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opennotspecifiedFeb 2020View details →

Fig. 9 in Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα

Fig. 9. Molecular docking of compounds 1–3 toward RXRα-LBD. (A) Docking of 1 to RXRα-LBD. (B) Docking of 2 to RXRα-LBD. (C) Docking of 3 to RXRα-LBD. (D) Binding site of 1 to the RXRα-LBD. (E) Binding site of 2 to the RXRα-LBD. (F) Binding site of 3 to the RXRα-LBD.

opennotspecifiedFeb 2020View details →

Fig. 6 in Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα

Fig. 6. The RXRα transactivation effects of compounds. 293T cells were treated with different concentrations of new compounds (0, 12.5, 25 μΜ), the transactivation activities of reporter gene for RXRα were measured by dual-luciferase reporter gene assay. The values are the mean ± SD for four independent replicates (*p <0.05, **p <0.01, compared with cells treated with 9-cis-RA alone).

opennotspecifiedFeb 2020View details →

Fig. 8 in Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα

Fig. 8. PARP cleavage induction by compound 3. HeLa cells and MCF-7 cells were treated with different concentrations of compound 3 (0, 10, 20, 30 μΜ) for 48 h. The level of cleaved PARP was analyzed by Western blot.

Single-Cell Transcriptomics Reveals Pre-existing COVID-19 Vulnerability Factors in Lung Cancer Patients

This dataset contains the processed scRNA-seq data and code used to investigate the association between lung cancers and COVID-19. Please refer to the article 'Single-Cell Transcriptomics Reveals Pre-existing COVID-19 Vulnerability Factors in Lung Cancer Patients' for the detailed data and method description. covid_cancer.rds: the processed scRNA-seq data saved as a Seurat object. notebooks.zip: Jupyter notebooks containing code for data analysis.

opennotspecifiedSep 2022View details →

Fig. 2. 1H–1H in Antitumoral activity of 1,2,4-oxadiazoles compounds isolated from the Neowerdermannia vorwerkii in liver and colon human cancer cells

Fig. 2. 1H–1H COSY and HMBC key correlations of 3-(pyridin-3-yl)-5-(tiophen-3-yl)-1,2,4-oxadiazole (1), 5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (2) and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (3).

opennotspecifiedSep 2022View details →

Fig. 1. 3 in Antitumoral activity of 1,2,4-oxadiazoles compounds isolated from the Neowerdermannia vorwerkii in liver and colon human cancer cells

Fig. 1. 3-(pyridin-3-yl)-5-(tiophen-3-yl)-1,2,4-oxadiazole (1), 5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (2) and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)- 1,2,4-oxadiazole (3).

Dataset of scientific article: "Effect of miR-34a on expression of clock and clock-controlled genes in human cancer DLD1 and Lovo cells with different backgrounds in respect to p53 functionality and 17β-estradiol-mediated regulation"

The dataset includes "raw" data used for the calculation of gene expression, wound healing test, fluorescence intensity, and MTS test.

opennotspecifiedJun 2021View details →

Fig. 4 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line

Fig. 4. Interaction of compounds 1 (A), 2 (B) and 3 (C) with DNA sequence Seq-1. All three compounds are predicted to intercalate with the DNA base pairs.

opennotspecifiedJun 2021View details →

Fig. 3 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line

Fig. 3. Morphological changes observed in HeLa (top row) and MIA PaCa-2 (bottom row) cells after incubation with gemcitabine (A and E), compound 1 (B and F), compound 2 (C and G) and compound 3 (D and H) at their respective IC50s for 8 h.

MCT1 gene silencing enhances the immune effect of dendritic cells on cervical cancer cells

Statistics for Figure 1-6. Figure S1 Cube maps for the levels of expression for DC markers after sLA exposure and LPS challenge. DCs were first infected with Ad-shCtrl and Ad-shMCT1 adenoviruses for 24 h, then co-cultured with 50 mM sLA or PBS for 48 h, and finally stimulated with 1 ug/mL LPS for 24 h. Flow cytometry was used to detect the expression of CD1a (A), CD80 (B), CD83 (C), CD86 (D) and MHCII (E) in DCs. The column height represents the average value, and the bar of the column is the standard deviation. P value was calculated by Tukey’s honestly significant difference (HSD) test following analysis of variance (ANOVA) testing between multiple groups or by Student's t test between (PBS vs sLA treatment Table S1. Statistics for Figure S1.

MCT1 gene silencing enhances the immune effect of dendritic cells on cervical cancer cells

Figur 1. xlsx, Results of ANOVA as presented in Figure 1. Figur 2. xlsx, Results of ANOVA as presented in Figure 2. Figur 3. xlsx, Results of ANOVA as presented in Figure 3. Figur 4. xlsx, Results of ANOVA as presented in Figure 4. Figur 5. xlsx, Results of ANOVA as presented in Figure 5. Figur 6. xlsx, Results of ANOVA as presented in Figure 6. Figur s1. xlsx, Results of ANOVA as presented in Figure s1. supplementary figure. docx, Figure S1 Cube maps for the levels of expression for DC markers after sLA exposure and LPS challenge. DCs were first infected with Ad-shCtrl and Ad-shMCT1 adenoviruses for 24 h, then co-cultured with 50 mM sLA or PBS for 48 h, and finally stimulated with 1 ug/mL LPS for 24 h. Flow cytometry was used to detect the expression of CD1a (A), CD80 (B), CD83 (C), CD86 (D) and MHCII (E) in DCs. Table S1. docx, Statistics for Figure S1.

opennotspecifiedMar 2021View details →

Fig. 5 in Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines

Fig. 5. The apoptosis rate of compound 1 in HGC-27 cells. (A) The pro-apoptotic effect of compound 1 in HGC-27 cells was analyzed by flow cytometry. (B) Apoptosis rates of the control group and drug groups. Compound 1 treatment at 3.13, 6.25, 12.5, and 25 μM resulted in a significant increase in apoptosis rates in HGC-27 cells. Data are shown as mean ± SD of three independent experiments. *P <0.05 vs. untreated control.

opennotspecifiedMar 2021View details →

Fig. 4 in Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines

Fig. 4. The pro-apoptotic effect of compound 1 on HGC-27 cells. The cells were treated with different concentrations of 1 for 48 h and visualized for apoptotic bodies under fluorescent microscopy after staining with Hoechst 33,258.

opennotspecifiedMar 2021View details →

Fig. 2 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Fig. 2. Connectivities (bold lines) deduced by the COSY spectrum and significant HMBC correlations (solid arrows) observed for 1–9.

Fig. 10 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 10. Binding pose of 15 with human Pgp. The P-gp model was generated based on the PDB structure of human P-gp (Code: 6QEX) and was portrayed as a cartoon (light green). Residues involved in the interaction were colored yellow, while the surfaces of the hydrophobic pocket packing with 15 were colored light brown red. The hydrogen bonds and hydrophobic forces were shown as red dashed lines and yellow dashed lines, respectively. The structural figures were drawn in Accelrys Discovery Studio 2016. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 9 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 9. (A) Inhibitory effects of 15 on the accumulation of rhodamin-123 (Rho-123) in HepG2/DOX. (B) Inhibitory effects of 15 on the efflux of Rho-123 in HepG2/ DOX. Scale bar = 200 μm.

Fig. 7 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 7. Mediated multidrug resistance (MDR)-reversing effects of the compounds on doxorubicin (DOX)-resistant human hepatocellular carcinoma cell line (HepG2/ DOX).

Fig. 6 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 6. Experimental ECD spectrum of 3 (red line) and calculated ECD spectra (200–400 nm) of (3S,4S,5R,8S,10S,11R,13R,14R,15R)-3a (black line) and (3R,4R,5S,8R,10R,11S,13S,14S,15S)-3b (blue line). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 5 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 5. Experimental CD spectrum (red line) of compound 2, and the Rh2(OCOCF3)4 induced CD spectrum (black line) of 2 in CH2Cl2 for 190–450 nm (left), and the applied bulkiness rule for secondary alcohols (right). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)