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10,812 results for “novels”
Original data for publications: Synthesis, Characterization, and Crystal Structures of Two New Manganese Aceto EMIM Ionic Compounds with Chains of Mn2+ Ions Coordinated Exclusively by Acetate, and: Fe4(OAc)10[EMIM]2: Novel Iron-Based Acetate EMIM Ionic Compound
<p>Origianl data for publications (Part of University of Geneva only):</p> <p>Synthesis, Characterization, and Crystal Structures of Two New Manganese Aceto EMIM Ionic Compounds with Chains of Mn2+ Ions Coordinated Exclusively by Acetate<br> Przemyslaw Dera, Edward Bruffey III, Gregory J. Finkelstein, Colleen Kelly, Angelina Gigante, Hans Hagemann, and Godwin Severa<br> ACS Omega 2020, 5, 25, 15592-15600</p> <p>Fe4(OAc)10[EMIM]2: Novel Iron-Based Acetate EMIM Ionic Compound<br> Godwin Severa, Edward Bruffey, Phuong Q. H. Nguyen, Angelina Gigante, Noemi Leick, Colleen Kelly, Gregory J. Finkelstein, Hans Hagemann, Thomas Gennett, Richard E. Rocheleau, and Przemyslaw Dera,<br> ACS Omega 2021, 6, 31907-31918.</p> <p> </p> <p> </p>
Substrates and a novel component in hSnd2-dependent ER protein targeting
<p>Protein import into the endoplasmic reticulum (ER) is essential for about 30% of the human proteome. It involves targeting of precursor proteins to the ER and insertion into or translocation across the ER membrane. Furthermore, it relies on signals in the precursor polypeptides and components, which read the signals and facilitate their targeting to a protein-conducting channel in the ER membrane, the Sec61 complex. Compared to the SRP- and TRC-dependent pathways, little is known about the SRP-independent/SND pathway. Our aim was to identify additional components and characterize the client spectrum of the human SND pathway. The established strategy of combining depletion of the central hSnd2-component from HeLa cells with proteomic- and differential protein abundance-analysis was used. The SRP and TRC targeting pathways were analyzed in comparison. TMEM109 was characterized as hSnd3. Unlike SRP but similar to TRC, the SND clients are predominantly membrane proteins with N-terminal, central, or C-terminal targeting signals.</p>
Data for: Sensory biases in response to novel complex acoustic signals in male and female gray treefrogs, Hyla chrysoscelis
<p>The sensory bias hypothesis proposes that female preferences for male sexual signaling traits evolved in contexts other than mating. Individuals of both sexes may experience similar selection pressures in these contexts, thus males may have similar biases to females for variation in signal traits. We tested this prediction in the gray treefrog, <em>Hyla chrysoscelis</em>, in which males produce simple advertisement calls, but females are more attracted to certain novel complex stimuli. We recorded males' responses to playbacks of both simple advertisement calls and complex calls consisting of the advertisement call with an acoustic appendage (filtered noise, or heterospecific call pulses) either leading or following the call. We tested females' preferences for the same stimuli in phonotaxis tests. We found evidence for a sensory bias in both sexes: males gave more aggressive calls in response to complex stimuli and females sometimes preferred complex over simple calls. These biases were not universal and depended on both temporal order and appendage characteristics, but how these effects manifested differed between the sexes. Ultimately, our approach of studying biases of both sexes in response to novel mating signals will shed light on the origin of mating preferences, and the mechanisms by which sensory biases operate.</p>
A novel neo-sex chromosome in Sylvietta brachyura (Macrosphenidae) adds to the extraordinary avian sex chromosome diversity among Sylvioidea songbirds
<p><span>We report the discovery of a novel neo-sex chromosome in an African warbler, <em>Sylvietta brachyura</em> (northern crombec; Macrosphenidae). This species is part of the Sylvioidea superfamily, where four separate autosome–sex chromosome translocation events have previously been discovered via comparative genomics of 11 of the 22 families in this clade. Our discovery here resulted from analyses of genomic data of single-species representatives from three additional Sylvioidea families (Macrosphenidae, Pycnonotidae, and Leiothrichidae). In all three species, we confirmed the translocation of a part of chromosome 4A to the sex chromosomes, which originated basally in Sylvioidea. In <em>S. brachyura</em>, we found that a part of chromosome 8 has been translocated to the sex chromosomes, forming a unique neo-sex chromosome in this lineage. Furthermore, the non-recombining part of 4A in <em>S. brachyura</em> is smaller than in other Sylvioidea species which suggests that recombination continued along this region after the fusion event in the Sylvioidea ancestor. These findings reveal additional sex chromosome diversity among the Sylvioidea, where five separate translocation events are now confirmed.</span></p>
Nutritional stress exacerbates impact of a novel insecticide on solitary bees' behaviour, reproduction and survival
<p>Pesticide exposure<span> and food stress are major threats to bees, but their potential synergistic impacts under field-realistic conditions remain poorly understood and are not considered in current pesticide risk assessments. We conducted a semi-field experiment to examine the single and interactive effects of the novel insecticide flupyradifurone (FPF) and nutritional stress on fitness proxies in the solitary bee <em>Osmia bicornis</em>. Individually marked bees were released into flight cages with monocultures of either buckwheat, wild mustard or purple tansy, which were assigned to an insecticide treatment (FPF or control) in a crossed design. Nutritional stress, which was high in bees foraging on buckwheat, intermediate on wild mustard and low on purple tansy, modulated the impact of insecticide exposure. Within the first day after application of FPF, mortality of bees feeding on buckwheat was 29 times higher compared to control treatments, while mortality of FPF exposed and control bees was similar in the other two plant species. Moreover, we found negative synergistic impacts of FPF and nutritional stress on offspring production, flight activity, flight duration, and flower visitation frequency. These results reveal that environmental policies and risk assessment schemes that ignore interactions among anthropogenic stressors will fail to adequately protect bees and the pollination services they provide.</span></p>
Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening model
<p>In vitro models have supported important advances in biomedical sciences and have significantly contributed to reduce the use of experimental animals in different disciplines. We have developed an in vitro model for the evaluation of potential anticoccidial properties of novel compounds aimed to control chicken coccidiosis, a costly disease for the poultry industry. This disease is caused by protozoan parasites of the genus <em>Eimeria</em> (Apicomplexa), and it is mainly controlled by chemoprophylaxis with ionophors and chemical anticoccidials; however, there is an overall agreement about the limitation of these classical drugs and the need to improve current methods of control. Anticoccidial activities of novel compounds is currently evaluated by expensive experiments that involve large numbers of chickens. The use of our in vitro model for the pre-screening of essential oils led to a reduction of 67% of the chickens used in the vivo trials for validation. In this study, we describe how further optimisation of this in vitro model by miniaturisation can have an additional impact on the number of chickens used for the generation of parasite stocks for provision of the in vitro model (which cannot be done in vitro). We have estimated that the use of one chicken could support the evaluation of ten compounds with a 96-well plate format vs. only two with a 24-well plate format, which means an 80% of chicken use reduction. In this study, we have proved that the miniaturisation into a 96-well plate format has perfectly mimicked the invasion and replication observed before in the 24-well plate format. In addition, this format has allowed the simultaneous pre-screening of higher numbers of anticoccidial drugs at different concentrations following streamlined protocols in a more cost-effective way, factors that are beneficial for a wider uptake of the model by other researchers investigating anticoccidial compounds. </p>
Use of A Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism
<p>GIRK channel structure models (PDB structure files) used for Molecular Dynamics simulations.</p>
Identifying a novel ferroptosis-related prognostic score for predicting prognosis in chronic lymphocytic leukemia
<p><span><strong>Background</strong>:</span><span> Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Although the treatment landscape for CLL is rapidly evolving, there are still some patients who remain drug resistance or disease refractory. Ferroptosis is a type of lipid peroxidation-induced cell death and has been suggested with a prognostic value in several cancers. Our research aims to build a prognostic model to improve risk stratification in CLL patients and facilitate more accurate assessment for clinical management.</span></p> <p><span><strong>Methods</strong>: </span><span>The differentially expressed ferroptosis-related genes (</span><span>FRGs) in CLL were filtered through univariate Cox regression analysis based on public databases. Least Absolute Shrinkage and Selection Operator (LASSO) Cox algorithms were performed to construct a prognostic risk model. CIBERSORT and single-sample gene set enrichment analysis (ssGSEA) were performed to estimate the immune infiltration score and immune-related pathways. A total of thirty-six CLL patients in our center were enrolled in this study as a validation cohort. Moreover, a nomogram model was established to predict the prognosis.</span></p> <p><span><strong>Results</strong>: </span><span>A total of differentially expressed 15 FRGs with prognostic significance were screened out. After minimizing the potential risk of overfitting, we constructed a novel ferroptosis-related prognostic score (FPS) model with nine FRGs (AKR1C3, BECN1, CAV1, CDKN2A, CXCL2, JDP2, SIRT1, SLC1A5 and SP1), and stratified patients into low-risk and high-risk groups. Kaplan–Meier analysis showed that patients with high FPS had worse overall survival (OS) (P<0.0001) and treatment-free survival (TFS) (P<0.0001). ROC curves evaluated the prognostic prediction ability of the FPS model. Additionally, the immune cell types and immune-related pathways were correlated with the risk scores in CLL patients. In the validation cohort, the results confirmed </span><span>that the </span><span>high</span><span>-</span><span>risk group was related to worse OS (P<0.0001), progress-free survival (PFS) (P=0.0140) and TFS (P=0.0072). </span><span>In</span><span> the multivariate analysis, only FPS (P=0.011) and CLL-IPI (P=0.010) were independent risk indicators for OS. Furthermore, we established a nomogram including FPS and CLL-IPI which could strongly and reliably predict individual prognosis.</span></p> <p><span><strong>Conclusion</strong>: </span><span>A novel FPS model could be used in CLL for prognostic prediction. The model index may also facilitate the development of new clinical ferroptosis-targeted therapies in patients with CLL.</span></p>
BIOMETSCO progress presentation 2022: Identification of Novel Biomarkers and Drug Targets for the Detection and Elimination of Occult Metastases in Colon Cancer
<p>This is a recorded talk with head of the BIOMETSCO project - Lasse Sommer Kristensen - where he presents the latest project progress.</p> <p>The talk was given at one of ODIN's (the Open Discovery Innovation Network) Knowledge Sharing Events in May 2022.</p> <p> </p> <p> </p>
A novel SNP assay reveals increased genetic variability and abundance following translocations to a remnant Allegheny woodrat population
<p><strong>Background</strong>: Allegheny woodrats (<em>Neotoma magister</em>) are found in metapopulations distributed throughout the Interior Highlands and Appalachia. Historically these metapopulations persisted as relatively fluid networks, enabling gene flow between subpopulations and recolonization of formerly extirpated regions. However, over the past 45 years, Allegheny woodrat populations have experienced population declines throughout their range due to a combination of habitat destruction, declining hard mast availability, and roundworm parasitism. In an effort to initiate genetic rescue of a small, genetically depauperate subpopulation in New Jersey, woodrats were translocated from a genetically robust population in Pennsylvania (PA) in 2015, 2016, and 2017. Herein, we assess the efficacy of these translocations to restore genetic diversity within the recipient population. </p> <p><strong>Results</strong>: We designed a novel 134 single nucleotide polymorphism panel, which was used to genotype the six woodrats translocated from PA and 82 individuals from the NJ population captured before and after the translocation events. These data indicated that a minimum of two translocated individuals successfully produced at least 16 offspring, who reproduced as well. Further, population-wide observed heterozygosity rose substantially following the first set of translocations, reached levels comparable to that of populations in Indiana and Ohio, and remained elevated throughout the following years. Abundance also increased during the monitoring period, suggesting Pennsylvania translocations initiated the genetic rescue of the New Jersey population.</p> <p><strong>Conclusions</strong>: Our results indicate, encouragingly, that very small numbers of translocated individuals can successfully restore the genetic diversity of a threatened population. Our work also highlights the risks of managing very small populations, such as when translocated individuals have greater reproductive success relative to residents. Finally, we note that ongoing work with Allegheny woodrats may broadly shape our understanding of genetic rescue within metapopulations and across heterogeneous landscapes.</p>
Raw data for: Novel food resources and conservation of ecological interactions between the Andean Araucaria and the Austral parakeet
<p><span>In fragile ecosystems, the introduction of exotic species could alter some ecological processes. The Austral parakeet (<em>Enicognathus</em> <em>ferrugineous</em>) shows close ecological and evolutionary relationships with the Andean Araucaria (<em>Araucaria</em> <em>araucana</em>), so any alteration in these interactions may have negative consequences for both partners and for ecosystem functioning and structure. We conducted extensive roadside surveys to estimate the abundance of parakeets in the northern Patagonian Andes over four years and recorded the food plants consumed by foraging flocks. The use of native habitats and humanized areas like villages and farms was influenced by Araucaria seed crop. In masting years, the large seed crop allowed a massive use of this resource during the non-breeding season, and even during the breeding season. The exploitation of exotic plants was minor in the masting year, but became predominant in non-masting years, especially during the non-breeding season. This feeding switch towards exotic plants primarily arose because the low Araucaria seed crop in non-masting years is entirely consumed just after production by domestic and wild exotic mammals living in Araucaria forests year-round, thus forcing the displacement of parakeets towards anthropic habitats to exploit exotic plants. Given the degradation of the remaining Andean Araucaria forests due to the impact of exotic mammals on the ecological interaction between Araucaria and Austral parakeets, ambitious programs to exclude or reduce the density of these alien mammals, including livestock, are warranted. </span></p>
Can native predators be used as a stepping stone to reduce prey naivety to novel predators?
<p>Predator naivety negatively affects reintroduction success and this threat is exacerbated when prey encounters predators with which they have had no evolutionary experience. While methods have been developed to inculcate fear into such predator-naïve individuals, none have been uniformly successful. Exposing ontogenetically- and evolutionary-naïve individuals firstly to native predators may be an effective stepping stone to improved responses to evolutionarily novel predators. We focused on greater bilbies (Macrotis lagotis) and capitalised on a multi-year mammalian recovery experiment whereby western quolls (Dasyurus geoffroii) were reintroduced into parts of a large fenced reserve that contained a population of naïve bilbies. We quantified a suite of antipredator behaviours and measures of general wariness across quoll-exposed and quoll-naive bilby populations. We then translocated both quoll-exposed and quoll-naïve individuals into a large enclosure that contained feral cats (Felis catus) and monitored several behaviours. We found that bilbies can respond appropriately to quolls but found only limited support that experience with quolls better prepared bilbies to respond to cats. Both populations of bilbies rapidly modified their behaviour in a similar manner following their reintroduction to a novel environment. These results may have emerged due to insufficient prior exposure to quolls, inappropriate behavioural tests or insufficient predation risk during cat exposure. Alternatively, quolls and cats are only distantly related and may not share sufficient similarities in their predatory cues or behaviour to support such a learning transfer. Testing this stepping stone hypothesis with more closely-related predator species and under higher predation risk would be informative.</p>
Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody
<p>Raw data associated to the study entitled "Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody", including:</p> <p>- Synthesis development: experimental procedures and characterization</p> <p>- DLS data for CxxTreSuc excipients</p> <p>- Cytotoxicity</p>
A novel technique to simulate and characterize a yarn's mechanical behavior based on a geometrical fiber model extracted from micro-CT imaging: geometry and simulation data
<p>This dataset contains the original µCT scan data, the scripts and intermediate results for the generation of the geometrical fiber model, as well as the structural simulation files and their experimental validation data described in the paper <a href="https://journals.sagepub.com/doi/10.1177/00405175221137009">"A novel technique to simulate and characterize a yarn's mechanical behavior based on a geometrical fiber model extracted from micro-CT imaging"</a>, published in Textile Research Journal.</p>
The Romanian Novel of the Nineteenth Century Database
<p>The data used in the following dataset was collected from <em>The Chronological Dictionary of the Romanian Novel from Its Origins to the Year 2000</em>, edited by the Romanian Academy. The dataset accounts for all the editorial production related to the Romanian novel in the XIXth century.</p>
EEG Data for: "Composing only by thought: novel application of the P300 brain-computer interface"
<p>EEG Data for: "Composing only by thought: novel application of the P300 brain-computer interface". See the file "Information about the Dataset.pdf" for further information.</p>
A Novel Approach To Surface Operations With Multirotor UAVs
<p><strong>This video shows the indoor experimental evaluation of our latest aerial manipulation system which is capable of brushing surfaces. This is enabled by means of two innovations. The first innovation is a special tool that ‘drives’ over the surface using the friction generated by the interaction forces, while simultaneously applying a tool (here a brush) with a constant force on the surface using a spring. The second innovation is in the control theory, which stabilizes the UAV while allowing this movement. </strong></p> <p><strong>The experiment in the video shows how these innovations are applied to clean a patch on a surface, and is the validation step of the system before working on moving it outdoors towards the realistic scenario.</strong></p>
Assessing Pairwise Ecological Association Inference using a novel Ecological Network Inference Simulation-Validation Framework - Data Repository
<p>Accompanying data for manuscript entitled "<span>A novel Network Inference Simulation-Validation Framework for Assessment of Ecological Network Inference Performance</span>" whose submission is imminent.</p>
Psoriatic arthritis disease subtypes are phenocopied in a novel humanized murine model of psoriasis and joint inflammation
<p><em><span>Data processing and analysis</span></em></p> <p><span>Data normalization, quality control, and analysis was conducted by the UPMC Hillman Cancer Bioinformatics Services. Following the GeoMX NGS pipeline (<span>sequencing saturation 92%±0.12% (mean±S.E.M)), t</span>he resulting read count matrix was passed through robust QC procedure to remove ROIs of low surface area (<5000 µm<sup>2</sup>) or low perfect aligned reads (<80%), and probes of low quality or identified as global or local outliers (fails Grubbs outlier test in ≥ 20% segments). The remaining data were back-ground subtracted and Q3 normalized to house-keeping genes. ROIs were considered positive for CD8 T cells if their CD8 memory T cell deconvolution fraction was > 0 (R, spatialDecon, CellProfileLibrary; Human Adult ImmuneTumor_safeTME profile). Genes differentially expressed between groups of interest were detected using gene-wise linear modeling in R (edgeR, limma v3.50.3), with p-value adjusted for false discovery rate. Contrasts of groups were performed using t-tests at a significance level of 0.05.</span></p>
Graphical abstract in Novel Media for Lipid Production of Chlorococcum oleofaciens: A RSM Approach
Graphical abstract
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.