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906
datasets available to search
ShareScore release 0.9.0
Dataset results
906 results for “atherosclerosis”
Lipa regulates myeloid differentiation and is essential for intra-plaque macrophage accumulation during atherosclerosis
GEO Series GSE273731. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
An Antagonist of Toll-like Receptor 7 and 9 lowers cholesterol and reduces atherosclerosis in hyperlipidemic mice
GEO Series GSE28125. Mus musculus. 20 samples. Type: Expression profiling by array.
Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis [RNA-seq]
GEO Series GSE284071. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Lack of apoA-I in apoEKO mice causes skin xanthomas, worsening of inflammation and increased coronary atherosclerosis in the absence of hyperlipidemia
GEO Series GSE202237. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Short-term caloric restriction promotes resolution, while weight regain accelerates atherosclerosis in mice
GEO Series GSE225077. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article-Fenretinide treatment accelerates atherosclerosis development in apoE‐deficient mice in spite of beneficial metabolic effects
<p>This record contains raw data related to the article "Fenretinide treatment accelerates atherosclerosis development in apoE‐deficient mice in spite of beneficial metabolic effects"</p> <p>Abstract</p> <p>Background and Purpose</p> <p>Fenretinide, a synthetic retinoid derivative first investigated for cancer prevention and treatment, has been shown to ameliorate glucose tolerance, improve plasma lipid profile and reduce body fat mass. These effects, together with its ability to inhibit ceramide synthesis, suggest that fenretinide may have an anti‐atherosclerotic action.</p> <p>Experimental Approach</p> <p>To this aim, nine‐week‐old apoE‐knockout (EKO) female mice were fed for twelve weeks a Western diet, without (control) or with (0.1% <em>w</em>/w) fenretinide. As a reference, wild‐type (WT) mice were treated similarly. Growth and metabolic parameters were monitored throughout the study. Atherosclerosis development was evaluated in the aorta and at the aortic sinus. Blood and lymphoid organs were further characterized with thorough cytological/histological and immunocytofluorimetric analyses.</p> <p>Key Results</p> <p>Fenretinide treatment significantly lowered body weight, glucose levels and plasma levels of total cholesterol, triglycerides, and phospholipids. In the liver, fenretinide remarkably reduced hepatic glycogenosis and steatosis driven by the Western diet. Treated spleens were abnormally enlarged, with severe follicular atrophy and massive extramedullary haematopoiesis. Severe renal hemosiderin deposition was observed in treated EKO mice. Treatment resulted in a threefold increase of total leukocytes (WT and EKO) and raised the activated/resting monocyte ratio in EKO mice. Finally, atherosclerosis development was markedly increased at the aortic arch, thoracic and abdominal aorta of fenretinide‐treated mice.</p> <p>Conclusions and Implications</p> <p>We provide the first evidence that, despite beneficial metabolic effects, fenretinide treatment may enhance the development of atherosclerosis.</p>
Validation dataset and reference code for Carotid Vessel Wall Segmentation and Atherosclerosis Diagnosis Challenge, MICCAI 2022.
<p>Validation dataset and reference code for <strong>Carotid Vessel Wall Segmentation and Atherosclerosis Diagnosis Challenge, MICCAI 2022</strong>. </p> <p>Please refer to our website: <strong>https://vessel-wall-segmentation-2022.grand-challenge.org/</strong>.</p>
Link to dataset related to article "The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway "
<p>Link to dataset related to article "The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway"</p> <p>Abstract</p> <p><strong>Aims: </strong> Histone H3 dimethylation at lysine 79 is a key epigenetic mark uniquely induced by methyltransferase disruptor of telomeric silencing 1-like (DOT1L). We aimed to determine whether DOT1L modulates vascular smooth muscle cell (VSMC) phenotype and how it might affect atherosclerosis in vitro and in vivo, unravelling the related mechanism.</p> <p><strong>Methods and results: </strong> Gene expression screening of VSMCs stimulated with the BB isoform of platelet-derived growth factor led us to identify Dot1l as an early up-regulated epigenetic factor. Mouse and human atherosclerotic lesions were assessed for Dot1l expression, which resulted specifically localized in the VSMC compartment. The relevance of Dot1l to atherosclerosis pathogenesis was assessed through deletion of its gene in the VSMCs via an inducible, tissue-specific knock-out mouse model crossed with the ApoE-/- high-fat diet model of atherosclerosis. We found that the inactivation of Dot1l significantly reduced the progression of the disease. By combining RNA- and H3K79me2-chromatin immunoprecipitation-sequencing, we found that DOT1L and its induced H3K79me2 mark directly regulate the transcription of Nf-κB-1 and -2, master modulators of inflammation, which in turn induce the expression of CCL5 and CXCL10, cytokines fundamentally involved in atherosclerosis development. Finally, a correlation between coronary artery disease and genetic variations in the DOT1L gene was found because specific polymorphisms are associated with increased mRNA expression.</p> <p><strong>Conclusion: </strong> DOT1L plays a key role in the epigenetic control of VSMC gene expression, leading to atherosclerosis development. Results identify DOT1L as a potential therapeutic target for vascular diseases.</p>
The Effect of MK 0633 in Patients With Atherosclerosis (0633-008)(COMPLETED)
ClinicalTrials.gov study NCT00421278. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Androgens and Subclinical Atherosclerosis in Young Women - Ancillary to CARDIA
ClinicalTrials.gov study NCT00037245. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Prevalence & Progression of Subclinical Atherosclerosis
ClinicalTrials.gov study NCT00006503. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Estrogen Receptor Variants, HDL, and Atherosclerosis
ClinicalTrials.gov study NCT00081705. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Interleukin-4 (IL-4) as a Marker of Atherosclerosis
ClinicalTrials.gov study NCT00256035. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Contribution of Hepatic and Intestinal Lipoproteins to Human Atherosclerosis
ClinicalTrials.gov study NCT01321476. IPD Sharing: Not stated. Countries: 0. Publications: 0.
CEBPB drives endothelial pathological phenotype and promotes atherosclerosis by directly upregulating TGFBR1 expression [RNA-seq]
GEO Series GSE278347. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Lack of tolerogenic CD11c+ cells drives early atherosclerosis [RNA-seq]
GEO Series GSE275805. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
S-adenosylhomocysteine hydrolase deficiency exacerbates clonal 1 hematopoiesis and atherosclerosis via epigenetic regulation of inflammation
GEO Series GSE316282. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Hyperoxia impairs iPSC derived endothelial cells and drives an atherosclerosis-like transcriptional phenotype
GEO Series GSE263090. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Novel mirnas participate in Atherosclerosis through inflammation and apoptosis pathways (Mouse mRNA)
GEO Series GSE137581. Mus musculus. 6 samples. Type: Expression profiling by array.
Macrophage-derived KIF13B acts as a potential therapeutic target in atherosclerosis by enhancing MERTK-mediated efferocytosis [scRNA-Seq]
GEO Series GSE298574. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.