Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,032
datasets available to search
ShareScore release 0.9.0
Dataset results
2,032 results for “metastases”
Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer
GEO Series GSE38167. Homo sapiens. 67 samples. Type: Non-coding RNA profiling by array.
Mesenchymal-epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression
GEO Series GSE195655. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
GEO Series GSE242676. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases
GEO Series GSE62598. Mus musculus. 15 samples. Type: Expression profiling by array.
DNA-methylation profiling of melanoma metastases
GEO Series GSE203152. Homo sapiens. 41 samples. Type: Methylation profiling by genome tiling array.
Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model
GEO Series GSE43566. Mus musculus. 38 samples. Type: Expression profiling by array.
Single cell RNA analysis of breast cancer bone metastases
GEO Series GSE190772. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Single cell transcriptomes of brain metastases and micrometastases derived from triple negative human breast cancer cell line in mouse model.
GEO Series GSE152818. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Characterizing transcriptomic differences between between primary colorectal adenocarcinomas and distant metastases reveals subtypes of metastatic colorectal cancer
GEO Series GSE131418. Homo sapiens. 1135 samples. Type: Expression profiling by array.
Gene expression analyses of primary tumors and metastases, using p53 mouse models
GEO Series GSE43281. Mus musculus. 27 samples. Type: Expression profiling by array.
Immunosuppressive microenvironment restrains chemotherapy efficacy in liver metastases of triple-negative breast cancer
GEO Series GSE276098. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide gene expression profiling on pre-chemotherapy biopsies of osteosarcoma patients who developed metastases within 5yrs (n=34) and patients who did not develop metastases within 5yrs (n=19)
GEO Series GSE21257. Homo sapiens. 53 samples. Type: Expression profiling by array.
Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking
GEO Series GSE109485. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Multiplex-NGS for identification of differentially expressed miRNAs between colon cancer patients with and without metachronous metastases
GEO Series GSE63119. Homo sapiens. 50 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Data from: Oral administration of Polymyxin B modulates the activity of Lipooligosaccharide E. coli B against lung metastases in murine tumor models
Introduction: Polymyxin B (PmB) belongs to the group of cyclic peptide antibiotics, which neutralize the activity of LPS by binding to lipid A. The aim of this study was to analyze the effect of PmB on the biological activity of lipooligosaccharide (LOS E. coli B,rough form of LPS) in vitro and in experimental metastasis models. Results: Cultures of murine macrophage J774A.1 cells and murine bone marrow-derived dendritic cells (BM-DC) stimulated in vitro with LOS and supplemented with PmB demonstrated a decrease in inflammatory cytokine production (IL-6, IL-10, TNF-α) and down-regulation of CD40, CD80, CD86 and MHC class II molecule expression. Additionally, PmB suspended in drinking water was given to the C57BL/6 mice seven or five days prior to the intravenous injection of B16 or LLC cells and intraperitoneal application of LOS. This strategy of PmB administration was continued throughout the duration of the experiments (29 or 21 days). In B16 model, statistically significant decrease in the number of metastases in mice treated with PmB and LOS (p<0.01) was found on the 14th day of the experiments, whereas the most intensive changes in surface-antigen expression and ex vivo production of IL-6, IL-1β and TNF-α by peritoneal cells were observed 7 days earlier. By contrast, antigen expression and ex vivo production of IL-6, IL-10, IFN-γ by splenocytes remained relatively high and stable. Statistically significant decrease in LLC metastases number was observed after the application of LOS (p<0.01) and in the group of mice preconditioned by PmB and subsequently treated with LOS (LOS + PmB, p<0.01). Conclusions: In conclusion, prolonged in vivo application of PmB was not able to neutralize the LOS-induced immune cell activity but its presence in the organism of treated mice was important in modulation of the LOS-mediated response against the development of metastases.
Stereotactic Radiation Therapy in Treating Patients With Brain Metastases
ClinicalTrials.gov study NCT00006259. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Imaging Agent (I-124 M5A) in Detecting CEA-Positive Liver Metastases in Patients With Colorectal Cancer
ClinicalTrials.gov study NCT03993327. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Brain Metastases Research Platform to Tackle the Challenge of CNS Metastases in Solid Tumours
ClinicalTrials.gov study NCT04109131. IPD Sharing: Not stated. Countries: 3. Publications: 0.
A Study of Oral IRAK-4 Inhibitor CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery in Patients With Melanoma Brain Metastases
ClinicalTrials.gov study NCT05669352. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of Advanced Castration Resistant Prostate Carcinoma With Limited Bone Metastases (α-RT)
ClinicalTrials.gov study NCT02484339. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.