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2,168
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Dataset results
2,168 results for “deletion”
Endothelial deletion of EPH receptor A4 alters single-cell profile and Tie2/Akap12 signaling to preserve blood-brain barrier integrity
GEO Series GSE240430. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis of Mst1/2 deleted bronchiolar epithelial cells from adult mouse lungs
GEO Series GSE61627. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of wild type, sbp1 and scd6 deletion Saccharomyces cerevisiae strains upon RNA granule inducing sodium azide stress
GEO Series GSE145162. Saccharomyces cerevisiae. 12 samples. Type: Expression profiling by high throughput sequencing.
A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages
GEO Series GSE213020. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
INTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA
GEO Series GSE35383. Homo sapiens. 148 samples. Type: Genome variation profiling by array; Expression profiling by array; SNP genotyping by SNP array; Genome variation profiling by SNP array.
Effects of Conditional Egfr deletion on transcriptome of the mouse cerebral cortex
GEO Series GSE205624. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Analysis of gene expression in p53-null cell types following deletion of Mdm2
GEO Series GSE98705. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Global transcriptional profile of Salmonella enterica serovar Cerro 87 wild-type and its dpt genes deletion mutants at different growth state
GEO Series GSE59225. Salmonella enterica; Salmonella enterica subsp. enterica serovar Cerro. 24 samples. Type: Expression profiling by array.
Impact of NLUCAT1 deletion on A549 cells in normoxic and hypoxic conditions
GEO Series GSE117036. Homo sapiens. 12 samples. Type: Expression profiling by array.
Effects of Conditional Egfr deletion on transcriptome of the mouse cerebral cortex
GEO Series GSE214424. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Expression profiling pooled Drosophila melanogaster heterozygous for deletions on Chromosome 2L
GEO Series GSE61509. Drosophila melanogaster. 396 samples. Type: Expression profiling by high throughput sequencing.
Deletion mutant analysis of established glucose signaling and metabolic pathway members in Saccharomyces cerevisiae
GEO Series GSE33097. Saccharomyces cerevisiae. 295 samples. Type: Expression profiling by array.
Effect of deleting PexRAP/ADHAPR in adipose tissue of chow-fed male C57/BL6J mice
GEO Series GSE227912. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analyses of gene expression in Helicobacter pylori CrdRS two-component system deletion strains
GEO Series GSE221309. Helicobacter pylori 26695. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomics analysis of neurogenesis by striatal astrocytes upon Rbpj-K deletion
GEO Series GSE153916. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Comparison of Gametocyte producer 3D7-A subclone E5 to the gametotcyte nonprodcer strain F12 and pfap2-g deletion mutant
GEO Series GSE52030. Plasmodium falciparum. 32 samples. Type: Expression profiling by array.
Data from: Hepatocyte-specific deletion of TIPARP, a negative regulator of the aryl hydrocarbon receptor, is sufficient to increase sensitivity to dioxin-induced wasting syndrome
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD), which include thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents. Although the mechanisms of dioxin toxicity remain unknown, AHR signaling in hepatocytes is necessary for dioxin-induced liver toxicity. We previously reported that loss of TCDD-inducible poly(ADP-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. To test the hypothesis that TIPARP is a negative regulator of AHR signaling in hepatocytes, we generated Tiparpfl/fl mice in which exon 3 of Tiparp is flanked by loxP sites, followed by Cre-lox technology to create hepatocyte-specific (Tiparpfl/flCreAlb) and whole-body (Tiparpfl/flCreCMV; TiparpEx3-/-) Tiparp null mice. Tiparpfl/flCreAlb and TiparpEx3-/- mice given a single injection of 10 g/kg dioxin did not survive beyond day 7 and 9, respectively, while all Tiparp+/+ mice survived the 30-day treatment. Dioxin-exposed Tiparpfl/flCreAlb and TiparpEx3-/- mice had increased steatohepatitis and hepatotoxicity as indicated by greater staining of neutral lipids and serum alanine aminotransferase activity than similarly treated wild-type mice. Tiparpfl/flCreAlb and TiparpEx3-/- mice exhibited augmented AHR signalling, denoted by increased dioxin-induced gene expression. Metabolomic studies revealed alterations in lipid and amino acid metabolism in liver extracts from Tiparpfl/flCreAlb mice compared with wild-type mice. Taken together, these data illustrate that TIPARP is an important negative regulator of AHR activity, and that its specific loss in hepatocytes is sufficient to increase sensitivity to dioxin-induced steatohepatitis and lethality.
Fig12--Photonic and Optomechanical Thermometry (TO BE DELETED)
<p>Data of figure 12 depicting the optical bistability spectra as a function of input optical power as well as temperature increase due to light absorption.</p> <p>The folder contains the raw optical bistable spectra for each input power and the analyzis python script.</p>
Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions
<p>Supplementary Figure S4. SNP alignment of multiple high-quality genomes from Cameroon, available genomes of lineage B.1.620 as well as earliest and latest genomes of lineages B.1.1.7, B.1.351, P.1, B.1.526.2, B.1.177.60, B.1.177.57, and B.1.1.280. Only polymorphic SNPs within the alignment that are shared by at least eight B.1.620 are shown and lineage B.1.620 is outlined with a dashed line. Sites identical to the reference (GenBank accession NC_045512) are shown in grey, changes from the reference are indicated and coloured by nucleotide (green for thymidine, red for adenosine, blue for cytosine, yellow for guanine, dark grey for ambiguities, black for gaps). The first 100 and the last 50 nucleotides are not included in the figure but were used to infer the phylogeny. If mutation results in an amino acid change, the column label indicates the gene, reference amino acid, amino acid site, and amino acid change in brackets. The maximum-likelihood phylogeny on the right shows the relationships between depicted genomes and was rooted on the reference sequence.</p>
Figure 1 from: Alvarado AT, Muñoz AM, Bartra MS, Valderrama-Wong M, González D, Quiñones LA, Varela N, Bendezú MR, García JA, Loja-Herrera B (2021) Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population. Pharmacia 68(4): 747-754. https://doi.org/10.3897/pharmacia.68.e71621
Figure 1 Mechanism of action of CYP1A1 and GSTM1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.