial"
<p>This dataset includes the aggregated data analyzed in the manuscript entitled "Intervention to prevent non-ventilator-associated hospital-acquired pneumonia: results of a hybrid effectiveness-implementation trial" by Wolfensberger A. et al.</p>
The linker histone H1.2 directs the genome-wide chromatin-association and facilitates the biological effects of the retinoblastoma tumour suppressor protein
GEO Series GSE98728. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Effect of heat treatment and osmotic storage on control of fungi associated with Inga vera seeds
<p>Figure 1. Weight gain (WG) of <em>I. vera</em> seeds soaked in distilled water or osmoconditioned in -1.0, -2.0, -3.0, -4.0 and -5, 0 MPa PEG 6000 solutions at 7°C, for 216 hours.</p> <p>Figure 2. Representative scheme of heat treatment of<em> I. vera</em> seeds. HT = heat treatment (55 °C for 30 min); HT0 = HT applied at the beginning of the experiment; HT1 = HT applied initially and reapplied at 25 days of storage; HT2 = HT applied initially and reapplied at 25 and 50 days of storage. 1st HT = HT applied at the 1st day (seeds not stored); 2nd HT = HT applied after 25 days of storage; 3rd HT = HT applied after 50 days of storage.</p> <p>Figure 3. Representative scheme of the storage of <em>I. vera</em> seeds. Initial batch = recently processed seeds; CONT = control; HT = Heat treatment (55 °C for 30 min); HT0 = HT applied at the beginning of the experiment; HT1 = HT applied initially and reapplied at 25 days of storage; HT2 = HT applied initially and reapplied at 25 and 50 days of storage; PB = storage in polyethylene bag; PEG = storage in polyethylene glycol solution; * = assessments of germination, water content, dry mass content, water potential, respiratory rates, seed health test and electrical conductivity carried out on the 1st, 25th, 50th and 75th day.</p> <p>Figure 4. Frequency (%) of each fungus genus in relation to all fungal genera found in <em>I. vera</em> seeds.</p> <p>Figure 5. Frequency (%) of fungi found in <em>I. vera</em> seeds stored in PB or PEG, for 25, 50 and 75 days.</p> <p>Figure 6. Frequency (%) of fungi found in <em>I. vera</em> seeds by storage period.</p> <p>Figure 7. Incidence of <em>Fusarium </em>sp., <em>Ceratocystis </em>sp., <em>Cladosporium</em> sp. and <em>Penicillium</em> sp. in <em>I. vera</em> seeds subjected to heat treatments (HT0, HT0 PB, HT0 PEG, HT1 PB, HT1 PEG, HT2 PB, HT2, PEG) or not (CONT, CONT PB, CONT PEG), before (A) and after storage for 25 (B), 50 (C) and 75 (D) days.</p> <p>Figure 8 – Severity of <em>Fusarium</em> sp. in <em>I. vera</em> seeds submitted to heat treatments (HT0, HT0 PB, HT0 PEG, HT1 PB, HT1 PEG, HT2 PB, HT2, PEG) or not (CONT, CONT PB, CONT PEG), before (A) and after storage for 25 (B), 50 (C) and 75 (D) days. Zero - seed not infected by the analyzed fungus; Traces - growth up to 10% of the seed, with small colonies, and in a very small number; Low - growth up to 40% of the seed; Moderate - growth from 41 to 100% of the seed, with colonies with superficial and slow growth; High - growth from 41 to 100% of the seed, with a dense and evenly distributed colony.</p> <p>Figure 9 – Severity of <em>Penicillium</em> sp. in <em>I. vera</em> seeds submitted to heat treatments (HT0, HT0 PB, HT0 PEG, HT1 PB, HT1 PEG, HT2 PB, HT2, PEG) or not (CONT, CONT PB, CONT PEG), before (A) and after storage for 25 (B), 50 (C) and 75 (D) days. Zero - seed not infected by the analyzed fungus; Traces - growth up to 10% of the seed, with small colonies, and in a very small number; Low - growth up to 40% of the seed; Moderate - growth from 41 to 100% of the seed, with colonies with superficial and slow growth; High - growth from 41 to 100% of the seed, with a dense and evenly distributed colony.</p> <p>Figure 10 – Severity of <em>Ceratocystis </em>sp. in <em>I. vera</em> seeds submitted to heat treatments (HT0, HT0 PB, HT0 PEG, HT1 PB, HT1 PEG, HT2 PB, HT2, PEG) or not (CONT, CONT PB, CONT PEG), before (A) and after storage for 25 (B), 50 (C) and 75 (D) days. Zero - seed not infected by the analyzed fungus; Traces - growth up to 10% of the seed, with small colonies, and in a very small number; Low - growth up to 40% of the seed; Moderate - growth from 41 to 100% of the seed, with colonies with superficial and slow growth; High - growth from 41 to 100% of the seed, with a dense and evenly distributed colony.</p> <p>Figure 11 – Severity of <em>Cladosporium</em> sp. in <em>I. vera</em> seeds submitted to heat treatments (HT0, HT0 PB, HT0 PEG, HT1 PB, HT1 PEG, HT2 PB, HT2, PEG) or not (CONT, CONT PB, CONT PEG), before (A) and after storage for 25 (B), 50 (C) and 75 (D) days. Zero - seed not infected by the analyzed fungus; Traces - growth up to 10% of the seed, with small colonies, and in a very small number; Low - growth up to 40% of the seed; Moderate - growth from 41 to 100% of the seed, with colonies with superficial and slow growth; High - growth from 41 to 100% of the seed, with a dense and evenly distributed colony.</p> <p>Figure 12. Germination – Germ. (%) and germination after repiration – Germ. Resp. (%) (A, B, C, D), electrical conductivity – EC (µS.cm-1.g-1) (E, F, G, H) and water potential – Pw (MPa) (I, J, K, L) of <em>I. vera</em> seeds subjected to heat treatments (HT0, HT0 PB, HT0 PEG, HT1 PB, HT1 PEG, HT2 PB, HT2, PEG) or not (CONT, CONT PB, CONT PEG), before (A) and after storage for 25 (B), 50 (C) and 75 (D) days, before (A, E, I) and after 25 (B, F, J), 50 (C, G, K) and 75 (D, H, L) days of storage. Means followed by the same letter do not differ by Tukey's test, at 5% probability.</p> <p>Figure 13. Oxygen consumption (µmol.gMS-1.d-1) (A, B, C, D), carbon dioxide production (µmol.gMS-1.d-1) (E, F, G, H) and respiratory quotient (CO2.O2-1) (I, J, K, L) of <em>I. vera</em> seeds submitted to heat treatments (HT0, HT0 PB, HT0 PEG, HT1 PB, HT1 PEG, HT2 PB, HT2, PEG) or not (CONT, CONT PB, CONT PEG), before (A, E, I) and after 25 (B, F, J), 50 (C, G, K) and 75 (D, H, L) days of storage. Means followed by the same letter (lower case, compares the same treatment at 12, 21 and 35 days; upper case, compares treatments at each time point: 12, 21 and 35 days) do not differ from each other by Tukey's test at 5% probability.</p> <p>Figure 14. Darkness of <em>I. vera</em> seeds stored for 75 days in PB (CONT PB, HT0 PB, HT2 PB) and PEG (CONT PEG, HT0 PEG, HT2 PEG).</p>
Effects of First-Year COVID-19 Pandemic on Urology Practice in Three Major Arab Countries: Sub-Analysis of a Survey by Arab Association of Urology Research Group
<p>Effects of First-Year COVID-19 Pandemic on Urology Practice in Three Major Arab Countries:Sub-Analysis of a Survey by Arab Association of Urology Research Group</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.